MRTX-1719
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- CAS号:
- 2630904-45-7
- 英文名:
- MRTX-1719
- 英文别名:
- BMS 986504;Navlimetostat;MRTX1719 ，E1024;navlimetostatum;MRTX-1719, 10 mM in DMSO;MRTX-1719,CRC,Histone Methyltransferase,NSCLC,Inhibitor,MTA,MRTX1719,MRTX 1719,inhibit,PRMT5;2-[4-[4-(Aminomethyl)-1-oxo-1,2-dihydrophthalazin-6-yl]-1-methyl-5-pyrazolyl]-4-chloro-6-cyclopropoxy-3-fluorobenzonitrile;(2R)-2-(4-(4-(Aminomethyl)-1-oxo-1,2-dihydrophthalazin-6-yl)-1-methyl-1H-pyrazol-5-yl)-4-chloro-6-cyclopropoxy-3-fluorobenzonitrile;Benzonitrile, 2-[4-[4-(aminomethyl)-1,2-dihydro-1-oxo-6-phthalazinyl]-1-methyl-1H-pyrazol-5-yl]-4-chloro-6-(cyclopropyloxy)-3-fluoro-, (2R)-;Benzonitrile, 2-[4-[4-(aminomethyl)-1,2-dihydro-1-oxo-6-phthalazinyl]-1-methyl-1H-pyrazol-5-yl]-4-chloro-6-(cyclopropyloxy)-3-fluoro-, (2R)- - [AC78275]
- 中文名:
- MRTX-1719
- 中文别名:
- 化合物MRTX-1719;MRTX1719 ,E1024;化合物MRTX-1719,10 MM DMSO 溶液;2-[4-[4-(氨甲基)-1-氧代-1,2-二氢酞嗪-6-基]-1-甲基-5-吡唑基]-4-氯-6-环丙氧基-3-氟苯甲腈;(2R)-2-(4-(4-(氨基甲基)-1-氧代-1,2-二氢酞嗪-6-基)-1-甲基-1H-吡唑-5-基)-4-氯-6-环丙氧基-3-氟苯甲腈
- CBNumber:
- CB29782000
- 分子式:
- C23H18ClFN6O2
- 分子量:
- 464.89
- MOL File:
- 2630904-45-7.mol
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MRTX-1719化学性质
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密度:
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1.58±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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酸度系数(pKa):
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11.37±0.40(Predicted)
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形态:
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Solid
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颜色:
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White to light yellow
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InChIKey:
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BZKIOORWZAXIBA-UHFFFAOYSA-N
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SMILES:
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CN1N=CC(C2=CC=C3C(NN=C(CN)C3=C2)=O)=C1C1C(=C(Cl)C=C(OC2CC2)C=1C#N)F
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MRTX-1719性质、用途与生产工艺
MRTX-1719 是一种有效的，具有口服活性，选择性的 PRMT5•MTA 复合物抑制剂，对PRMT5•MTA 和 PRMT5 的 IC50 分别为 3.6 和 20.5 nM。MRTX-1719 可以与 PRMT5•MTA 复合物结合，KD 值为 0.14 pM。MRTX-1719 在体内外显示出抗肿瘤活性，可用于癌症研究。
MRTX-1719
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2025/05/22 | HY-139611 | MRTX-1719
Navlimetostat | | 1 mg | 2590元 |
| 2025/05/22 | HY-139611 | MRTX-1719
Navlimetostat | | 5 mg | 5050元 |
2630904-45-7, MRTX-1719 相关搜索:
- 化学试剂
- 抑制剂
- C23H18ClFN6O2
- MRTX1719 ,E1024
- 化合物MRTX-1719,10 MM DMSO 溶液
- (2R)-2-(4-(4-(氨基甲基)-1-氧代-1,2-二氢酞嗪-6-基)-1-甲基-1H-吡唑-5-基)-4-氯-6-环丙氧基-3-氟苯甲腈
- 2-[4-[4-(氨甲基)-1-氧代-1,2-二氢酞嗪-6-基]-1-甲基-5-吡唑基]-4-氯-6-环丙氧基-3-氟苯甲腈
- 化合物MRTX-1719
- 2630904-45-7
- Benzonitrile, 2-[4-[4-(aminomethyl)-1,2-dihydro-1-oxo-6-phthalazinyl]-1-methyl-1H-pyrazol-5-yl]-4-chloro-6-(cyclopropyloxy)-3-fluoro-, (2R)- - [AC78275]
- MRTX1719 ，E1024
- navlimetostatum
- BMS 986504
- Navlimetostat
- MRTX-1719, 10 mM in DMSO
- (2R)-2-(4-(4-(Aminomethyl)-1-oxo-1,2-dihydrophthalazin-6-yl)-1-methyl-1H-pyrazol-5-yl)-4-chloro-6-cyclopropoxy-3-fluorobenzonitrile
- 2-[4-[4-(Aminomethyl)-1-oxo-1,2-dihydrophthalazin-6-yl]-1-methyl-5-pyrazolyl]-4-chloro-6-cyclopropoxy-3-fluorobenzonitrile
- MRTX-1719,CRC,Histone Methyltransferase,NSCLC,Inhibitor,MTA,MRTX1719,MRTX 1719,inhibit,PRMT5
- Benzonitrile, 2-[4-[4-(aminomethyl)-1,2-dihydro-1-oxo-6-phthalazinyl]-1-methyl-1H-pyrazol-5-yl]-4-chloro-6-(cyclopropyloxy)-3-fluoro-, (2R)-