Seneciphylline
- CAS No.
- 480-81-9
- Chemical Name:
- Seneciphylline
- Synonyms
- JACODINE;NSC 30622;Aids002697;NCI-C-61165;Aids-002697;α-Longilobin;SENECIPHYLLIN;Seneciphynine;seneciphylline;seneciophylline
- CBNumber:
- CB0103055
- Molecular Formula:
- C18H23NO5
- Molecular Weight:
- 333.38
- MDL Number:
- MFCD00221722
- MOL File:
- 480-81-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Seneciphylline phyproof? Reference Substance | PHL89275 | 10mg | $575 |
| Seneciphylline analytical standard | 73913 | 5mg | $657 |
| Seneciphylline ≥98% | 25146 | 1mg | $41 |
| Seneciphylline ≥98% | 25146 | 5mg | $186 |
| Seneciphylline ≥98% | 25146 | 10mg | $312 |
| More product size | |||
| Melting point | 217°C |
|---|---|
| alpha | D -128° (chloroform) |
| Boiling point | 470.34°C (rough estimate) |
| Density | 1.2467 (rough estimate) |
| refractive index | 1.5740 (estimate) |
| storage temp. | -20°C |
| solubility | DMF: 5 mg/ml; DMSO: 2 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 0.1 mg/ml |
| pka | 12.43±0.20(Predicted) |
| form | Solid |
| color | White to off-white |
| Stability | Stable, but reacts with oxygen in the air. Incompatible with alkali, oxidizing agents. Store under inert gas. |
| LogP | 0.810 (est) |
| CAS DataBase Reference | 480-81-9 |
| EWG's Food Scores | 1 |
| FDA UNII | 0ZYZ9L5454 |
| IARC | 3 (Vol. 10, Sup 7) 1987 |
| EPA Substance Registry System | Seneciphylline (480-81-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300+H310+H330 | |||||||||
| Precautionary statements | P260-P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 23/24/25-25 | |||||||||
| Safety Statements | 1-20-24/25-45 | |||||||||
| RIDADR | 1544 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| Hazardous Substances Data | 480-81-9(Hazardous Substances Data) | |||||||||
| NFPA 704 |
|
Seneciphylline price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL89275 | Seneciphylline phyproof? Reference Substance | 480-81-9 | 10mg | $575 | 2026-04-30 | Buy |
| Sigma-Aldrich | 73913 | Seneciphylline analytical standard | 480-81-9 | 5mg | $657 | 2022-05-15 | Buy |
| Cayman Chemical | 25146 | Seneciphylline ≥98% | 480-81-9 | 1mg | $41 | 2026-04-30 | Buy |
| Cayman Chemical | 25146 | Seneciphylline ≥98% | 480-81-9 | 5mg | $186 | 2026-04-30 | Buy |
| Cayman Chemical | 25146 | Seneciphylline ≥98% | 480-81-9 | 10mg | $312 | 2026-04-30 | Buy |
Seneciphylline Chemical Properties,Uses,Production
Description
Seneciphylline, a pyrrolizidine alkaloid, one of the main components of Chinese medicine herb Tusanqi, which is a reason of the hepatic sinusoidal obstruction syndrome (HSOS). In addition, experiments on rats have shown that seneciphylline had adverse effects on the development and organic morphodifferentiation of embryos, thus the pregnant people exposed to Hebra may get potential risk on the fetus.
Chemical Properties
White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, Derived from the whole plant or root of Gynura segetum (Lour.) Merr (Ju Sanqi).
Uses
Seneciphylline is a minor constituent of S. jacobaea, which has been used as a medicinal herb in Europe. It has the effect of coagulation and hemostasis.
Seneciphylline is a pyrrolizidine alkaloid with the potential to affect hepatic drug metabolizing enzymes in rat cells.
Application
Seneciphylline is a naturally occurring plant toxin, which is employed to defend the plant against herbivore and insect attacks.
Seneciphylline may be used as an analytical reference standard for the quantification of the analyte in feed samples and traditional Chinese herbal medicines using different chromatography techniques.
Definition
ChEBI: LSM-2853 is a citraconoyl group.
Air & Water Reactions
Reacts slowly with atmospheric oxygen. . Insoluble in water.
Reactivity Profile
SENECIPHYLLIN is readily hydrolyzed with alkali; SENECIPHYLLIN reacts readily with oxidizing agents .
Health Hazard
Seneciphylline and aflatoxin B. may be of greater importance as a cause of human disease than the presently known outbreaks of poisoning would indicate.
SYMPTOMS: Symptoms associated with this compound include abdominal pain, nausea and diarrhea, emaciation, intestinal edema and congestion of the liver. ACUTE/CHRONIC HAZARDS: Very toxic. (NTP, 1992)
Fire Hazard
Flash point data are not available for SENECIPHYLLIN, but SENECIPHYLLIN is probably combustible.
Synthesis
Take 1kg of raw materials of Chirimenosha herbs, crush to 20 mesh, add 90% ethanol solution reflux extraction for 3 times, combined extract, add 0.8% of its volume of activated carbon decolorization, filtration to get decolorized liquid, decolorized liquid concentration to extract, extract dissolved with 5% hydrochloric acid solution, filtration, filtrate on the D151 cation exchange resin, the first deionized water to neutral, then elute with 4LpH11 75% ethanol solution elution, eluent concentration under reduced pressure, adjust pH 10, placed on the crystallization, filtration to get the crystals, the crystals with acetone reflux dissolved, while hot filtration, cooling crystals, filtered crystals drying that is the product of 5.3g, the content of 88.7%.
Seneciphylline Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253; +8618283602253 | jancyzheng@gcgreenpure.com | China | 954 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Fengjia New Material Co., Ltd | +86-0311-87836622 +86-18712993135 | sales01@tairunfaz.com | China | 8051 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21588 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29816 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3751 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
View Lastest Price from Seneciphylline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-22 | Seneciphylline
480-81-9
|
US $48.00-228.00 / mg | 99.84% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-03-20 | SENECIPHYLLIN
480-81-9
|
US $1.00 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-05-26 | SENECIPHYLLIN
480-81-9
|
US $2.00 / kg | 1kg | 0.99 | 10000 | Hebei Fengjia New Material Co., Ltd |
-
- Seneciphylline
480-81-9
- US $48.00-228.00 / mg
- 99.84%
- TargetMol Chemicals Inc.
-
- SENECIPHYLLIN
480-81-9
- US $1.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- SENECIPHYLLIN
480-81-9
- US $2.00 / kg
- 0.99
- Hebei Fengjia New Material Co., Ltd
