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TIROFIBAN HYDROCHLORIDE MONOHYDRATE

TIROFIBAN HYDROCHLORIDE MONOHYDRATE structure

CAS No.: 142373-60-2

Chemical Name:: TIROFIBAN HYDROCHLORIDE MONOHYDRATE

Synonyms: Tirofiban Hydrochloride;butoxy);L 700462;4-Dihydroxypyridine;-3-(4-(4-(piperidin-4-yl);TirofibanhydrochlorideHCl;Tirofiban hydrochloride 1-hydrate;Tirofiban hydrochloride (L700462);Tirofiban hydrochloride monohydrate Tirofiban Hydrochloride;N-(Butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-L-tyrosine hydrochloride

CBNumber:: CB0100160

Molecular Formula:: C22H39ClN2O6S

Molecular Weight:: 495.07

MDL Number:: MFCD00868210

MOL File:: 142373-60-2.mol

MSDS File:: SDS

Last updated:2026-05-27 17:22:49

Product description	Number	Pack Size	Price
TIROFIBAN HYDROCHLORIDE 98	AA00HWEN	10mg	$97
TIROFIBAN HYDROCHLORIDE 98	AA00HWEN	100mg	$142
TIROFIBAN HYDROCHLORIDE 98.00	AA00HWEN	1g	$838
(S)-2-(Butylsulfonamido)-3-(4-(4-(piperidin-4-yl)butoxy)phenyl)propanoic acid hydrochloride 97%	CD21014226	250mg	$473
(S)-2-(Butylsulfonamido)-3-(4-(4-(piperidin-4-yl)butoxy)phenyl)propanoic acid hydrochloride 97%	CD21014226	1g	$1186
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TIROFIBAN HYDROCHLORIDE MONOHYDRATE Properties

Melting point	83-87oC
solubility	Methanol (Slightly)
form	Solid
color	White
InChIKey	HWAAPJPFZPHHBC-MGIYCFTINA-N
SMILES	S(CCCC)(=O)(=O)N[C@@H](CC1=CC=C(C=C1)OCCCCC1CCNCC1)C(O)=O.Cl.O \|&1:8,r\|
CAS DataBase Reference	142373-60-2
EWG's Food Scores	1
FDA UNII	IKE1P4X57J

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

TIROFIBAN HYDROCHLORIDE MONOHYDRATE price More Price(19)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
aablocks	AA00HWEN	TIROFIBAN HYDROCHLORIDE 98	142373-60-2	10mg	$97	2026-05-29	Buy
aablocks	AA00HWEN	TIROFIBAN HYDROCHLORIDE 98	142373-60-2	100mg	$142	2026-05-29	Buy
aablocks	AA00HWEN	TIROFIBAN HYDROCHLORIDE 98.00	142373-60-2	1g	$838	2026-05-29	Buy
Crysdot	CD21014226	(S)-2-(Butylsulfonamido)-3-(4-(4-(piperidin-4-yl)butoxy)phenyl)propanoic acid hydrochloride 97%	142373-60-2	250mg	$473	2026-05-27	Buy
Crysdot	CD21014226	(S)-2-(Butylsulfonamido)-3-(4-(4-(piperidin-4-yl)butoxy)phenyl)propanoic acid hydrochloride 97%	142373-60-2	1g	$1186	2026-05-27	Buy

Product number	Packaging	Price	Buy
AA00HWEN	10mg	$97	Buy
AA00HWEN	100mg	$142	Buy
AA00HWEN	1g	$838	Buy
CD21014226	250mg	$473	Buy
CD21014226	1g	$1186	Buy

TIROFIBAN HYDROCHLORIDE MONOHYDRATE Chemical Properties,Uses,Production

Description

Tirofiban was launched as Aggrastat in Switzerland and the US for patients with unstable angina or non-Q-wave myocardial infarction to prevent cardiac ischemic events. Tirofiban is synthesized from (S)-tyrosine by a fourstep process. Tirofiban is a novel highly potent antiplatelet agent that inhibits the interaction of fibrinogen with GPⅡb/Ⅲa, an activated platelet membrane-bound glycoprotein complex. It prevents arterial thrombus formation in a dosedependent manner. Clinical efficacy was highly significant with an absolute and relative risk reduction. In these studies, treatment with tirofiban was well tolerated, without significant adverse effects.

Originator

Sibutramine (Sibutramine)

Uses

Aggrastat (Millot Laboratories, France).

Uses

Tirofiban Hydrochloride is a selective nonpeptide platelet glycoprotein IIb/IIIa antagonist.

