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PHENACETURIC ACID

PHENACETURIC ACID structure

CAS No.: 500-98-1

Chemical Name:: PHENACETURIC ACID

Synonyms: N-PHENYLACETYLGLYCINE;PHENYLAC-GLY-OH;Phenacetylglycine;Phenylalanine metabolism;Benzylpenicillin Sodium Impurity H;AI3-23422;Phenaturic acid;PHENYLAC-GLYCINE;PHENACETURIC ACID;N-Phenacetylglycine

CBNumber:: CB0123066

Molecular Formula:: C10H11NO3

Molecular Weight:: 193.2

MDL Number:: MFCD00021744

MOL File:: 500-98-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 17:18:05

Product description	Number	Pack Size	Price
N-(2-Phenylacetyl)glycine analytical standard	96408	50 mg	$138
N-(2-Phenylacetyl)glycine analytical standard	96408	250 mg	$280
Phenaceturic Acid >98.0%(HPLC)(T)	P0131	25g	$67
Phenylacetylglycine ≥98%	36368	25mg	$33
Phenylacetylglycine ≥98%	36368	50mg	$55

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PHENACETURIC ACID Properties

Melting point	144°C
Boiling point	476.5±38.0 °C(Predicted)
Density	1.239±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Methanol (Slightly)
form	Solid
pka	3.48±0.10(Predicted)
color	White to Off-White
Major Application	clinical testing
InChI	InChI=1S/C10H11NO3/c12-9(11-7-10(13)14)6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H,11,12)(H,13,14)
InChIKey	UTYVDVLMYQPLQB-UHFFFAOYSA-N
SMILES	C(O)(=O)CNC(CC1=CC=CC=C1)=O
CAS DataBase Reference	500-98-1
FDA UNII	O134PDX2SP
UNSPSC Code	12352209
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Safety Statements	24/25
WGK Germany	WGK 3
HazardClass	IRRITANT
HS Code	2924297099
Storage Class	11 - Combustible Solids
Hazard Classifications	Eye Irrit. 2

PHENACETURIC ACID price More Price(59)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	96408	N-(2-Phenylacetyl)glycine analytical standard	500-98-1	50 mg	$138	2026-04-30	Buy
Sigma-Aldrich	96408	N-(2-Phenylacetyl)glycine analytical standard	500-98-1	250 mg	$280	2026-04-30	Buy
TCI Chemical	P0131	Phenaceturic Acid >98.0%(HPLC)(T)	500-98-1	25g	$67	2026-04-30	Buy
Cayman Chemical	36368	Phenylacetylglycine ≥98%	500-98-1	25mg	$33	2026-04-30	Buy
Cayman Chemical	36368	Phenylacetylglycine ≥98%	500-98-1	50mg	$55	2026-04-30	Buy

Product number	Packaging	Price	Buy
96408	50 mg	$138	Buy
96408	250 mg	$280	Buy
P0131	25g	$67	Buy
36368	25mg	$33	Buy
36368	50mg	$55	Buy

PHENACETURIC ACID Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

A metabolite of carboxylic acid.

Definition

ChEBI: A N-acylglycine that is glycine substituted on nitrogen with a phenylacetyl group.

Biological Activity

Phenylacetylglycine is an acylglycine. Acylglycines are normally minor metabolites of fatty acids. However, the excretion of certain acylglycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acylglycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme th at catalyzes the chemical reaction: acyl-CoA + glycine ↔ CoA + N-acylglycine. Phenylacetylglycine or PAG is a glycine conjugate of phenylacetic acid. Phenylacetic acid may arise from exposure to styrene (plastic) or through the consumption of fruits and vegetables. Phenylacetic acid is used in some perfumes, possessing a honey-like odour in low concentrations, and is also used in penicillin G production. PAG is a putative biomarker of phospholipidosis. Urinary PAG is elevated in animals exhibiting abnormal phospholipid accumulation in many tissues and may thus be useful as a surrogate biomarker for phospholipidosis. The presence of phenylacetylglycine in urine has been confirmed for dogs, rats and mice. However, the presence of this compound in human urine is controversial. GC-MS studies have not found this compound while NMR studies claimed to have identified it , It appears th at phenylacetylglycine may sometimes be mistaken for phenylacetylglutamine via NMR.

Synthesis

56-40-6

103-80-0

500-98-1

Glycine (100 mg, 1.33 mmol) was dissolved in 2 M aqueous sodium hydroxide solution (2 mL) followed by the addition of acetone (2 mL) and the reaction mixture was cooled in an ice bath. Phenylacetyl chloride (161 μL, 1.21 mmol) was slowly added dropwise while maintaining the same temperature. After the dropwise addition, the reaction system was gradually warmed up to room temperature and stirred continuously for 6 hours. Upon completion of the reaction, the solvent was removed by rotary evaporator and the residue was adjusted to pH 2-3 with 1 M hydrochloric acid solution and subsequently extracted with ethyl acetate. The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated to give phenylacetylglycine (190 mg, 81% yield) as a white solid. The product was characterized by 1H NMR (300 MHz, acetone-d6): δ= 7.41-7.20 (m, 5H), 3.95 (d, J = 5.74 Hz, 1H), 3.59 (s, 2H).13C NMR (75 MHz, DMSO-d6): δ= 171.53, 170.81, 136.32, 129.25, 128.36, 126.55, 42.15, 40.95. MALDI-TOF-MS analysis: calculated value of 194.1 and measured value of 194.1 [M + H]+ for C10H12NO3.

