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Triflic Anhydride

Triflic Anhydride structure

CAS No.: 358-23-6

Chemical Name:: Triflic Anhydride

Synonyms: Tf2O;TRIFLIC ANHYDRIDE;Trifluoromethylsulfonic anhydride;trifluoromethylsulfonyl trifluoromethanesulfonate;TRIFLUOROMETHANESULFONIC ACID ANHYDRIDE;TRIFLUOROMETHANESULPHONIC ANHYDRIDE;Triflate Anhydride;TRIFLUOROMETHANESULFONYL ANHYDRIDE;(trifluoroMethane)sulfonyl trifluoroMethanesulfonate;Triflic acid anhydride

CBNumber:: CB00124391

Molecular Formula:: C2F6O5S2

Molecular Weight:: 282.14

MDL Number:: MFCD00000408

MOL File:: 358-23-6.mol

MSDS File:: SDS

Last updated:2026-03-02 16:41:49

Product description	Number	Pack Size	Price
Trifluoromethanesulfonic anhydride for synthesis	8.18043	2ml	$55
Trifluoromethanesulfonic anhydride for synthesis	8.18043	50mL	$368
Trifluoromethanesulfonic anhydride ≥99%	176176	1kg	$1570
Trifluoromethanesulfonic anhydride ≥99%	176176	4kg	$2130
Trifluoromethanesulfonic Anhydride >98.0%(T)	T1100	10g	$56
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Triflic Anhydride Properties

Melting point	-80°C
Boiling point	81-83 °C (lit.)
Density	1.677 g/mL at 25 °C (lit.)
vapor density	5.2 (vs air)
vapor pressure	8 mm Hg ( 20 °C)
refractive index	n20/D 1.321(lit.)
RTECS	PB2772000
Flash point	81-83°C
storage temp.	Store below +30°C.
solubility	Miscible with dichloromethane. Immiscible with hydrocarbons.
form	Liquid
color	Clear colorless to light brown
Specific Gravity	1.677
Water Solubility	reacts violently with water
Sensitive	Moisture Sensitive
BRN	1813600
Stability	Hygroscopic, Moisture Sensitive
InChI	1S/C2F6O5S2/c3-1(4,5)14(9,10)13-15(11,12)2(6,7)8
InChIKey	WJKHJLXJJJATHN-UHFFFAOYSA-N
SMILES	FC(F)(F)S(=O)(=O)OS(=O)(=O)C(F)(F)F
LogP	0.3 at 25℃
CAS DataBase Reference	358-23-6(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	8W034LHG1U
NIST Chemistry Reference	Trifluoromethanesulfonic anhydride(358-23-6)
EPA Substance Registry System	Methanesulfonic acid, trifluoro-, anhydride (358-23-6)
UNSPSC Code	12352106
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS03,GHS05,GHS07

Signal word

Danger

Hazard statements

H272-H302-H314-H335

Precautionary statements

P210-P220-P280-P301+P312-P303+P361+P353-P305+P351+P338

target organs

Respiratory system

PPE

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

14-21/22-34-35-22-40

Safety Statements

26-36/37/39-43-45-8

RIDADR

UN 3265 8/PG 2

WGK Germany

10-21

Hazard Note

Corrosive

TSCA

TSCA listed

HazardClass

PackingGroup

HS Code

29049020

Storage Class

5.1B - Oxidizing hazardous materials

Hazard Classifications

Acute Tox. 4 Oral
Eye Dam. 1
Ox. Liq. 2
Skin Corr. 1B
STOT SE 3

Toxicity

LD50 orally in Rabbit: 1012 mg/kg

Limited Quantities

1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)

NFPA 704

	1
3		2
	W

Triflic Anhydride price More Price(62)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	8.18043	Trifluoromethanesulfonic anhydride for synthesis	358-23-6	2ml	$55	2026-03-19	Buy
Sigma-Aldrich	8.18043	Trifluoromethanesulfonic anhydride for synthesis	358-23-6	50mL	$368	2026-03-19	Buy
Sigma-Aldrich	176176	Trifluoromethanesulfonic anhydride ≥99%	358-23-6	1kg	$1570	2026-03-19	Buy
Sigma-Aldrich	176176	Trifluoromethanesulfonic anhydride ≥99%	358-23-6	4kg	$2130	2026-03-19	Buy
TCI Chemical	T1100	Trifluoromethanesulfonic Anhydride >98.0%(T)	358-23-6	10g	$56	2026-03-19	Buy

Product number	Packaging	Price	Buy
8.18043	2ml	$55	Buy
8.18043	50mL	$368	Buy
176176	1kg	$1570	Buy
176176	4kg	$2130	Buy
T1100	10g	$56	Buy

Triflic Anhydride Chemical Properties,Uses,Production

Description

Triflic Anhydride is the acid anhydride derived from triflic acid. It is a strong electrophile, useful for introducing the triflyl group, CF3SO2.

Uses

Triflic anhydride is commonly used in organic chemistry to convert oxygen-containing compounds to triflates and for the electrophilic activation and subsequent conversion of amides, sulfoxides, and phosphorus oxides.

