阿维菌素 B1a
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- CAS号:
- 65195-55-3
- 英文名:
- Avermectin B1a
- 英文别名:
- Abamectina;Avamectin B1a;AbaMectin B1a;C-076B1a;ABERMECTINS;Abamectinum;avermectin b1a;Antibiotic C-076B1a;Abamectine [french];Abamectinum [latin]
- 中文名:
- 阿维菌素 B1a
- 中文别名:
- 阿巴汀;齐螨素;克螨灵;爱弗菌素;阿维菌素原料药;伊维菌素杂质3;依维菌素杂质1;多拉菌素杂质3;阿维菌素 B1a;伊维菌素EP杂质A
- CBNumber:
- CB5854808
- 分子式:
- C48H72O14
- 分子量:
- 873.09
- MOL File:
- 65195-55-3.mol
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阿维菌素 B1a化学性质
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沸点:
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940.9±65.0 °C(Predicted)
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密度:
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1.24±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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≥143.4 mg/mL in DMSO; ≥11.86 mg/mL in EtOH with ultrasonic; insoluble in H2O
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形态:
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Powder
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酸度系数(pKa):
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12.42±0.70(Predicted)
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颜色:
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White to light yellow
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稳定性:
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Hygroscopic
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InChIKey:
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RRZXIRBKKLTSOM-CGBKEAFXNA-N
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EPA化学物质信息:
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Avermectin B1a (65195-55-3)
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阿维菌素 B1a性质、用途与生产工艺
阿维菌素 B1a是一种大环内酯二糖驱虫剂，可与哺乳动物 GABAA 受体上的高亲和力和低亲和力位点结合。与高亲和力位点结合可激活受体以增加氯离子流入，而与低亲和力位点结合则可阻断通道。阿维菌素 B1a 可抑制甘氨酸受体拮抗剂士的宁与大鼠脊髓膜和可溶性受体的结合（Kis 分别为 1.3 和 3.6 µM）。含有阿维菌素 B1a（>80%）和阿维菌素 B1b（~20%，Cay-17453）的配方可用作杀虫剂和兽医驱虫配方，如阿维菌素（Cay-19201）。
Avermectin B1a 是一种抗寄生虫剂，能够使线虫瘫痪。
[
3
H]AVM B1a preferentially binds to synaptic membranes from several regions of rat brain. [
3
H]AVM B1a specific binding to intact monolayers of granule cells increases rapidly with time of incubation and reaches equilibrium after approximately 20 min at 24°C. Higher concentrations of [
3
H]AVM B1a leads to markedly greater nonspecific binding, 60% at 25 nM. Various AVM analogs also produce concentration-dependent inhibition of [
3
H]AVM B1a binding in intact cerebellar neurons. AVM B1a and moxidectin are similar in potency (IC
50
values, 120 and 126 nM, respectively). AVMB1a-stimulated chloride efflux from mouse brain synaptic vesicles results from the activation of GABA-insensitive chloride channels and that this action is distinct from their previously documented effects on GABA-gated chloride channels in mouse brain preparations.
Bacteria are significantly inhibited when the AVM B1a concentration is higher than 83.3 mg/kg, while fungi are less impaired in soil. Soil respiration is also inhibited by high concentration AVM B1a, which differs with soil types. The half lethal dosage (LD
50
) of AVM B1a to soil earthworm is estimated as 4.63 mg × cm
2
in filter paper contact test, and as 24.13 and 17.06 mg/kg, respectively after treated 7 and 14 days in artificial soil. Iin artificial soil, the LC50 of AVM B1a on earthworms are 24.1 mg/kg and 17.1 mg/kg, respectively, for 7 and 14 days. About 80.0% and 94.8% of the accumulated AVM B1a are eliminated respectively in two groups within 1 day after they are exposed to AVM B1a-free soil, but a trace amount of AVM B1a is found for a relative long time in earthworms.
类别
有毒物品
毒性分级
高毒
急性毒性
口服-大鼠 LD20: 10 毫克/公斤; 口服-小鼠 LD50: 19 毫克/公斤
可燃性危险特性
可燃; 燃烧产生刺激烟雾
储运特性
通风低温干燥
灭火剂
干粉,泡沫,沙土,二氧化碳, 雾状水
阿维菌素 B1a
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2025/05/22 | HY-15308 | 阿维菌素 B1a
Avermectin B1a | 65195-55-3 | 5mg | 250元 |
| 2025/05/22 | HY-15308 | 阿维菌素 B1a
Avermectin B1a | 65195-55-3 | 10mM * 1mLin DMSO | 340元 |
65195-55-3, 阿维菌素 B1a 相关搜索:
- 有机中间体
- 兽用原料
- 抑制剂
- 杂质对照品
- 其它杂质
- 药靶配体
- 阿维菌素
- 标准品
- 原药中间体
- API原料药-兽药原料药
- 原料
- 中间体
- 有机化工
- 原料
- 农业原料
- 化工原料
- 微生物代谢物
- 兽用原药
- C47H72O14
- 伊维菌素EP杂质1
- 阿维菌素 B1a|Avermectin B1a
- 阿维菌素 B1a|Avermectin B1a
- 阿维菌素 B1A,10 MM DMSO 溶液
- 乙腈中阿维菌素B1A溶液标准物质
- 乙腈中阿维菌素B1A
- 甲醇中阿维菌素B1A溶液标准物质
- 甲醇中阿维菌素B1A
- 阿维菌素检测标准品
- 多拉菌素杂质3
- 多拉菌素杂质3 阿维菌素 B1A
- 伊维菌素杂质1(伊维菌素EP杂质A)
- 伊维菌素EP杂质A(阿维菌素B1A,阿维菌素B1A)
- 伊维菌素杂质2(伊维菌素EP杂质A)
- 伊维菌素杂质3
- 伊维菌素EP杂质A
- 依维菌素杂质1
- 阿维菌素 B1a
- 齐螨素
- 克螨灵
- 爱弗菌素
- 阿巴汀
- 阿维菌素原料药
- 65195-55-3
- Ivermectin Impurity A(EP)
- Avermectin B1a 100 μg/mL in Acetonitrile
- Abamectin B1a 1000 μg/mL in Acetonitrile
- Ivermectin EP Impurity1
- Ivermectin impurity A
- Avermectin B1a (>85%)
- Avermectin B1a, 10 mM in DMSO
- Ivermectin impurity 2
- Dolamectin Impurity 3
- Doramectin Impurity
- Avermectin B1a Impurity / Avermectin Impurity-A
- Avermectin B1a in Acetonitrile
- Avermectin B1a 100 μg/ml Acetonitrile
- vermectin B1a, EvoPure?
- Ivermectin EP Impurity A (Avermectin B1a) (Abamectin B1a)