SB 203580盐酸盐
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- CAS号:
- 869185-85-3
- 英文名:
- SB 203580 (hydrochloride)
- 英文别名:
- SB203580 HCl;RWJ 64809 HCl;RWJ 64809 hydrochloride;Adezmapimod (hydrochloride);Adezmapimod (SB-203580) hydrochloride;SB 203580 hydrochloride, p38 MAPK inhibitor;SB 203580 hydrochloride (RWJ 64809 hydrochloride;SB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem;RWJ 64809 HYDROCHLORIDE;SB203580 HYDROCHLORIDE;SB-203580 HYDROCHLORIDE
- 中文名:
- SB 203580盐酸盐
- 中文别名:
- 化合物 T21675;SB 203580盐酸盐;化合物 SB 203580 HYDROCHLORIDE;SB 203580 HYDROCHLORIDE,P38 MAPK抑制剂;4-(4-(4-氟苯基)-2-(4-(甲基亚磺酰基)苯基)-1H-咪唑-5-基)吡啶盐酸盐;SB 203580 hydrochloride (RWJ 64809 hydrochloride;SB203580 hydrochloride;SB-203580 hydrochloride)
- CBNumber:
- CB52592405
- 分子式:
- C21H17ClFN3OS
- 分子量:
- 413.9
- MOL File:
- 869185-85-3.mol
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SB 203580盐酸盐化学性质
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储存条件:
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-20C
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溶解度:
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insoluble in EtOH; insoluble in H2O; ≥20.7 mg/mL in DMSO
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形态:
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Bright yellow solid
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颜色:
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Light yellow to yellow
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水溶解性:
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Soluble to 25 mM in water
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稳定性:
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Hygroscopic
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InChI:
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1S/C21H16FN3OS.ClH/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15;/h2-13H,1H3,(H,24,25);1H
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InChIKey:
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WOSGGXINSLMASH-UHFFFAOYSA-N
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SMILES:
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Fc1ccc(cc1)c2[nH]c(nc2c4ccncc4)c3ccc(cc3)[S](=O)C.Cl
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SB 203580盐酸盐性质、用途与生产工艺
SB 203580 hydrochloride (RWJ 64809 hydrochloride) 是一种选择性的，ATP 竞争性的 p38 MAPK 抑制剂，对 SAPK2a/p38 和 SAPK2b/p38β2 的 IC50 分别为 50 nM 和 500 nM。SB 203580 hydrochloride 抑制 LCK，GSK3β 和 PKBα，IC50 比 SAPK2a/p38 高 100-500 倍。SB 203580 hydrochloride 是一种自噬 (autophagy) 和有丝分裂 (mitophagy) 激活剂。
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p38
50 nM (IC
50
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p38β2
500 nM (IC
50
)
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SB 203580 (preincubated with 0-30 μM for 1 h and cultured for 24 h in the presence of 20 ng/mL IL-2) prevents the IL-2-induced proliferation of primary human T cells, murine CT6 T cells, or BAF F7 B cells with an IC
50
of 3-5 μM.
SB203580 blocks PKB phosphorylation (IC
50
3-5 μM). SB203580 inhibitsthe phosphorylation of Ser473 in a dose-dependent manner in both CT6 and activated human T cells and IL-2-responsive BA/F3 F7 B cells.
Cell Proliferation Assay
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Cell Line:
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CT6, BA/F3 cell line F7, and PBMC/T cells
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Concentration:
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0-30 μM
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Incubation Time:
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Preincubated with 0-30 μM SB203580 for 1 h and cultured for 24 h in the presence of 20 ng/mL IL-2
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Result:
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Prevented the IL-2-induced proliferation of primary human T cells, murine CT6 T cells, or BAF F7 B cells with an IC
50
of 3-5 μM.
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Western Blot Analysis
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Cell Line:
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CT6 cells, activated human T cells, and BA/F3 F7 cells
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Concentration:
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0-30 μM
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Incubation Time:
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Preincubated with 0-30 μM SB203580 for 1 h before stimulating with 20 ng/mL IL-2 for 5 min
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Result:
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Inhibited the phosphorylation of PKB at Ser473 in a dose-dependent manner.
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SB203580 (5 mg/kg/day; intra peritoneal injected daily for 16 consecutive days, in female atymic Nu/Nu mice) treatment, p38WT tumors show a significantly smaller tumor burden when compared with p38TM tumors that were treated in parallel.
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Animal Model:
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Six-week-old female atymic Nu/Nu mice CAL27 p38WT and p38TM tumors
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Dosage:
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5 mg/kg/day
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Administration:
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Intra peritoneal injected daily for 16 consecutive days
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Result:
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After 2 weeks treatment, CAL27 p38WT tumors were significantly smaller; CAL27 p38TM tumors were not affected by the p38 inhibitor (n=10).
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SB 203580盐酸盐
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2025/12/22 | HY-10256A | SB 203580盐酸盐
Adezmapimod hydrochloride | 869185-85-3 | 5 mg | 330元 |
| 2025/12/22 | HY-10256A | 869185-85-3
Adezmapimod hydrochloride | 869185-85-3 | 10mM * 1mLin DMSO | 363元 |
869185-85-3, SB 203580盐酸盐 相关搜索:
- 抑制剂
- 药靶配体
- C21H17ClFN3OS
- SB 203580 hydrochloride (RWJ 64809 hydrochloride;SB203580 hydrochloride;SB-203580 hydrochloride)
- SB 203580 HYDROCHLORIDE,P38 MAPK抑制剂
- 4-(4-(4-氟苯基)-2-(4-(甲基亚磺酰基)苯基)-1H-咪唑-5-基)吡啶盐酸盐
- 化合物 SB 203580 HYDROCHLORIDE
- SB 203580盐酸盐
- 化合物 T21675
- 869185-85-3
- SB 203580 hydrochloride (RWJ 64809 hydrochloride
- SB 203580 hydrochloride, p38 MAPK inhibitor
- SB203580 HCl
- RWJ 64809 HCl
- Adezmapimod (SB-203580) hydrochloride
- Adezmapimod (hydrochloride)
- SB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem
- RWJ 64809 HYDROCHLORIDE;SB203580 HYDROCHLORIDE;SB-203580 HYDROCHLORIDE
- RWJ 64809 hydrochloride