Manufacturing Process

The synthesis of tirofiban starts by reaction of tyrosine with bis-trimethylsilyl trifluoraceramide to give a derivative in which both functions -OH and COOH_x0002_are protected. Treatment of this intermediate with butylsulfonyl chloride gives the corresponding sulfonamide derivative; the quite labile silyl groups are then removed under mildly acidic conditions to give N-butylsulfonyl-tyrosine. In a parallel scheme, 4-picoline is converted to its anion by means of butyl lithium; this gives 4-(4-chlorobutyl)-pyridine on alkylation with 1-bromo-3- chloropropane. The reaction of this compound with N-butylsulfonyl-tyrosine in presence of NaOH gives the ether 2-butylsulfonyaminol-3-[4-pyridin-4-ylbutoxy-phenyl]propionic acid. Hydrogenation over palladium on charcoal then reduce the pyridine ring to a piperidine to afford the fibrinogen receptor antagonist tirofiban.

brand name

Tirofiban is INN and BAN.

Therapeutic Function

Fibrinogen receptor antagonist

TIROFIBAN HYDROCHLORIDE MONOHYDRATE Preparation Products And Raw materials

Raw materials

n-Butyllithium 1-Bromo-3-chloropropane 4-Methylpyridine Palladium hydroxide L-Tyrosine

1-Butanesulfonyl chloride

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Preparation Products

TIROFIBAN HYDROCHLORIDE MONOHYDRATE Suppliers

Global( 123)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21587	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	18903	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52705	58
CD Chemical Group Limited	+8615986615575	info@codchem.com	China	17259	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19908	58
Alfa Chemistry	+1-5166625404;	Info@alfa-chemistry.com	United States	20405	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
CONIER CHEM AND PHARMA LIMITED	58
SIMAGCHEM CORP	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
CD Chemical Group Limited	58
Nextpeptide Inc	58
Alfa Chemistry	58

View Lastest Price from TIROFIBAN HYDROCHLORIDE MONOHYDRATE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-11-18	TIROFIBAN HYDROCHLORIDE MONOHYDRATE USP/EP/BP 142373-60-2	$1.10	1g	99.9%	100 Tons min	Dideu Industries Group Limited
2020-05-12	Tirofiban hydrochloride 142373-60-2		1KG	99.0%	500 MT	Shaanxi Dideu Medichem Co. Ltd
2019-07-06	TIROFIBAN HYDROCHLORIDE MONOHYDRATE 142373-60-2	$2.00	1kg	99%	100kg	Career Henan Chemical Co

TIROFIBAN HYDROCHLORIDE MONOHYDRATE USP/EP/BP
142373-60-2
$1.10
99.9%
Dideu Industries Group Limited

Tirofiban hydrochloride
142373-60-2
99.0%
Shaanxi Dideu Medichem Co. Ltd

TIROFIBAN HYDROCHLORIDE MONOHYDRATE
142373-60-2
$2.00
99%
Career Henan Chemical Co

142373-60-2(TIROFIBAN HYDROCHLORIDE MONOHYDRATE)Related Search:

Tirofiban hydrochloride monohydrate L-N-BUTYLSULFONYL-P-HYDROXYPHENYLALANINE Tirofiban IMpurity (4,4'-Dipyridyl-1,5-Pentane) tirofiban N-Butylsulfonyl-O-(4-(4-pyridinyl)butyl)-L-tyrosine

4-PYRIDIN-4-YL-BUTAN-1-OL 1-Butanesulfonic acid methyl ester 4-PYRIDIN-4-YL-BUTYRIC ACID Sodium 1-butanesulfonate 1-Methylethyl 1-butanesulfonate

METHYL N-BUTYLSULFONYL-L-P-HYDROXYPHENYLALANINE tirofiban tirofiban 1-Butanesulfonyl chloride 4-(4-Piperidyl)-1-butanol

2-butyl-4-methylpyridine 4,4'-Dimethyl-2,2'-bipyridyl 4-Chloro-1-butanol

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L 700462 L-Tyrosine, N-(butylsulfonyl)-o-(4-(4-piperidinyl)butyl)-, monohydrochloride N-(Butylsulfonyl)-o-(4-(4-piperidinyl)butyl)-L-tyrosine monohydrochloride 2-(butylsulfonaMido)-3-(4-(4-(piperidin-4-yl)butoxy)phenyl)propanoic acid L-Tyrosine,N-(butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-, hydrochloride (1:1) -3-(4-(4-(piperidin-4-yl) butoxy) N-(Butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-L-tyrosine hydrochloride TirofibanhydrochlorideHCl (S)-2-(Butylsulfonamido)-3-(4-(4-(piperidin-4-yl)butoxy)phenyl)propanoic acid hydrochloride Tirofiban hydrochloride monohydrate Tirofiban Hydrochloride 2-(butylsulfonylamino)-3-[4-[4-(4-piperidinyl)butoxy]phenyl]propanoic acid hydrochloride (S)-2-(Butylsulfonamido)-3-(4-(4-(piperidin-4-yl)butoxy)phenyl)propanoic acid Tirofiban hydrochloride 1-hydrate Tirofiban hydrochloride (L700462) 4-Dihydroxypyridine Tirofiban Hydrochloride 142373-60-2 C22H36N2O5SHCl C22H36N2O5SHClH2O C22H39ClN2O6S C23H40ClNO6S C22H36N2O5SClH