环二腺苷酸
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- CAS号:
- 54447-84-6
- 英文名:
- c-di-AMP
- 英文别名:
- di-AMP;di-cAMP;c-di-AMP;Cyclic-di-AMP;c di AMP,cdiAMP;Cyclic diadenylate;Adenosine Impurity 13;Cyclic di-3',5'-adenylate;c-di-AMP (Cyclic diadenylate;S-Adenosyl-L-Methionine Impurity 20
- 中文名:
- 环二腺苷酸
- 中文别名:
- 环二腺苷酸;腺苷杂质13;化合物 T10642;腺苷杂质 9(环二 AMP);S-腺苷基-L-蛋氨酸杂质20
- CBNumber:
- CB22715616
- 分子式:
- C20H24N10O12P2
- 分子量:
- 658.42
- MOL File:
- 54447-84-6.mol
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环二腺苷酸化学性质
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沸点:
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1096.7±75.0 °C(Predicted)
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密度:
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2.52±0.1 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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Soluble in DMSO
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形态:
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powder
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酸度系数(pKa):
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0.96±0.70(Predicted)
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颜色:
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white to beige
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环二腺苷酸性质、用途与生产工艺
c-di-AMP (Cyclic diadenylate) 是 STING 激动剂，其与 STING 结合，从而激活 TBK3-IRF3 信号传导途径，随后引发 I 型 IFN 和 TNF 产生。c-di-AMP (Cyclic diadenylate) 是一种细菌第二信使，主要在革兰氏阳性细菌中，可调节细胞生长，存活以及毒力。c-di-AMP (Cyclic diadenylate) 也调节宿主免疫反应。c-di-AMP (Cyclic diadenylate) 可作为一种有效的粘膜佐剂，刺激体液和细胞反应。
c-di-AMP (Cyclic diadenylate) signaling is a central factor in many Gram-positive bacteria regulating cell wall synthesis, potassium ion channels, DNA repair, and biofilm formation. c-di-AMP is also essential for cell growth, survival, and virulence of several well-known human pathogenic bacteria including
S. aureus
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L. monocytogenes
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S. pyogenes
, and
Mycobacterium spp
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c-di-AMP (Cyclic diadenylate) combines with model antigens, such as OVA or β-Gal, acts as a potent mucosal adjuvant stimulating both humoral and cellular responses.
环二腺苷酸
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2025/05/22 | HY-12326 | 环二腺苷酸
c-di-AMP | 54447-84-6 | 500 μg | 1200元 |
| 2025/05/22 | HY-12326 | 环二腺苷酸
c-di-AMP | 54447-84-6 | 1 mg | 1800元 |
54447-84-6, 环二腺苷酸 相关搜索:
- Nucleotide
- 杂质对照品
- 抑制剂
- 药靶配体
- DNA单体
- C20H24N10O12P2
- S-腺苷基-L-蛋氨酸杂质20
- 腺苷杂质 9(环二 AMP)
- 化合物 T10642
- 腺苷杂质13
- 环二腺苷酸
- 54447-84-6
- Cyclic di-adenosine monophosphate sodium salt
- Adenosine Impurity 9 (Cyclic-di-AMP)
- S-Adenosyl-L-Methionine Impurity 20
- (1S,6R,8R,9R,10S,15R,17R,18R)-8,17-bis(6-amino-9H-purin-9-yl)-3,9,12,18-tetrahydroxy-2,4,7,11,13,16-hexaoxa-3λ?,12λ?-diphosphatricyclo[13.3.0.0?,1?]octadecane-3,12-dione
- c di AMP,cdiAMP
- Adenosine Impurity 13
- c-Di-AMP(Cyclic-Di-AMP) ammonium salt
- 3'-Adenylic acid, adenylyl-(3'→5')-, cyclic nucleotide
- c-di-AMP (Cyclic diadenylate
- Cyclic-di-AMP
- Cyclic diadenylate
- Cyclic di-3',5'-adenylate
- di-cAMP
- di-AMP
- c-di-AMP