ChemicalBook >> CAS DataBase List >>1H-Indole-6-carboxamide, 1-[(2-chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-

1H-Indole-6-carboxamide, 1-[(2-chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-

1H-Indole-6-carboxamide, 1-[(2-chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]- structure

CAS No.: 2259624-71-8

Chemical Name:: 1H-Indole-6-carboxamide, 1-[(2-chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-

Synonyms: C53;STING agonist C53;STING activator Compound 53;STING activator Compound 53, 10 mM in DMSO;1-(2-chloro-6-fluorobenzyl)-3,3-dimethyl-2-oxo-N-(2,4,6-trifluorobenzyl)indoline-6-carboxamide;1-[(2-chloro-6-fluoro-phenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]indoline-6-carboxamide;1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide;1H-Indole-6-carboxamide, 1-[(2-chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-;Inhibitor,HEK293T,STING agonist-12,MPYS,STING agonist12,STING,STING agonist 12,STING activator Compound 53,TMEM173,inhibit,ERIS,Stimulator of Interferon Genes,MITA

CBNumber:: CB010785689

Molecular Formula:: C25H19ClF4N2O2

Molecular Weight:: 490.88

MDL Number:

MOL File:: 2259624-71-8.mol

Last updated:2025-04-17 18:22:24

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1H-Indole-6-carboxamide, 1-[(2-chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]- Properties

Boiling point	628.4±55.0 °C(Predicted)
Density	1.392±0.06 g/cm3(Predicted)
storage temp.	4°C, protect from light
solubility	DMSO : 250 mg/mL (509.29 mM; Need ultrasonic)
form	A crystalline solid
pka	13.31±0.40(Predicted)
color	Light yellow to yellow

1H-Indole-6-carboxamide, 1-[(2-chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]- Chemical Properties,Uses,Production

Uses

STING agonist-12 (Compound 53) is a potent, orally active human STING activator with an EC50 of 185 nM[1].

Biological Activity

STING agonist-12 (Compound 53) is a potent, orally active human STING activator with an EC50 of 185 nM[1]. STING agonist-12 (Compound 53) (10 μM) shows excellent pan-polymorph activity across the panel of STING proteins (92%, 107% and 92% against R232, H232 and HAQ, respectively) in HEK293T cells[1].STING agonist-12 is not active at mouse STING[1]. STING agonist-12 (Compound 53) (5 mpk for i.v.; 10 mpk for p.o.) is well-absorbed with a short terminal half-life[1].

in vivo

STING agonist-12 (Compound 53) (5 mpk for i.v.; 10 mpk for p.o.) is well-absorbed with a short terminal half-life^[1].

Animal Model:

Balb/c mice (n=3)^[1]

Dosage:

5 or 10 mpk

Administration:

Lateral tail vein or oral gavage (Pharmacokinetic Analysis)

Result:

Pharmacokinetic profile of STING agonist-12 (Compound 53) in mouse^[1].

Route	DOSE (mpk)	AUC (ng/mL*h)	T_1/2 (h)	C_max (ng/mL)	V_d (mL/kg)	F (%)
IV	5	1215	1.41	1867	2689	NA
PO	10	2090	NA	1723	NA	86

storage

Store at -20°C

References

[1]. Pryde DC, et al. The discovery of potent small molecule activators of human STING. Eur J Med Chem. 2021 Jan 1;209:112869.

1H-Indole-6-carboxamide, 1-[(2-chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Indole-6-carboxamide, 1-[(2-chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]- Suppliers

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Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
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Wuhan Han Sheng New Material Technology Co.，Ltd	+8617798174412	admin01@hsnm.com.cn	China	2097	58
Aladdin Scientific		tp@aladdinsci.com	United States	52924	58
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Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
Wuhan Han Sheng New Material Technology Co.，Ltd	58
Aladdin Scientific	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	58
Shanghaizehan biopharma technology co., Ltd.	55
Shanghai EFE Biological Technology Co., Ltd.	58
ShangHai Biochempartner Co.,Ltd	62
Shanghai Chaolan Chemical Technology Center	58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd	58

1H-Indole-6-carboxamide, 1-[(2-chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]- STING activator Compound 53 1-(2-chloro-6-fluorobenzyl)-3,3-dimethyl-2-oxo-N-(2,4,6-trifluorobenzyl)indoline-6-carboxamide Inhibitor,HEK293T,STING agonist-12,MPYS,STING agonist12,STING,STING agonist 12,STING activator Compound 53,TMEM173,inhibit,ERIS,Stimulator of Interferon Genes,MITA C53 1-[(2-chloro-6-fluoro-phenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]indoline-6-carboxamide 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide STING agonist C53 STING activator Compound 53, 10 mM in DMSO 2259624-71-8