化合物 2-FUROYL-LIGRLO-AMIDE TFA
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- CAS号:
- 2468029-34-5
- 英文名:
- 2-Furoyl-LIGRLO-amide TFA
- 英文别名:
- 2-Furoyl-LIGRLO-amide TFA
- 中文名:
- 化合物 2-FUROYL-LIGRLO-AMIDE TFA
- 中文别名:
- CBNumber:
- CB35540609
- 分子式:
- C36H63N11O8.C2HF3O2
- 分子量:
- 891.98
- MOL File:
- 2468029-34-5.mol
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化合物 2-FUROYL-LIGRLO-AMIDE TFA化学性质
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序列:
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{Fur-2-oyl}-Leu-Ile-Gly-Arg-Leu-{Orn}-NH2
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化合物 2-FUROYL-LIGRLO-AMIDE TFA性质、用途与生产工艺
2-Furoyl-LIGRLO-amide TFA 是一种有效的选择性蛋白酶激活受体2 (PAR2) 激动剂， 其 pD2 值为 7.0。
Proteinase-activated receptor 2 (PAR2)
2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH
2
) is equally effective to and 10 to 25 times more potent than SLIGRLNH
2
for increasing intracellular calcium in cultured human and rat PAR2-expressing cells, respectively.
In bioassays of tissue PAR2 activity, measured as arterial vasodilation and hyperpolarization, 2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH
2
) is 10 to 300 times more potent than SLIGRL-NH
2
. Unlike trans-cinnamoyl-LIGRLO-NH
2
, 2-Furoyl-LIGRLO-amide do not cause a prominent non-PAR2-mediated contraction of murine femoral arteries.
Furoyl-LIGRLO-amide TFA (injected intradermally at the nape of the neck; 10 μg; pre-injected) exhibits fewer scratches in response to 2-Furoyl-LIGRLO-amide but not to histamine in Trpv3
-/-
mice. But it decreases significantly the number of scratches in WT mice.
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Animal Model:
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Adult male (2/3-month-old) Trpv3
-/-
and WT mice
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Dosage:
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10 μg
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Administration:
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Injected intradermally at the nape of the neck
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Result:
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Was involved in PAR2- induced acute itch.
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化合物 2-FUROYL-LIGRLO-AMIDE TFA
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2023/03/20 | HY-P1314A | 2-Furoyl-LIGRLO-amide TFA | | 1mg | 1200元 |
| 2023/03/20 | HY-P1314A | 2-Furoyl-LIGRLO-amide TFA | | 5mg | 3600元 |
化合物 2-FUROYL-LIGRLO-AMIDE TFA
生产厂家
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