500794-88-7
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- CAS号:
- 500794-88-7
- 英文名:
- TR antagonist 1
- 英文别名:
- TR antagonist 1;Benzenepropanoic acid, 3,5-dibromo-4-[4-hydroxy-3-(1-methylethyl)-5-[(1E)-2-(4-pyridinyl)ethenyl]phenoxy]-
- 中文名:
- 500794-88-7
- 中文别名:
- TR 拮抗剂1;化合物 T13435
- CBNumber:
- CB84672641
- 分子式:
- C25H23Br2NO4
- 分子量:
- 561.26
- MOL File:
- 500794-88-7.mol
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500794-88-7化学性质
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沸点:
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636.5±55.0 °C(Predicted)
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密度:
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1.553±0.06 g/cm3(Predicted)
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储存条件:
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4°C, protect from light
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溶解度:
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DMSO : ≥ 83.3 mg/mL (148.42 mM)
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形态:
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Solid
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酸度系数(pKa):
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4.51±0.10(Predicted)
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颜色:
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Light yellow to yellow
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500794-88-7性质、用途与生产工艺
TR antagonist 1是高亲和力的甲状腺激素受体 (thyroid hormone receptor (TR)) 拮抗剂，对 TRα 和 TRβ 的IC50 值分别为 36 和 22 nM。
IC50: 36 nM (Thyroid hormone α), 22 nM (Thyroid hormone α)
TR antagonist 1 displays high affinity for both thyroid hormone TRα and TRβ (IC
50
=36 and 22 nM, respectively). TR antagonist 1 acts as a full antagonist in the TRAFR cell assay and the IC
50
32 nM for both TRAFα1 and TRAFβ1.
TR antagonist 1 treatment lowers heart rate and shows a possible trend toward an increase of low-density lipoprotein cholesterol (LDL-C) in the cholesterol fed rat model.
500794-88-7
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2025/05/22 | HY-111443 | TR antagonist 1 | 500794-88-7 | 1 mg | 2200元 |
| 2025/05/22 | HY-111443 | 500794-88-7
TR antagonist 1 | 500794-88-7 | 5mg | 5500元 |
500794-88-7, 500794-88-7 相关搜索:
- 抑制剂
- TR 拮抗剂1
- 化合物 T13435
- 500794-88-7
- Benzenepropanoic acid, 3,5-dibromo-4-[4-hydroxy-3-(1-methylethyl)-5-[(1E)-2-(4-pyridinyl)ethenyl]phenoxy]-
- TR antagonist 1