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ChemicalBook >> CAS DataBase List >>1H-Indene-5-acetic acid, 2-[[[(4-chlorophenyl)sulfonyl]amino]methyl]-2,3-dihydro-, sodium salt (1:1)

1H-Indene-5-acetic acid, 2-[[[(4-chlorophenyl)sulfonyl]amino]methyl]-2,3-dihydro-, sodium salt (1:1)

1H-Indene-5-acetic acid, 2-[[[(4-chlorophenyl)sulfonyl]amino]methyl]-2,3-dihydro-, sodium salt (1:1) Structure
1H-Indene-5-acetic acid, 2-[[[(4-chlorophenyl)sulfonyl]amino]methyl]-2,3-dihydro-, sodium salt (1:1) structure
CAS No.
146731-14-8
Chemical Name:
1H-Indene-5-acetic acid, 2-[[[(4-chlorophenyl)sulfonyl]amino]methyl]-2,3-dihydro-, sodium salt (1:1)
Synonyms
Z-335 sodium;Z 335 sodium,Z335 sodium;1H-Indene-5-acetic acid, 2-[[[(4-chlorophenyl)sulfonyl]amino]methyl]-2,3-dihydro-, sodium salt (1:1)
CBNumber:
CB010453139
Molecular Formula:
C18H19ClNNaO4S
Molecular Weight:
403.85
MDL Number:
MFCD00941373
MOL File:
146731-14-8.mol
Last updated:2025-04-18 09:51:23
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1H-Indene-5-acetic acid, 2-[[[(4-chlorophenyl)sulfonyl]amino]methyl]-2,3-dihydro-, sodium salt (1:1) Chemical Properties,Uses,Production

Description

Z-335 Salt is a thromboxane A2 receptor antagonist potentially for the treatment of arterial occlusive disease.

Uses

Z-335 sodium is an orally active thromboxane a2 (TXA2) receptor antagonist, with IC50 values of 29.9 nM and 32.5 nM for human and Guinea pig platelets, respectively[1][2].

in vivo

Z-335 (0.3-3 mg/kg, p.o.) inhibits thrombus formation in a dose-dependent manner[2].
Z-335 (3 mg/kg, p.o.) significantly prevents thrombus formation even at 16 h [2].

References

[1] T Tanaka, et al. Antiplatelet effect of Z-335, a new orally active and long-lasting thromboxane receptor antagonist. Eur J Pharmacol. 1998 Sep 11;357(1):53-60. DOI:10.1016/s0014-2999(98)00540-8
[2] T Tanaka, et al. Z-335, a new thromboxane A(2) receptor antagonist, prevents arterial thrombosis induced by ferric chloride in rats. Eur J Pharmacol. 2000 Aug 11;401(3):413-8. DOI:10.1016/s0014-2999(00)00434-9

1H-Indene-5-acetic acid, 2-[[[(4-chlorophenyl)sulfonyl]amino]methyl]-2,3-dihydro-, sodium salt (1:1) Preparation Products And Raw materials

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Preparation Products

1H-Indene-5-acetic acid, 2-[[[(4-chlorophenyl)sulfonyl]amino]methyl]-2,3-dihydro-, sodium salt (1:1) Suppliers

Global( 5)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		support@targetmol.com United States 38663 58
Wuhan Han Sheng New Material Technology Co.，Ltd 		+8617798174412 admin01@hsnm.com.cn China 2097 58
TargetMol Chemicals Inc. 		+8613564774135 zijue.cai@tsbiochem.com United States 19905 58
Suzhou Meishi Biotechnology Co., Ltd. 1173954148q meishipharma@126.com China 20033 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 19965 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Wuhan Han Sheng New Material Technology Co.，Ltd 		58
TargetMol Chemicals Inc. 		58
Suzhou Meishi Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58

View Lastest Price from 1H-Indene-5-acetic acid, 2-[[[(4-chlorophenyl)sulfonyl]amino]methyl]-2,3-dihydro-, sodium salt (1:1) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Z-335 sodium pictures 2024-10-28 Z-335 sodium
146731-14-8
 US $1980.00-1520.00 / mg 10g TargetMol Chemicals Inc.
  • Z-335 sodium pictures
  • Z-335 sodium
    146731-14-8
  • US $1980.00-1520.00 / mg
  • TargetMol Chemicals Inc.
1H-Indene-5-acetic acid, 2-[[[(4-chlorophenyl)sulfonyl]amino]methyl]-2,3-dihydro-, sodium salt (1:1) Z-335 sodium Z 335 sodium,Z335 sodium 146731-14-8 C18H19ClNNaO4S