RO-5488608
- CAS No.
- 1337920-46-3
- Chemical Name:
- RO-5488608
- Synonyms
- RO5488608;RO 5488608;RO-5488608;[1,1'-Biphenyl]-3-sulfonic acid, 3'-[2,3-dihydro-7-methyl-2-oxo-8-(trifluoromethyl)-1H-1,5-benzodiazepin-4-yl]-
- CBNumber:
- CB011075840
- Molecular Formula:
- C23H17F3N2O4S
- Molecular Weight:
- 474.45
- MDL Number:
- MOL File:
- 1337920-46-3.mol
RO-5488608 Chemical Properties,Uses,Production
Description
RO5488608 is a new potent mGlu2/3 NAM.
Uses
RO5488608 is a negative allosteric metabotropic modulator of glutamate receptor 2/3. RO5488608 inhibits LY354740 (HY-18941)-induced intracellular Ca2+ release and can be used for study of antidepressant[1].
References
[1] Lundstr?m L, et al. Structural determinants of allosteric antagonism at metabotropic glutamate receptor 2: mechanistic studies with new potent negative allosteric modulators. Br J Pharmacol. 2011;164(2b):521-537. DOI:10.1111/j.1476-5381.2011.01409.x
RO-5488608 Preparation Products And Raw materials
Raw materials
Preparation Products
RO-5488608 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 | |
| Wuhan Han Sheng New Material Technology Co.，Ltd | +8617798174412 | admin01@hsnm.com.cn | China | 2097 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19965 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Wuhan Han Sheng New Material Technology Co.，Ltd | 58 |
| TargetMol Chemicals Inc. | 58 |