Preparation

Triflic anhydride is prepared by dehydration of triflic acid using P4O10.

Health Hazard

Triflic anhydride is readily hydrolyzes to the strong acid triflic acid, it is very harmful to skin and eyes.

Triflic Anhydride synthesis

Synthesis of Triflic Anhydride from Trifluoromethanesulfonic acid

Triflic Anhydride Preparation Products And Raw materials

Raw materials

Trifluoromethanesulfonic acid Phosphorus pentoxide Benzenesulfonic acid, 4-methyl-, anhydride with trifluoromethanesulfonic acid (9CI) bromine trifluoromethanesulfonate FLUOROTRIBROMOMETHANE

TRIFLUOROMETHANESULFONIC ACID TRIFLUOROMETHYL ESTER

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Preparation Products

5-AMINO-1,2,3-THIADIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER (S)-(-)-2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL Troglitazone 1-FLUORO-4-(TRIFLUOROMETHYLTHIO)BENZENE (S)-(-)-7,7'-BIS[DI(3,5-DIMETHYLPHENYL)PHOSPHINO]-2,2',3,3'-TETRAHYDRO-1,1'-SPIROBIINDANE

(S)-7,7'-Bis[di(p-methylphenyl)phosphino]-1,1'-spirobiindane ,97% (R)-(+)-7,7'-BIS[DI(4-METHYLPHENYL)PHOSPHINO]-2,2',3,3'-TETRAHYDRO-1,1'-SPIROBIINDANE (S)-(-)-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl 3,5-DIMETHYLISOXAZOL-4-YL ISOCYANATE (R)-(+)-7,7'-BIS(DIPHENYLPHOSPHINO)-2,2',3,3'-TETRAHYDRO-1,1'-SPIROBIINDANE

N-Phenyl-bis(trifluoromethanesulfonimide) 2-(TRIMETHYLSILYL)PHENYL TRIFLUOROMETHANESULFONATE (R)-(+)-TolBINAP 1-(3-AMINO-PYRIDIN-2-YL)-ETHANONE (R)-7,7'-BIS(DIPHENYLPHOSPHINO)-1,1'-SPIROBIINDANE

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Triflic Anhydride Suppliers

Global( 763)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
JIANGXI TIME PHARMACEUTICAL CO.,LTD	+86-0794-7183888 +86-13155888520	sales@groupchem.com	China	27	58
Henan Allgreen Chemical Co.,LTD	+86-37155567971 +86-13633837469	info@allgreenchem.com	China	5998	58
Fluoropharm Co., Ltd.	+86-0571-85586753 +86-13336034509	sales@fluoropharm.com	China	1445	60
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5742	58
Yurui(Shanghai) Chemical Co. Ltd	+86-02150456736 +86-17613296318	xin@riyngroup.com	China	288	58
QINGDAO KAIENSI INTERNATIONAL TRADE CO.,LTD.	+86-0532-86872187 +8615252467723	sales@knschem.com	China	166	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5235	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58

Supplier	Advantage
JIANGXI TIME PHARMACEUTICAL CO.,LTD	58
Henan Allgreen Chemical Co.,LTD	58
Fluoropharm Co., Ltd.	60
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
Yurui(Shanghai) Chemical Co. Ltd	58
QINGDAO KAIENSI INTERNATIONAL TRADE CO.,LTD.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Hebei Chuanghai Biotechnology Co., Ltd	58

What chemical reactions can occur with Trifluoromethanesulfonic anhydride?
Trifluoromethanesulfonic anhydride (Tf2O) is a strong electrophilic activator that can participate in a wide range of chemical....
Dec 16，2024

A useful reagent: Trifluoromethanesulfonic anhydride
Trifluoromethanesulfonic anhydride is employed as an electrophilic reagent for the conversion of various oxygen-containing com....
Dec 7，2023

Preparation of Trifluoromethanesulfonic anhydride.
Triflic anhydride is the chemical compound with the formula (CF3SO2)2O. It is the acid anhydride derived from triflic acid. Th....
Nov 6，2019

View Lastest Price from Triflic Anhydride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-08-16	triflic anhydride 358-23-6	US $80.00 / KG	1KG	>99%	20tons	Weijer International Trade (Hebei) Co., Ltd
2023-01-12	triflic anhydride 358-23-6	US $1.00 / KG	0.5KG	>99%	20tons	Anhui Rencheng Technology Co., Ltd
2021-03-17	triflic anhydride 358-23-6	US $60.00 / g	10g	99.8%	10tons	Hebei shuoxi biotechnology co. LTD

triflic anhydride
358-23-6
US $80.00 / KG
>99%
Weijer International Trade (Hebei) Co., Ltd

triflic anhydride
358-23-6
US $1.00 / KG
>99%
Anhui Rencheng Technology Co., Ltd

triflic anhydride
358-23-6
US $60.00 / g
99.8%
Hebei shuoxi biotechnology co. LTD

