细胞穿透肽
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- CAS号:
- 888486-23-5
- 英文名:
- H-Ala-Cys-Ser-Ser-Ser-Pro-Ser-Lys-His-Cys-Gly-OH, (Disulfide bond)
- 英文别名:
- TD 1 (peptide);Transdermal Peptide Disulfide;Transdermal Peptide (TD 1 peptide);H-Ala-Cys-Ser-Ser-Ser-Pro-Ser-Lys-His-Cys-Gly-OH, (Disulfide bond);Glycine, L-alanyl-L-cysteinyl-L-seryl-L-seryl-L-seryl-L-prolyl-L-seryl-L-lysyl-L-histidyl-L-cysteinyl-, cyclic (2→10)-disulfide (9CI)
- 中文名:
- 细胞穿透肽
- 中文别名:
- 透皮肽;细胞穿透肽 TRANSDERMAL PEPTIDE
- CBNumber:
- CB21513402
- 分子式:
- C40H64N14O16S2
- 分子量:
- 1061.15
- MOL File:
- 888486-23-5.mol
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细胞穿透肽化学性质
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沸点:
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1728.7±65.0 °C(Predicted)
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密度:
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1.54±0.1 g/cm3(Predicted)
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酸度系数(pKa):
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3.57±0.10(Predicted)
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序列:
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H-Ala-Cys-Ser-Ser-Ser-Pro-Ser-Lys-His-Cys-Gly-OH(Disulfide bond)
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细胞穿透肽性质、用途与生产工艺
Transdermal Peptide Disulfide (TD 1 Disulfide(peptide)) 是由 11 个氨基酸组成的多肽，可以与 Na+/K+-ATPase beta-subunit (ATP1B1) 结合，主要与 ATP1B1 的 C 末端相互作用。Transdermal Peptide Disulfide 能够增强一些大分子在皮肤中的传递。
In the presence of Transdermal Peptide Disulfide, because of the specific binding of Transdermal Peptide Disulfide to ATP1B1, cells will upregulate the level of ATP1B1 to maintain function and structure; as a result, the expression of ATP1B1 increases. However, as time goes on, some Transdermal Peptide Disulfide molecules may be transported into cells by endocytosis; consequently, the expression of ATP1B1 then decreases. The interaction between Transdermal Peptide Disulfide and ATP1B1 changes not only the expression of ATP1B1, but also the localization of ATP1B1 and then the structure of the epidermal layer. This interaction can be attenuated by inhibitors or competitors, which would result in the reduced delivery of macromolecular drugs across the skin.
多肽
细胞穿透肽是由 11 个氨基酸组成的多肽，可以通过细胞渗透压起到穿膜效果，细胞穿透肽能够增强一些大分子在皮肤中的传递。细胞穿透肽序列中有连续三个Ser，在多肽合成过程中，需要注意选择合适的反应条件，避免副反应的产生。
参考质量标准
外观:白色粉末
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
细胞穿透肽
上下游产品信息
上游原料
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888486-23-5, 细胞穿透肽 相关搜索:
- 目录肽
- 目录多肽
- 美容肽
- 多肽
- C40H64N14O16S2
- 透皮肽
- 细胞穿透肽 TRANSDERMAL PEPTIDE
- 888486-23-5
- Transdermal Peptide Disulfide
- Glycine, L-alanyl-L-cysteinyl-L-seryl-L-seryl-L-seryl-L-prolyl-L-seryl-L-lysyl-L-histidyl-L-cysteinyl-, cyclic (2→10)-disulfide (9CI)
- TD 1 (peptide)
- Transdermal Peptide (TD 1 peptide)
- H-Ala-Cys-Ser-Ser-Ser-Pro-Ser-Lys-His-Cys-Gly-OH, (Disulfide bond)