tert-Butyl 5-((2-(3-hydroxyphenyl)quinazolin-4-yl)amino)-1H-indazole-1-carboxylate

911417-26-0

CAS-Nr.: 911417-26-0

Englisch Name:: tert-Butyl 5-((2-(3-hydroxyphenyl)quinazolin-4-yl)amino)-1H-indazole-1-carboxylate

Synonyma:: Besudil impurity 18;Belumosudil Impurity 20;tert-butyl 5-((2-(3-hydroxyphenyl)quinazolin-4-yl)aMino)-1H-indazole-1-carboxylate;1,1-Dimethylethyl 5-[[2-(3-hydroxyphenyl)-4-quinazolinyl]amino]-1H-indazole-1-carboxylate;1H-Indazole-1-carboxylic acid, 5-[[2-(3-hydroxyphenyl)-4-quinazolinyl]aMino]-, 1,1-diMethylethyl ester

CBNumber:: CB12668146

Summenformel:: C26H23N5O3

Molgewicht:: 453.49

MOL-Datei:: 911417-26-0.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 17

tert-Butyl 5-((2-(3-hydroxyphenyl)quinazolin-4-yl)amino)-1H-indazole-1-carboxylate Eigenschaften

Siedepunkt:: 602.7±65.0 °C(Predicted)

Dichte: 1.32±0.1 g/cm3(Predicted)

pka: 9.20±0.10(Predicted)

InChI: InChI=1S/C26H23N5O3/c1-26(2,3)34-25(33)31-22-12-11-18(13-17(22)15-27-31)28-24-20-9-4-5-10-21(20)29-23(30-24)16-7-6-8-19(32)14-16/h4-15,32H,1-3H3,(H,28,29,30)

InChIKey: ZQJFYAJEBJLURU-UHFFFAOYSA-N

SMILES: N1(C(OC(C)(C)C)=O)C2=C(C=C(NC3=C4C(=NC(C5=CC=CC(O)=C5)=N3)C=CC=C4)C=C2)C=N1

Sicherheit

tert-Butyl 5-((2-(3-hydroxyphenyl)quinazolin-4-yl)amino)-1H-indazole-1-carboxylate Chemische Eigenschaften,Einsatz,Produktion Methoden

Synthese

To a solution of give tert-butyl 5-(2-(3-acetoxyphenyl)quinazolin-4-ylamino)-lH- indazole-l-carboxylate (5.85 g, 11.8 mmole) in anhydrous MeOH (400 mL) was added 28 % (wt/v) NH4OH solution (6.50 mL). The reaction mixture was stirred at ambient temperature for 48 h. The crude product was filtered and washed with ether followed by hexane and dried under high vacuum overnight to give tert-Butyl 5-((2-(3-hydroxyphenyl)quinazolin-4-yl)amino)-1H-indazole-1-carboxylate (1H-Indazole-1-carboxylic acid, 5-[[2-(3-hydroxyphenyl)-4-quinazolinyl]aMino]-, 1,1-diMethylethyl ester).

tert-Butyl 5-((2-(3-hydroxyphenyl)quinazolin-4-yl)amino)-1H-indazole-1-carboxylate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

4(3H)-Quinazolinone, 2-(3-hydroxyphenyl)- 1H-Indazole-1-carboxylic acid, 5-[[2-[3-(acetyloxy)phenyl]-4-quinazolinyl]amino]-, 1,1-dimethylethyl ester

Downstream Produkte

tert-Butyl 5-((2-(3-hydroxyphenyl)quinazolin-4-yl)amino)-1H-indazole-1-carboxylate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 17)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Hangzhou Qiwei Pharmatech Co.,Ltd	13282840061	mw@qwpharmatech.com	China	109	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Jinan Ruitong Biotech Co., Ltd.	+86-16615778970 +86-16615778970	info@ritonbio.com	China	511	58
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7552	61
Lanzhou Angeli Biochemical Technology Co., Ltd.	0931-8235634 13321316780	1455540579@qq.com	China	958	55
ChengDu TongChuangYuan Pharmaceutical Co.Ltd	028-83379370 13880556291	tcy@tcypharm.com	China	7218	58
Jinan Kabotang Biological Technology Co.,Ltd.	0531-61320525 15866703830	figo.gao@foxmail.com	China	5177	58
Shanghai Haohong Pharmaceutical Co., Ltd.	400-8210725 4008210725	malulu@leyan.com	China	55000	58
Hubei Xinyang Medical Technology Co., Ltd	15347293736 15347293736	2853117764@qq.com	China	10002	58
Shandong Mingde Biotechnology Co., Ltd	15553348166	m15553348166@163.com	China	9963	58

1H-Indazole-1-carboxylic acid, 5-[[2-(3-hydroxyphenyl)-4-quinazolinyl]aMino]-, 1,1-diMethylethyl ester
tert-butyl 5-((2-(3-hydroxyphenyl)quinazolin-4-yl)aMino)-1H-indazole-1-carboxylate
1,1-Dimethylethyl 5-[[2-(3-hydroxyphenyl)-4-quinazolinyl]amino]-1H-indazole-1-carboxylate
Besudil impurity 18
Belumosudil Impurity 20
911417-26-0