化合物 T10476
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- CAS号:
- 2471967-92-5
- 英文名:
- 1,6-Naphthyridine-6(5H)-carboxamide, N-[2-(4-fluorophenoxy)-5-pyrimidinyl]-5-(4-fluorophenyl)-7,8-dihydro-, (5S)-
- 英文别名:
- BAY-899;(5S)-N-[2-(4-fluorophenoxy)pyrimidin-5-yl]-5-(4-fluorophenyl)-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carboxamide;1,6-Naphthyridine-6(5H)-carboxamide, N-[2-(4-fluorophenoxy)-5-pyrimidinyl]-5-(4-fluorophenyl)-7,8-dihydro-, (5S)-
- 中文名:
- 化合物 T10476
- 中文别名:
- 化合物 T10476;化合物 BAY-899
- CBNumber:
- CB88186364
- 分子式:
- C25H19F2N5O2
- 分子量:
- 459.45
- MOL File:
- 2471967-92-5.mol
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化合物 T10476化学性质
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密度:
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1.397±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 1mg/mL, clear
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形态:
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Solid
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酸度系数(pKa):
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12.52±0.40(Predicted)
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颜色:
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White to off-white
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旋光度 (Optical Rotation):
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[α]/D 165 to 195°, c =1 in chloroform-d
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化合物 T10476性质、用途与生产工艺
BAY-899 是一种口服有效和选择性的促黄体生成激素受体 (LH-R) 拮抗剂，对 hLH (人 LH) 和 rLH (大鼠 LH) 的 IC50 分别为 185 nM 和 46 nM。BAY-899 可以降低性激素水平。
IC50: 185 nM (hLH) and 46nM (rLH)
BAY-899 (oral; 12.5 mg/kg/day; for 8 days) shows an efficiency to reduce serum estradiol levels in intact female rats.
BAY-899 (iv of 0.5 mg/kg or po of 2 mg/kg) has a t
1/2
of 11 hours and 12 hours for iv and po. And the C
max
is 0.97 kg/L and 0.24 kg/L for iv and po.
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Animal Model:
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Intact female rats
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Dosage:
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12.5 mg/kg
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Administration:
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Oral; for 8 days
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Result:
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Showed an efficiency to reduce serum estradiol levels.
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Animal Model:
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Female and male Wistar rats
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Dosage:
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0.5 mg/kg of iv or 2 mg/kg of po
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Administration:
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Iv or po
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Result:
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Has t
1/2
s of 11 hours and 12 hours for iv and po. And the C
max
s are 0.97 kg/L and 0.24 kg/L for iv and po.
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化合物 T10476
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2025/05/22 | HY-130248 | 化合物 T10476
BAY-899 | 2471967-92-5 | 5mg | 880元 |
| 2025/05/22 | HY-130248 | 化合物 T10476
BAY-899 | 2471967-92-5 | 10 mM * 1 mLin DMSO | 889元 |
2471967-92-5, 化合物 T10476 相关搜索:
- APIs
- 抑制剂
- C25H19F2N5O2
- 化合物 BAY-899
- 化合物 T10476
- 2471967-92-5
- (5S)-N-[2-(4-fluorophenoxy)pyrimidin-5-yl]-5-(4-fluorophenyl)-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carboxamide
- BAY-899
- 1,6-Naphthyridine-6(5H)-carboxamide, N-[2-(4-fluorophenoxy)-5-pyrimidinyl]-5-(4-fluorophenyl)-7,8-dihydro-, (5S)-