Etalocib
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- CAS号:
- 161172-51-6
- 英文名:
- Etalocib
- 英文别名:
- VML 295;LY293111;Etalocib;Etalocib(LY293111);LY293111 Exclusive;Etalocib, 10 mM in DMSO;YFIZRWPXUYFCSN-UHFFFAOYSA-N;2-(3-(3-((5-Ethyl-4'-fluoro-2-hydroxy-[1,1'-biphenyl]-4-yl)oxy)propoxy)-2-propylphenoxy)benzoic acid;Benzoic acid, 2-[3-[3-[(5-ethyl-4'-fluoro-2-hydroxy[1,1'-biphenyl]-4-yl)oxy]propoxy]-2-propylphenoxy]-;antiinflammatory,LY 293111,VML-295,VML 295,inhibit,LY-293111,Etalocib,Pulmonary,Leukotriene Receptor,Apoptosis,Inhibitor,asthma,bronchiectasis
- 中文名:
- Etalocib
- 中文别名:
- 化合物ETALOCIB;化合物ETALOCIB,10 MM DMSO 溶液;LY293111,白三烯 (LTB4) 受体的拮抗剂;2-[2-丙基-3-[3-[2-乙基-4-(4-氟苯基)-5-羟基苯氧基]丙氧基]苯氧基]苯甲酸;2-(3-(3-((5-乙基-4'-氟-2-羟基-[1,1'-联苯]-4-基)氧基)丙氧基)-2-丙基苯氧基)苯甲酸
- CBNumber:
- CB61856046
- 分子式:
- C33H33FO6
- 分子量:
- 544.61
- MOL File:
- 161172-51-6.mol
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Etalocib化学性质
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熔点:
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68-70 °C(Solv: acetonitrile (75-05-8))
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沸点:
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656.8±55.0 °C(Predicted)
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密度:
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1?+-.0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO:98.5(Max Conc. mg/mL);173.85(Max Conc. mM)
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酸度系数(pKa):
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3.32±0.36(Predicted)
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形态:
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Solid
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颜色:
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White to off-white
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Etalocib性质、用途与生产工艺
Etalocib (LY293111) 是具有口服活性的白三烯 (LTB4) 受体的拮抗剂，抑制 [3H]LTB4 结合的Ki 值为 25 nM. Etalocib (LY293111) 抑制LTB4 诱导的钙动员的 lC50 值为 20 nM。Etalocib (LY293111) 可诱导凋亡。
Etalocib (LY293111) elicits a concentration-dependent inhibition of LTB
4
induced CD11b up-regulation.
Etalocib (LY293111) is an extremely potent and selective antagonist of human neutrophil function in vitro.
Etalocib (LY293111, 250 and 500 nM, 24-72 h) induces apoptosis and inhibits proliferation in human pancreatic cancer cells.
Cell Proliferation Assay
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Cell Line:
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MiaPaCa-2 and AsPC-1 human pancreatic cancer cells.
[3]
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Concentration:
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500 nM.
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Incubation Time:
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24, 48, and 72 h.
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Result:
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Caused both a concentration-dependent and time-dependent inhibition of thymidine incorporation in both MiaPaCa-2 and AsPC-1 human pancreatic cancer cells.
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Apoptosis Analysis
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Cell Line:
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MiaPaCa-2 and AsPC-1 human pancreatic cancer cells.
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Concentration:
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250 and 500 nM.
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Incubation Time:
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24 h.
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Result:
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Induced apoptosis in human pancreatic cancer cells.
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Etalocib (LY293111) produces a dose-related inhibition of acute leukotriene B
4
-induced airway obstruction when administered i.v. (ED
50
=14 µg/kg) or p.o. (ED
50
=0.4 mg/kg).
Etalocib (LY293111, 10 mg/kg) inhibits A23187-induced lung inflammatory changes at 1 h.
Etalocib (LY293111, 250 mg/kg/day, orally) inhibits growth of human pancreatic cancer xenografts in athymic mice.
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Animal Model:
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Guinea pigs.
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Dosage:
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1-10 mg/kg.
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Administration:
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Orally once.
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Result:
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A single 1 mg/kg oral dose inhibited excised lung gas volume increases by 76.7±7.1% (n=4, P<0.002) when given 8 h prior to leukotriene B
4
challenge, and 28.6±20.3% (n=4, NS) when given 24 h before challenge.
Had no effect (10 mg/kg) on pulmonary gas trapping at 1 h or 2 h after A23187 challenge. However, at 4 h, the pulmonary gas trapping response was significantly less than that of vehicle-treated controls and not different from sham values. The 10 mg/kg dose inhibited A23187-induced lung inflammatory changes at 1 h, but was without effect at 2 h or 4 h after challenge.
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Etalocib
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2025/05/22 | HY-13628 | Etalocib | 161172-51-6 | 1 mg | 923元 |
| 2025/05/22 | HY-13628 | Etalocib
Etalocib | 161172-51-6 | 5mg | 2038元 |
161172-51-6, Etalocib 相关搜索:
- 抑制剂
- 合成有机化合物配体
- C33H33FO6
- 化合物ETALOCIB,10 MM DMSO 溶液
- 2-[2-丙基-3-[3-[2-乙基-4-(4-氟苯基)-5-羟基苯氧基]丙氧基]苯氧基]苯甲酸
- LY293111,白三烯 (LTB4) 受体的拮抗剂
- 化合物ETALOCIB
- 2-(3-(3-((5-乙基-4'-氟-2-羟基-[1,1'-联苯]-4-基)氧基)丙氧基)-2-丙基苯氧基)苯甲酸
- 161172-51-6
- Etalocib, 10 mM in DMSO
- antiinflammatory,LY 293111,VML-295,VML 295,inhibit,LY-293111,Etalocib,Pulmonary,Leukotriene Receptor,Apoptosis,Inhibitor,asthma,bronchiectasis
- Etalocib(LY293111)
- 2-(3-(3-((5-Ethyl-4'-fluoro-2-hydroxy-[1,1'-biphenyl]-4-yl)oxy)propoxy)-2-propylphenoxy)benzoic acid
- Benzoic acid, 2-[3-[3-[(5-ethyl-4'-fluoro-2-hydroxy[1,1'-biphenyl]-4-yl)oxy]propoxy]-2-propylphenoxy]-
- LY293111 Exclusive
- YFIZRWPXUYFCSN-UHFFFAOYSA-N
- VML 295
- LY293111
- Etalocib