Piperazinone, 3-(2-thienyl)- (9CI)
- CAS No.
- 86696-86-8
- Chemical Name:
- Piperazinone, 3-(2-thienyl)- (9CI)
- Synonyms
- Tenilsetam;3-(2-thienyl)- (9CI);Tenilsetam/Piperazinone;Tenilsetam, 10 mM in DMSO;3-(2-Thienyl)-2-piperazinone;3-(2-Thienyl)piperazin-2-one;2-Piperazinone, 3-(2-thienyl)-;Piperazinone, 3-(2-thienyl)- (9CI);Tenilsetam - PAS 997 | CAS 997 | HR 029;Piperazinone, 3-(2-thienyl)- (9CI) USP/EP/BP
- CBNumber:
- CB01052655
- Molecular Formula:
- C8H10N2OS
- Molecular Weight:
- 182.24
- MDL Number:
- MFCD00867779
- MOL File:
- 86696-86-8.mol
| Density | 1.225 |
|---|---|
| InChI | InChI=1S/C8H10N2OS/c11-8-7(9-3-4-10-8)6-2-1-5-12-6/h1-2,5,7,9H,3-4H2,(H,10,11) |
| InChIKey | BBACKDMGYMXYLE-UHFFFAOYSA-N |
| SMILES | N1CCNC(C2SC=CC=2)C1=O |
| FDA UNII | O4Q7XM74N6 |
Piperazinone, 3-(2-thienyl)- (9CI) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B587980 | 3-(thiophen-2-yl)piperazin-2-one | 86696-86-8 | 10mg | $45 | 2021-12-16 | Buy |
| Axon Medchem | Axon1470 | Tenilsetam-PAS997|CAS997|HR029 99% | 86696-86-8 | 50mg | $198 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0010538 | 3-(2-THIENYL)-2-PIPERAZINONE 95.00% | 86696-86-8 | 10MG | $275.1 | 2021-12-16 | Buy |
| Matrix Scientific | 134199 | 3-(Thiophen-2-yl)piperazin-2-one 95%+ | 86696-86-8 | 500mg | $684 | 2021-12-16 | Buy |
| Matrix Scientific | 134199 | 3-(Thiophen-2-yl)piperazin-2-one 95%+ | 86696-86-8 | 2.500g | $1374 | 2021-12-16 | Buy |
Piperazinone, 3-(2-thienyl)- (9CI) Chemical Properties,Uses,Production
Description
Tenilsetam ((+/-)-3-(2-thienyl)-2-piperazinone; Piperazinone, 3-(2-thienyl)- (9CI)), a cognition-enhancing drug successfully used for the treatment of patients suffering from Alzheimer's disease, when included in the Maillard reaction inhibits protein crosslinking by AGEs in vitro. According to the mechanism proposed, Tenilsetam acts via covalent attachment to glycated proteins, thus blocking the reactive sites for further polymerisation reactions. A beneficial effect of Tenilsetam in Alzheimer's disease could come from the interference with AGE-derived crosslinking of amyloid plaques and a decreased inflammatory response by diminished activation of phagocytosing microglia[1].
Uses
Tenilsetam (CAS 997) is an antidementia compound. Tenilsetam is an advanced glycation end product (AGE) inhibitor. Tenilsetam inhibits early retinopathy in experimental diabetes rats[1][2].
References
[1] G Münch. “The cognition-enhancing drug tenilsetam is an inhibitor of protein crosslinking by advanced glycosylation.” Journal of Neural Transmission - Parkinson’s Disease and Dementia Section 8 3 (1994): 193–208.
Piperazinone, 3-(2-thienyl)- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
Piperazinone, 3-(2-thienyl)- (9CI) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 | |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29807 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22866 | 58 |
| Wuhan Han Sheng New Material Technology Co.，Ltd | +8617798174412 | admin01@hsnm.com.cn | China | 2097 | 58 |
| Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +8615988602810 | sales@anbuchem.com | China | 2998 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Amatek Scientific Co. Ltd. | 0512-56316828 | info@amateksci.com | China | 28803 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
View Lastest Price from Piperazinone, 3-(2-thienyl)- (9CI) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Tenilsetam
86696-86-8
|
US $80.00-272.00 / mg | 99.52% | 10g | TargetMol Chemicals Inc. | ||
 |
2021-07-07 | Piperazinone, 3-(2-thienyl)- (9CI) USP/EP/BP
86696-86-8
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2020-01-10 | Piperazinone, 3-(2-thienyl)- (9CI)
86696-86-8
|
US $1.00 / g | 1g | 99.0% | 100kg | Career Henan Chemical Co |
-
- Tenilsetam
86696-86-8
- US $80.00-272.00 / mg
- 99.52%
- TargetMol Chemicals Inc.
-
- Piperazinone, 3-(2-thienyl)- (9CI) USP/EP/BP
86696-86-8
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- Piperazinone, 3-(2-thienyl)- (9CI)
86696-86-8
- US $1.00 / g
- 99.0%
- Career Henan Chemical Co