5-Bromo-thiophene-2-carboxylic acid methyl ester
- CAS No.
- 62224-19-5
- Chemical Name:
- 5-Bromo-thiophene-2-carboxylic acid methyl ester
- Synonyms
- 5-broMo-;Methyl 2-broMothiophene-5...;2-Bromo-5-(methoxycarbonyl)thiophene;Methyl 2-broMothiophene-5-carboxylate;Methyl 5-bromo-2-thiophenecarboxylate;methyl 5-bromothiophene-2-carboxylate;5-bromo-2-thiophenecarboxylic acid methyl ester;5-Bromo-thiophene-2-carboxylic acid methyl ester;2-Thiophenecarboxylic acid, 5-bromo-, methyl ester
- CBNumber:
- CB01113336
- Molecular Formula:
- C6H5BrO2S
- Molecular Weight:
- 221.07
- MDL Number:
- MFCD03233845
- MOL File:
- 62224-19-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Methyl 5-Bromothiophene-2-carboxylate min. 98.0 % | B6245 | 5G | $134 |
| Methyl 5-Bromothiophene-2-carboxylate min. 98.0 % | B6245 | 25G | $406 |
| Methyl5-Bromo-2-thiophenecarboxylate | M294170 | 1g | $85 |
| Methyl 5-bromothiophene-2-carboxylate 97.0% | 6H66-9-11 | 250mg | $90 |
| 2-Thiophenecarboxylicacid,5-bromo-,methylester >97.0% | CS-B0140 | 10g | $94 |
| More product size | |||
| Melting point | 87-88℃ |
|---|---|
| Boiling point | 251.9±20.0 °C(Predicted) |
| Density | 1.662±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| Appearance | Off-white to light brown Solid |
| InChI | InChI=1S/C6H5BrO2S/c1-9-6(8)4-2-3-5(7)10-4/h2-3H,1H3 |
| InChIKey | QLWUHAQCKDHUNL-UHFFFAOYSA-N |
| SMILES | C1(C(OC)=O)SC(Br)=CC=1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P271-P260-P280 |
| HS Code | 2932990090 |
5-Bromo-thiophene-2-carboxylic acid methyl ester price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B6245 | Methyl 5-Bromothiophene-2-carboxylate min. 98.0 % | 62224-19-5 | 5G | $134 | 2026-04-30 | Buy |
| TCI Chemical | B6245 | Methyl 5-Bromothiophene-2-carboxylate min. 98.0 % | 62224-19-5 | 25G | $406 | 2026-04-30 | Buy |
| TRC | M294170 | Methyl5-Bromo-2-thiophenecarboxylate | 62224-19-5 | 1g | $85 | 2021-12-16 | Buy |
| SynQuest Laboratories | 6H66-9-11 | Methyl 5-bromothiophene-2-carboxylate 97.0% | 62224-19-5 | 250mg | $90 | 2021-12-16 | Buy |
| ChemScene | CS-B0140 | 2-Thiophenecarboxylicacid,5-bromo-,methylester >97.0% | 62224-19-5 | 10g | $94 | 2021-12-16 | Buy |
5-Bromo-thiophene-2-carboxylic acid methyl ester Chemical Properties,Uses,Production
Uses
Methyl 5-Bromo-2-thiophenecarboxylate is used as a reagent in the synthesis of trisubstituted isoxazole derivatives which are novel nonsteroidal antagonists of Farnesoid X Receptor (FXR). FXR plays an important role in regulation of cholesterol, lipid and glucose metabolism.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 35, p. 1109, 1992 DOI: 10.1021/jm00084a016
Synthesis
67-56-1
7311-63-9
62224-19-5
General procedure for the synthesis of methyl 5-bromothiophene-2-carboxylate from methanol and 5-bromo-2-carboxythiophene: 950 mg (4.62 mmol) of 5-bromo-2-carboxythiophene was accurately weighed and dissolved in 10 mL of methanol. Under stirring conditions, 2 ml of sulfoxide chloride (SOCl2) was slowly added dropwise to the solution. After completion of the reaction, the reaction mixture was cooled to room temperature. Subsequently, the solvent was removed by evaporation under reduced pressure. The residue was dissolved in an appropriate amount of toluene and dried by evaporation under reduced pressure, this process was repeated three times to completely remove the residual sulfoxide chloride and methanol. The intermediate 5-bromothiophene-2-carboxylic acid methyl ester was finally obtained as 1.0 g in 100% yield.
References
[1] Journal of Medicinal Chemistry, 1992, vol. 35, # 6, p. 1109 - 1116
[2] Patent: CN103992311, 2017, B. Location in patent: Paragraph 0103; 0114; 0115; 0116
[3] Angewandte Chemie - International Edition, 2010, vol. 49, # 38, p. 6817 - 6820
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 22, p. 9562 - 9575
[5] Journal of Materials Chemistry A, 2013, vol. 1, # 34, p. 10008 - 10015
5-Bromo-thiophene-2-carboxylic acid methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13843 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29794 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1056@dideu.com | China | 3982 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8828 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Baoji Guokang Healthchem Co., Ltd. | +86-0917-3909592 +86-13892490616 | gksales1@gk-bio.com | China | 9080 | 58 |
View Lastest Price from 5-Bromo-thiophene-2-carboxylic acid methyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-13 | 5-Bromo-thiophene-2-carboxylic acid methyl ester
62224-19-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-10 | 5-Bromo-thiophene-2-carboxylic acid methyl ester
62224-19-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2019-12-26 | 5-Bromo-thiophene-2-carboxylic acid methyl ester
62224-19-5
|
US $1.00 / KG | 1KG | 99% | 1000KGS | Career Henan Chemical Co |
-
- 5-Bromo-thiophene-2-carboxylic acid methyl ester
62224-19-5
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 5-Bromo-thiophene-2-carboxylic acid methyl ester
62224-19-5
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 5-Bromo-thiophene-2-carboxylic acid methyl ester
62224-19-5
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
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