T67
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- CAS号:
- 195533-98-3
- 英文名:
- T67
- 英文别名:
- T67;T 67;T138067 Sodium;T 138067 Sodium;Batabulin sodium;Batabulin (sodium salt);Sodium (3-fluoro-4-methoxyphenyl)((perfluorophenyl)sulfonyl)amide;2-Fluoro-1-methoxy-4-((pentafluorophenyl)sulfonamido)benzene sodium salt;2,3,4,5,6-Pentafluoro-N-(3-fluoro-4-methoxyphenyl)benzenesulfonamide sodium salt;Benzenesulfonamide, 2,3,4,5,6-pentafluoro-N-(3-fluoro-4-methoxyphenyl)-, sodium salt
- 中文名:
- T67
- 中文别名:
- 巴他布林酸钠;化合物 BATABULIN SODIUM;巴他布林酸钠 Batabulin sodium;巴他布林酸钠 Batabulin sodium;(3-氟-4-甲氧基苯基)((全氟苯基)磺酰基)酰胺钠
- CBNumber:
- CB92496255
- 分子式:
- C13H6F6NNaO3S
- 分子量:
- 393.2368292
- MOL File:
- 195533-98-3.mol
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T67化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 125 mg/mL (317.87 mM)
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形态:
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A crystalline solid
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颜色:
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Off-white to light yellow
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T67性质、用途与生产工艺
Batabulin sodium (T138067 sodium) 是一种抗肿瘤剂，可与 β-微管蛋白同种型的子集共价且选择性地结合，从而破坏微管 (microtubule) 聚合。Batabulin sodium 影响细胞形态并导致细胞周期停滞，最终诱导凋亡性细胞死亡。
Batabulin (T138067; 30-300 nM; 24 hours; MCF7 cells) treatment shows approximately 25-30% tetraploid (4n) DNA content in cells, indicating an arrest at the G2/M cell-cycle boundary.
Batabulin (T138067; 30-300 nM; 24-48 hours; MCF7 cells) treatment shows 25-30% apoptosis. After a 48-hr exposure to 100 nM Batabulin, approximately 50-80% of the cell population is undergoing apoptosis.
Batabulin (T138067) binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Covalent modification occurs at a conserved Cys-239 shared by the β1, β2, and β4 tubulin isotypes. Cells exposed to Batabulin become altered in shape, indicating a collapse of the cytoskeleton, and show an increase in chromosomal ploidy.
Cell Cycle Analysis
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Cell Line:
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MCF7 cells
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Concentration:
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30 nM, 100 nM and 300 nM
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Incubation Time:
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24 hours
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Result:
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Showed an arrest at the G2/M cell-cycle boundary.
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Apoptosis Analysis
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Cell Line:
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MCF7 cells
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Concentration:
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30 nM, 100 nM and 300 nM
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Incubation Time:
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24 hours or 48 hours
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Result:
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25-30% of cells showed the reduced DNA content characteristic of apoptotic cells.
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Batabulin (T138067; 40 mg/kg; intraperitoneal injection; once per week; on days 5, 12, and 19; male athymic nude mice) treatment impairs the growth of the drug-sensitive CCRF-CEM tumors.
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Animal Model:
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Male athymic nude mice (
nu/nu
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CCRF-CEM cells
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Dosage:
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40 mg/kg
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Administration:
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Intraperitoneal injection; once per week; on days 5, 12, and 19
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Result:
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Impaired the growth of the drug-sensitive CCRF-CEM tumors.
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T67
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2025/05/22 | HY-13563A | T67
Batabulin sodium | 195533-98-3 | 5mg | 1500元 |
| 2025/05/22 | HY-13563A | T67
Batabulin sodium | 195533-98-3 | 10mM * 1mLin DMSO | 1650元 |
195533-98-3, T67 相关搜索:
- 抑制剂
- 巴他布林酸钠 Batabulin sodium
- 巴他布林酸钠 Batabulin sodium
- (3-氟-4-甲氧基苯基)((全氟苯基)磺酰基)酰胺钠
- 化合物 BATABULIN SODIUM
- 巴他布林酸钠
- 195533-98-3
- Sodium (3-fluoro-4-methoxyphenyl)((perfluorophenyl)sulfonyl)amide
- 2,3,4,5,6-pentafluoro-N-(3-fluoro-4-methoxyphenyl)-benzenesulfonamide, monosodium salt
- Batabulin (sodium salt)
- Batabulin sodiumQ: What is
Batabulin sodium Q: What is the CAS Number of
Batabulin sodium
- T67
- T138067 Sodium
- T 67
- T 138067 Sodium
- Benzenesulfonamide, 2,3,4,5,6-pentafluoro-N-(3-fluoro-4-methoxyphenyl)-, sodium salt
- Batabulin sodium
- 2-Fluoro-1-methoxy-4-((pentafluorophenyl)sulfonamido)benzene sodium salt
- 2,3,4,5,6-Pentafluoro-N-(3-fluoro-4-methoxyphenyl)benzenesulfonamide sodium salt