Dimethylammoniumdichlorotri(mu-chloro)bis[(R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]diruthenate(II)

Reaction

1. (R)-BINAP or (R)-Tol-BINAP can be combined with dichloro(1,5-cyclooctadiene)ruthenium to form precursors to NOYORI CATALYST SYSTEMS. These systems exhibit very high catalytic activity and enantioselectivity in the hydrogenation of a wide range of substrates. NOYORI CATALYST SYSTEMS have been shown to effect highly enantioselective hydrogenation of functionalized ketones where the substituents are dialkylamino, hydroxy, siloxy, carbonyl, ester, amide or thioester.
2. Useful ligand in asymmetric Heck processes.
3. Ligand employed in palladium-catalyzed asymmetric arylation of ketones.
4. Ligand employed in rhodium-catalyzed 1,4-additions to enones.
5. Ligand employed in palladium-catalyzed hydroamination of styrene derivatives.
6. Ligand employed in silver-catalyzed asymmetric Sakuri-Hosomi allylation and Mukaiyama aldol reaction.
7. Ligand employed in rhodium-catalyzed kinetic resolution of enynes.
8. Ligand employed in asymmetric rhodium-catalyzed hydroboration of cyclopropenes.
9. Ligand employed in silver-catalyzed a-hydroxylation of stannyl enol ethers.
10. Ligand employed in palladium-catalyzed synthesis of chiral allenes.
11. Ligand for palladium-catalyzed enantioselective hetero Michael addition to form b-amino acid derivatives.
12. Ligand employed in rhodium-catalyzed asymmetric rearrangement of alkynyl alkenyl carbinols.
13. Ligand employed in rhodium-catalyzed 1,2-addition of aluminium organyl compounds to cyclic enones.
14. Ligand employed in iridium-catalyzed transfer hydrogenative allylation of benzylic alcohols.
15. Ligand employed in rhodium-catalyzed asymmetric C-Si bond formation by conjugate silyl transfer using a Si-B linkage.

Uses

Takasago Ligands and Complexes for Asymmetric Reactions