2-(1,4-二氧杂螺[4.5]癸-8-基亚甲基)乙酸乙酯
|
|
|
- CAS号:
- 51656-91-8
- 英文名:
- ethyl 2-(1,4-dioxaspiro[4.5]decan-8-ylidene)acetate
- 英文别名:
- NSC 649463;Aceticacid, 1,4-dioxaspiro[4.5;Ethyl 1,4-dioxaspiro[4.5]dec-8-ylideneacetate;ethyl 2-(1,4-dioxaspiro[4.5]decan-8-ylidene)acetate;ethyl 2-(1,4-dioxaspiro[4.5]decan-8-ylidene)acetate-24;8-[(Ethoxycarbonyl)methylidene]-1,4-dioxaspiro[4.5]decane;4-(4-oxo-1-cyclohexa-2,5-dienylidene)-1-cyclohexa-2,5-dienone;2-(1,4-Dioxaspiro[4.5]decan-8-ylidene)acetic acid ethyl ester;Acetic acid, 2-(1,4-dioxaspiro[4.5]dec-8-ylidene)-, ethyl ester
- 中文名:
- 2-(1,4-二氧杂螺[4.5]癸-8-基亚甲基)乙酸乙酯
- 中文别名:
- 1,4-二氧杂-螺环[4,5]癸烷-8-亚乙酸乙酯;2-(1,4-二氧杂螺[4.5]癸-8-亚基)乙酸乙酯;2-(1,4-二氧杂螺[4.5]癸烷-8-亚基)乙酸乙酯;2-(1,4-二氧阿司匹林[4.5]癸-8-亚基)乙酸乙酯;2-(1,4-二氧杂螺[4.5]癸-8-基亚甲基)乙酸乙酯
- CBNumber:
- CB42619336
- 分子式:
- C12H18O4
- 分子量:
- 226.27
- MOL File:
- 51656-91-8.mol
|
|
|
2-(1,4-二氧杂螺[4.5]癸-8-基亚甲基)乙酸乙酯化学性质
-
沸点:
-
327.8±42.0 °C(Predicted)
-
|
-
密度:
-
1.13±0.1 g/cm3(Predicted)
-
|
-
储存条件:
-
under inert gas (nitrogen or Argon) at 2-8°C
-
|
2-(1,4-二氧杂螺[4.5]癸-8-基亚甲基)乙酸乙酯性质、用途与生产工艺
生产方法
以1,4-环己二酮单乙二醇缩酮为原料合成2-(1,4-二氧杂螺[4.5]癸-8-亚基)乙酸乙酯的一般步骤如下：在0℃条件下，将膦酸三乙酯（44.8g，200mmol）溶解于THF（30ml）中，随后加入1M的双（三甲基甲硅烷基氨基）钠THF溶液（200ml）。将反应混合物在室温下搅拌0.5小时后，再次冷却至0℃。缓慢滴加1,4-环己二酮单乙二醇缩酮（15.6g，200mmol）的THF（50ml）溶液。滴加完毕后，将反应液在室温下继续搅拌18小时。反应完成后，将混合物冷却至0℃，用冷的柠檬酸水溶液淬灭反应，随后用EtOAc进行萃取。有机相依次用饱和NaHCO3水溶液、盐水洗涤，并用Na2SO4干燥。干燥后的有机相经过滤、浓缩，得到的粗产物通过硅胶柱色谱纯化，采用CH2Cl2/EtOAc梯度洗脱，最终得到目标产物2-(1,4-二氧杂螺[4.5]癸-8-亚基)乙酸乙酯（21g，收率91%）。
参考文献：
[1] Patent: US2006/264489, 2006, A1. Location in patent: Page/Page column 77-78
[2] Patent: US5877199, 1999, A
[3] Patent: WO2006/115168, 2006, A1. Location in patent: Page/Page column 106-107
[4] Patent: WO2007/73934, 2007, A1. Location in patent: Page/Page column 92-93
[5] Patent: WO2004/99191, 2004, A2. Location in patent: Page 17
2-(1,4-二氧杂螺[4.5]癸-8-基亚甲基)乙酸乙酯
上下游产品信息
上游原料
下游产品
2-(1,4-二氧杂螺[4.5]癸-8-基亚甲基)乙酸乙酯
生产厂家
51656-91-8, 2-(1,4-二氧杂螺[4.5]癸-8-基亚甲基)乙酸乙酯 相关搜索:
- 2-(1,4-二氧阿司匹林[4.5]癸-8-亚基)乙酸乙酯
- 2-(1,4-二氧杂螺[4.5]癸-8-亚基)乙酸乙酯
- 2-(1,4-二氧杂螺[4.5]癸-8-基亚甲基)乙酸乙酯
- 1,4-二氧杂-螺环[4,5]癸烷-8-亚乙酸乙酯
- 2-(1,4-二氧杂螺[4.5]癸烷-8-亚基)乙酸乙酯
- 51656-91-8
- Aceticacid, 1,4-dioxaspiro[4.5
- Acetic acid, 2-(1,4-dioxaspiro[4.5]dec-8-ylidene)-, ethyl ester
- 2-(1,4-Dioxaspiro[4.5]decan-8-ylidene)acetic acid ethyl ester
- NSC 649463
- 8-[(Ethoxycarbonyl)methylidene]-1,4-dioxaspiro[4.5]decane
- 4-(4-oxo-1-cyclohexa-2,5-dienylidene)-1-cyclohexa-2,5-dienone
- Ethyl 1,4-dioxaspiro[4.5]dec-8-ylideneacetate
- ethyl 2-(1,4-dioxaspiro[4.5]decan-8-ylidene)acetate-24
- ethyl 2-(1,4-dioxaspiro[4.5]decan-8-ylidene)acetate