3-羟基四氢呋喃
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- CAS号:
- 453-20-3
- 英文名:
- 3-Hydroxytetrahydrofuran
- 英文别名:
- Tetrahydrofuran-3-ol;3-Furanol, tetrahydro-;3-hydroxyoxolane;tetrahydro-3-furano;Tetrahydro-3-furanol;-Hydroxytetrahydrofuran;3-HYDROXYTETRAHYDROFURAN;3-HYDROXYTETRAHYDRAFURAN;3-Hydroxytetrahydrofurane;3-Hydroxytetrahydrofuran>
- 中文名:
- 3-羟基四氢呋喃
- 中文别名:
- 噁戊环-3-醇;3-羟基四氢呋喃;3-羟基四氢呋喃 1G;3-羟基四氢呋喃标准品;好产品 3-羟基四氢呋喃;3-羟基四氢呋喃,98%;3-羟基四氢呋喃,四氢呋喃-3-醇
- CBNumber:
- CB6194228
- 分子式:
- C4H8O2
- 分子量:
- 88.11
- MOL File:
- 453-20-3.mol
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3-羟基四氢呋喃化学性质
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熔点:
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25°C
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沸点:
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181 °C (lit.)
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密度:
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1.09 g/mL at 25 °C (lit.)
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蒸气压:
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760 mm Hg ( 181 °C)
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折射率:
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n20/D 1.45(lit.)
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闪点:
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178 °F
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储存条件:
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Sealed in dry,Room Temperature
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酸度系数(pKa):
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14.49±0.20(Predicted)
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形态:
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Liquid
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颜色:
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Clear colorless to yellow
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比重:
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1.090
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水溶解性:
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500g/L(room temperature)
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稳定性:
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Stable. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides.
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InChIKey:
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XDPCNPCKDGQBAN-UHFFFAOYSA-N
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LogP:
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-0.830 (est)
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CAS 数据库:
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453-20-3(CAS DataBase Reference)
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NIST化学物质信息:
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Tetrahydrofuran, 3-hydroxy-(453-20-3)
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EPA化学物质信息:
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3-Furanol, tetrahydro- (453-20-3)
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3-羟基四氢呋喃性质、用途与生产工艺
用途
医药中间体。
生产方法
以1,2,4-丁三醇为原料合成3-羟基四氢呋喃的一般步骤如下：在间歇式反应器中，将1,2,4-丁三醇与等体积的二恶烷作为溶剂混合，并加入含有磺酸基的强酸离子交换树脂（Amberlyst 15，H+形式）作为催化剂。反应在大气压下，100℃的条件下进行20小时。反应完成后，3-羟基四氢呋喃的收率为96mol%。
参考文献：
[1] Patent: WO2005/121111, 2005, A1. Location in patent: Page/Page column 33
[2] Patent: WO2005/121111, 2005, A1. Location in patent: Page/Page column 33
[3] Patent: WO2007/81065, 2007, A1. Location in patent: Page/Page column 6
[4] Patent: WO2005/121111, 2005, A1. Location in patent: Page/Page column 31; 34
[5] Patent: WO2005/121111, 2005, A1. Location in patent: Page/Page column 33-34
3-羟基四氢呋喃
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2025/05/22 | 12194 | 3-羟基四氢呋喃
3-Hydroxytetrahydrofuran, 97%, Thermo Scientific Chemicals | 453-20-3 | 5g | 335元 |
| 2025/05/22 | 12194 | 3-羟基四氢呋喃
3-Hydroxytetrahydrofuran, 97%, Thermo Scientific Chemicals | 453-20-3 | 25g | 1202元 |
3-羟基四氢呋喃
生产厂家
全球有 319家供应商
3-羟基四氢呋喃国内生产厂家
453-20-3, 3-羟基四氢呋喃 相关搜索:
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- 3-羟基四氢呋喃标准品
- 好产品 3-羟基四氢呋喃
- 噁戊环-3-醇
- 3-羟基四氢呋喃,四氢呋喃-3-醇
- 3-羟基四氢呋喃 1G
- 3-羟基四氢呋喃,98%
- 3-羟基四氢呋喃
- 453-20-3
- -Hydroxytetrahydrofuran
- CAS No.453-20-3 3-Hydroxytetrahydrofuran
- 3-Hydroxytetrahydrofuran>
- 3-Hydroxytetrahydrofuran Vetec(TM) reagent grade, 98%
- 3-Hydroxytetrahydrofuran, 99%, 99%
- 3-Hydroxytetrahydrofuran ReagentPlus(R), 98%
- 3-Hydroxytetrahydrofuran, 97% 5GR
- 3-Hydroxytetrahydrofuran, 97% 25GR
- 3-Hydroxytetrahydrofuran,97%
- 3-HYDROXYTETRAHYDRAFURAN
- 3-Hydroxytetrahydrofurane
- 3-HYDROXYTETRAHYDROFURAN 99%
- Tetrahydro-3-furanol
- Tetrahydrofuran-3-ol
- tetrahydro-3-furano
- 3-hydroxyoxolane
- 3-Furanol, tetrahydro-
- 3-HYDROXYTETRAHYDROFURAN