IC 50

β2 adrenoceptor; Microbial Metabolite; Human Endogenous Metabolite

References

[1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 11, p. 3465 - 3469
[2] Journal fuer Praktische Chemie (Leipzig), 1888, vol. <2> 38, p. 102
[3] Journal of Biological Chemistry, 1920, vol. 43, p. 468
[4] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 15, p. 3966 - 3970
[5] Oriental Journal of Chemistry, 2010, vol. 26, # 4, p. 1533 - 1536

PHENACETURIC ACID Preparation Products And Raw materials

Raw materials

Glycine Phenylacetyl chloride Hydrochloric acid Sodium hydroxide

Preparation Products

PHENACETURIC ACID Suppliers

Global( 195)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Guangzhou PI PI BIOTECH INC	+86-86-020-81716320 +8613602409664	Sales@pipitech.com	China	973	55
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	10000	58
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19853	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52705	58
Bio Connect Life Sciences		info@bio-connect.nl	United States	261	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19908	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39039	58
GIHI CHEMICALS CO.,LIMITED	+86-571-86217390; +8618058761490	info@gihichemicals.com	China	49967	58

Supplier	Advantage
Guangzhou PI PI BIOTECH INC	55
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Shaanxi Dideu Medichem Co. Ltd	58
BOC Sciences	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Bio Connect Life Sciences	58
Nextpeptide Inc	58
TargetMol Chemicals Inc.	58
GIHI CHEMICALS CO.,LIMITED	58

View Lastest Price from PHENACETURIC ACID manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-22	2-(2-Phenylacetamido)acetic acid 500-98-1	$29.00		99.59%	10g	TargetMol Chemicals Inc.
2022-02-19	Phenaceturic acid 500-98-1		1KG	98.7%	100 tons	Honest Joy Holdings Limited
2021-07-02	Phenaceturic Acid 500-98-1	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd

2-(2-Phenylacetamido)acetic acid
500-98-1
$29.00
99.59%
TargetMol Chemicals Inc.

Phenaceturic acid
500-98-1
$0.00
98.7%
Honest Joy Holdings Limited

Phenaceturic Acid
500-98-1
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

PHENACETURIC ACID Spectrum

PHENACETURIC ACID(500-98-1)MS PHENACETURIC ACID(500-98-1)¹HNMR PHENACETURIC ACID(500-98-1)IR1 PHENACETURIC ACID(500-98-1)IR2 PHENACETURIC ACID(500-98-1)Raman

500-98-1(PHENACETURIC ACID)Related Search:

H-D-PHG-OME HCL Dihydrophenylglycine methyl Deng sodium salt penilloic acid 5-benzyl-2,2-dimethyl-2,3,7,7a-tetrahydroimidazo[5,1-b][1,3]thiazole-3,7-dicarboxylic acid Penicillin V potassium salt

Penicillin G Benzathine PENICILLIC ACID Methylaminoacetaldehyde dimethyl acetal 1,1-Dimethoxy-N,N-dimethylethylamine 1,1,2-Trimethoxyethane

1,1-Dimethoxy-2-(2-methoxyethoxy)ethane

1of3

PHENACETURIC ACID PHENYLACETYL GLYCINE PHENYLAC-GLYCINE PHENYLAC-GLY-OH N-ALPHA-PHENYLACETYL-GLYCINE 2-(2-phenylacetyl)aminoacetic acid Phenaturic acid Benzylpenicillin CP Impurity H N-(2-Phenylacetyl)glycine Benzylpenicillin Sodium Impurity Ⅵ:Impurity H)2-(2-PhenylacetaMido)acetic acid Benzylpenicillin Sodium Impurity H(CP) 2-(2-PhenylacetaMido)acetic acid 2-(2-phenylethanoylamino)ethanoic acid 2-[(1-oxo-2-phenylethyl)amino]acetic acid AI3-23422 Glycine, N-(phenylacetyl)- N-Phenacetylglycine Phenylalanine metabolism 2-(2-Phenylacetamido) Phenylacetyl glycine≥ 99% (HPLC) Benzylpenicillin Impurity H Penicillin CP Impurity H PhenaceturicAcid> Glycine, N-(2-phenylacetyl)- PHENACETURIC ACID USP/EP/BP Benzylpenicillin Sodium Impurity H Benzylpenicillin sodium CP Impurity H Phenoxymethylpenicillin CP?Impurity H Benzylpenicillin Impurity 8(Benzylpenicillin CP Impurity H) Penicillin ChP Impurity H Penicillin sodium impurity H Benzylpenicillin Impurity 27 Phenaceturic acid|||Phenyl-ac-Gly-OH|||Phenylacetyl glycine Penicillin G Potassium Impurity G 2-(2-Phenylacetamido)acetic acid, 10 mM in DMSO N-(2-Phenylacetyl)glycine PHENYLACETYL-GLYCINE (PAA-Gly) 2-(2-Phenyl-acetcarboxcarboxcarboxamido)-acetic acid Benzylpenicillin Sodium Impurity Ⅵ:Impurity H)2-(2-PhenylacetaMido)acetic acid Penicillin Impurity H(CP) 2-(2-Phenylacetamido)acetic acid (Benzylpenicillin Impurity) N-PHENYLACETYLGLYCINE Phenacetylglycine 500-98-1 ARYL AMIDE Metabolites & Impurities Amino Acids & Derivatives Aromatics