Uses
Thymidine 3',5'-diphosphate (Deoxythymidine 3′,5′-diphosphate) tetrasodium is a selective inhibitor of staphylococcal nuclease and tudor domain containing 1 (SND1, the MicroRNA regulatory complex RISC subunit) and [3,5-2H2] tyrosyl nuclease. Thymidine 3',5'-diphosphate tetrasodium has anti-tumor activity and can also be used as a catalyst in biochemical reactions[1][2].
in vivo
Thymidine 3',5'-diphosphate tetrasodium (0.8 mg/kg; i.p.; twice a week for 4 weeks) has insignificant effect on serum liver enzymes (AST, ALT, AP), total protein (TP), albumin (Alb), and globulin (Glo) in WT B6/CBA mice[1].
Thymidine 3',5'-diphosphate tetrasodium (0.8 mg/kg and 1.6 mg/kg; i.v.; twice a week for 4 weeks) significantly inhibits tumor growth in WT B6/CBA mice[1].
Thymidine 3',5'-diphosphate tetrasodium (0.8, 0.16 and 0.32 mg/kg; s.c.; twice a week for 4 weeks) inhibits tumor growth, inflammatory reaction and the expression of tumor initiating cells (TIC) markers in adult male NSG mice. Thymidine 3',5'-diphosphate tetrasodium up-regulates the expression of PTEN, TGFBR2 and CDKN1C apoptosis and selective tumor suppressor genes[1].
| Animal Model: | 2 months old WT B6/CBA mice[1]. |
| Dosage: | 0.8 mg/kg. |
| Administration: | Intraperitoneal injection; twice a week for 4 weeks. |
| Result: | Had insignificant effect on serum liver enzymes, total protein, albumin and globulin and showed biosafety. |
| Animal Model: | NSG mice[1]. |
| Dosage: | 0.8, 0.16 or 0.32 mg/kg. |
| Administration: | Intravenous injection or subcutaneous injection; twice a week for 4 weeks. |
| Result: | Inhibited tumor growth, showed antitumor activity and immunomodulatory effects.
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References
[1] Nidhi Jariwala, et al. Oncogenic Role of SND1 in Development and Progression of Hepatocellular Carcinoma. Cancer Res. 2017 Jun 15;77(12):3306-3316. DOI:10.1158/0008-5472.CAN-17-0298
[2] Cohen J S, et al. Proton magnetic resonance studies of the tyrosine residues of staphylococcal nuclease using [3, 5-2H2] tyrosine[J]. Biochimica et Biophysica Acta (BBA)-Protein Structure, 1971, 236(2): 468-478.