Trifluoromethanesulfonic anhydride Spectrum

Trifluoromethanesulfonic anhydride(358-23-6)MS Trifluoromethanesulfonic anhydride(358-23-6)¹HNMR Trifluoromethanesulfonic anhydride(358-23-6)¹³CNMR Trifluoromethanesulfonic anhydride(358-23-6)IR1 Trifluoromethanesulfonic anhydride(358-23-6)Raman

358-23-6(Triflic Anhydride)Related Search:

Trifluoromethanesulfonic acid Borane-trimethylamine complex Trifluoromethanesulfonamide Lanthanum trifluoromethanesulfonate Aluminum trifluoromethanesulfonate

YTTERBIUM(III) TRIFLUOROMETHANESULFONATE HYDRATE Sodium trifluoromethanesulfonate Trifluoromethanesulfonyl chloride SILVER TRIFLUOROMETHANESULFONATE Potassium trifluoromethanesulfonate

(Trifluoromethyl)trimethylsilane Lambda Cyhalotric Acid Zinc trifluoromethanesulfonate Ethyl trifluoromethanesulfonate TRIFLUOROMETHANESULFONIC ACID TRIFLUOROMETHYL ESTER

Methyl trifluoromethanesulfonate Trimethylsilyl trifluoromethanesulfonate 2-Bromoethyl trifluoromethanesulphonate Triflic Anhydride

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Trifluoromethanesulfonic anhydlladium(0) Trifluoromethanesulfonic anhydride purum, >=98.0% (T) Trifluoromethanesulfonic anhydride solution 1 M in methylene chloride Triflic anhydride solution 7561347, DT: 23.1 1.2016) RE-EXPORT TRIFLUOROMETHANE SULFONIC ANHYDRIDE(ORIG INAL IMPORT VIDE BE.NO Trifluoromethanesulfonic anhydride solution Methanesulfonic acid, trifluoro-, anhydride Perfluoromethanesulfonic anhydride Trifluoromethylsulfonic acid anhydride Trifluoromethanesulphonic anhydride, min. 97% Bis(trifluoromethanesulfonic)anhydride Bis(trifluoromethylsulfonyl) oxide Bis(trifluromethanesulfonic acid)anhydride TrifluoroMethanesulfonic anhydride, 98+% 10ML Tirflic Anhydride TRIFLUOROMETHANESULFONIC ANHYDRIDE FOR S Methanesulfonicacid, 1,1,1-trifluoro-, 1,1'-anhydride Three fluorineMethane sulfonylanhydride Three fluorine Methanesulfonic acid anhydride Perfluoromethanesulfonic anhydride solution TrifluoroMethanesulfonic anhydride, Tf2O Trifluromethanesulfonicanhydride Trifluoromethanessulfonic anhydride Trifluoromethanesulfonic anhydride, 99.5% TRIFLUOROMETHANESULFONIC ANHYDRIDETRIFLUOROMETHANESULFONIC ANHYDRIDETRIFLUOROMETHANESULFONIC ANHYDRIDETRIFLUOROMETHANESULFONIC ANHYDRIDE Methanesulfonicacid,trifluoro-,anhydride trifluoro-methanesulfonicacianhydride TRIFLUOROMETHANESULPHONIC ACID ANHYDRIDE TRIFLUOROMETHANESULFONIC ANHYDRIDE PFC-MSA TRIFLUOROMETHANESULFONIC ANHYDRIDE, 99+% TRIFLUOROMETHANESULFONIC ANHYDRIDE SET W ITH 10 X 1 ML TriFluoroMethaneSulfonic Anhydride（TFMSAA） Trifluoromethanesulfonicanhydride,98% Trifluoromethanesulphonicanhydride,min.97% Trifluoromethanesulphonic anhydride 99% Trifluoromethanesulphonicanhydride99% Trifluormethaansulfonzuur anhydride Trifluoromethanesufonic anhydride TRIFLIC ANHYDRIDE ( AKA ) TRIFLUOROMETHANE SULFONI TRIFLUOROMETHANESULFONIC ANHYDRIDE (TRIFLIC ANHYDRIDE) Trifluoromethanesulfonic anhydride 99% v Trifluoromethanesulfonic anhydride Trimethanesulfonoic acid anhydride fonic anhydride JACS-358-23-6 riflicanhydride TRIFLUOROMETHANESULPHONIC ANHYDRIDE For Synthesis Trifluoromethane anhydride Three trifluoromethyl sulfonic anhydride TRIFLUROMETHANESULFONIC ANHYDRIDE (TRIFLIC ANHYDRIDE) TRIFLUOROMETHANESULPHONIC ANHYDRIDE >98% Triflic Anhydride--TAA TRIFLIC ANHYDRIDE Trifluoromethanesulfonic acid anhydride Trifluoromethanesulfonic anhydride TRIFFLIC ANHYDRIDE TRIFLIC ANHYDRIDE (TRIFLUORO MEHTANESULFONIC ANHYDRIDE) Trifluoromethanesulphonic anhvdride