331862-41-0
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- CAS号:
- 331862-41-0
- 英文名:
- IMR-1A
- 英文别名:
- IMR-1A;IMR-1A, >98%;IMR-1A (IMR1A;IMR-1A ，S0225;IMR1A;IMR 1A;IMR-1A;IMR-1A, 10 mM in DMSO;Notch,Inhibitor,inhibit,IMR1A,IMR-1A,IMR 1A,Drug Metabolite;2-(2-Methoxy-4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetic acid;Acetic acid, 2-[2-methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-
- 中文名:
- 331862-41-0
- 中文别名:
- 化合物IMR-1A;IMR-1A ,S0225;NOTCH抑制剂(IMR-1A);化合物IMR-1A,10 MM DMSO 溶液;IMR-1A(IMR1A) |CAS 331862-41-0;IMR-1A【CAS：331862-41-0】【规格：5mg】【纯度：97%】;IMR-1A【CAS:331862-41-0】【规格:5mg】【纯度:97%】;2-(2-甲氧基-4-((4-氧代-2-硫代噻唑烷-5-亚基)甲基)苯氧基)乙酸
- CBNumber:
- CB93133188
- 分子式:
- C13H11NO5S2
- 分子量:
- 325.36
- MOL File:
- 331862-41-0.mol
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331862-41-0化学性质
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密度:
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1.55±0.1 g/cm3(Predicted)
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储存条件:
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under inert gas (nitrogen or Argon) at 2-8°C
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溶解度:
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DMSO:4.0(Max Conc. mg/mL);12.29(Max Conc. mM)
Water:1.0(Max Conc. mg/mL);3.07(Max Conc. mM)-
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形态:
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Solid
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酸度系数(pKa):
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3.10±0.10(Predicted)
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颜色:
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Light yellow to yellow
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331862-41-0性质、用途与生产工艺
IMR-1A 是IMR-1的酸性代谢产物，是一种 Notch 的有效的抑制剂，IC50值为0.5 μM，Kd值为2.9 μM。IMR-1A 具有抗肿瘤活性。
| Target | Value |
Notch
(Cell-free assay)
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0.5 μM
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Notch
(Cell-free assay)
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2.9 μM(Kd)
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IMR-1A (2 mg/kg (i.v.) and 100 mg/kg (i.p)) exhibits low systematic plasma clearance (CL = 7 mL/min/kg) with terminal elimination half-life (T1/2) of 2.22 h following a single i.v. administration. The normal liver blood flow in mice is 90 mL/min/kg and the Vss (volume of distribution) is ~4-fold. Plasma concentrations is quantifiable up to 24 h with Tmax of 0.50 h after i.p. administration.
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Animal Model:
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Male C57 BL/6 mice
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Dosage:
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2 mg/kg (i.v.) and 100 mg/kg (i.p)
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Administration:
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I.v. and i.p.
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Result:
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Exhibited low systematic plasma clearance (CL = 7 mL/min/kg) with terminal elimination half-life (T1/2) of 2.22 h following a single i.v. administration and plasma concentrations is quantifiable up to 24 h with Tmax of 0.50 h after i.p. administration.
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331862-41-0
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2025/09/19 | S0225 | 331862-41-0
IMR-1A | 331862-41-0 | 5mg | 3557.46元 |
| 2025/09/19 | S0225 | 331862-41-0
IMR-1A | 331862-41-0 | 25mg | 9928.47元 |
331862-41-0, 331862-41-0 相关搜索:
- 药物中间体
- 药靶配体
- 抑制剂
- 细胞生物学试剂
- 31862-41-0
- IMR-1A【CAS：331862-41-0】【规格：5mg】【纯度：97%】
- IMR-1A【CAS:331862-41-0】【规格:5mg】【纯度:97%】
- IMR-1A ,S0225
- IMR-1A(IMR1A) |CAS 331862-41-0
- 化合物IMR-1A,10 MM DMSO 溶液
- 2-(2-甲氧基-4-((4-氧代-2-硫代噻唑烷-5-亚基)甲基)苯氧基)乙酸
- 化合物IMR-1A
- NOTCH抑制剂(IMR-1A)
- 331862-41-0
- IMR-1A (IMR1A
- IMR-1A ，S0225
- IMR-1A, 10 mM in DMSO
- Notch,Inhibitor,inhibit,IMR1A,IMR-1A,IMR 1A,Drug Metabolite
- 2-(2-Methoxy-4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetic acid
- Acetic acid, 2-[2-methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-
- IMR-1A, >98%
- IMR1A;IMR 1A;IMR-1A
- IMR-1A