ML303
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- CAS号:
- 1638211-04-7
- 英文名:
- 2-Methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenol
- 英文别名:
- ML303;ML303, 10 mM in DMSO;ML 303,Influenza Virus,ML-303,ML303,inhibit,Inhibitor;2-Methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenol;Phenol, 2-methoxy-4-[3-methyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazolo[3,4-b]pyridin-4-yl]-
- 中文名:
- ML303
- 中文别名:
- 化合物ML303;化合物ML303,10 MM DMSO 溶液;2-甲氧基-4-(3-甲基-1-(4-(三氟甲基)苯基)-1H-吡唑并[3,4-B]吡啶-4-基)苯酚
- CBNumber:
- CB82919205
- 分子式:
- C21H16F3N3O2
- 分子量:
- 399.37
- MOL File:
- 1638211-04-7.mol
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ML303化学性质
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沸点:
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483.6±45.0 °C(Predicted)
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密度:
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1.36±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: 20mg/mL, clear
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形态:
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powder
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酸度系数(pKa):
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8.01±0.20(Predicted)
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颜色:
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white to beige
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ML303性质、用途与生产工艺
ML303 是一种吡唑并吡啶类化合物， 是流感病毒非结构蛋白 1 (NS1) 的拮抗剂 (IC90 为 155 nM)，其对流感病毒H1N1亚型的 EC50 值为0.7 μM。
ML303 (20 μM, 6 h) treatment restore IFN-β mRNA levels in MDCK cells.
Western Blot Analysis
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Cell Line:
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MDCK cells infected with A/PR/8/34, at a MOI of 2, for 6 hours.
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Concentration:
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20 μM.
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Incubation Time:
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6 hours.
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Result:
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Restored IFN-β mRNA levels in MDCK cells.
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ML303
上下游产品信息
上游原料
下游产品
1638211-04-7, ML303 相关搜索:
- 抑制剂
- 药靶配体
- 化合物ML303,10 MM DMSO 溶液
- 2-甲氧基-4-(3-甲基-1-(4-(三氟甲基)苯基)-1H-吡唑并[3,4-B]吡啶-4-基)苯酚
- 化合物ML303
- 1638211-04-7
- ML303, 10 mM in DMSO
- Phenol, 2-methoxy-4-[3-methyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazolo[3,4-b]pyridin-4-yl]-
- ML 303,Influenza Virus,ML-303,ML303,inhibit,Inhibitor
- ML303
- 2-Methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenol