1H-Pyrazole-1-carboxylicacid,3-amino-5-methyl-,1,1-dimethylethylester
- CAS No.
- 578008-32-9
- Chemical Name:
- 1H-Pyrazole-1-carboxylicacid,3-amino-5-methyl-,1,1-dimethylethylester
- Synonyms
- tert-butyl 3-aMino-5-Methyl-1H-pyrazole-1-carboxylate;1-Boc-3-Amino-5-methylpyrazole;3-Amino-1-Boc-5-methyl-1H-pyrazole;1-BOC-3-amino-5-methyl-1H-pyrazole;tert-butyl 3-amino-5-methyl-pyrazole-1-carboxylate;tert-Butyl 3-amino-5-methyl-1H-pyrazol-1-carboxylate;3-Amino-5-methylpyrazole-1-carboxylic acid tert-butyl ester;tert-butyl 3-amino-5-methyl-pyrazole-1-carboxylate - [B87012];1H-Pyrazole-1-carboxylicacid,3-amino-5-methyl-,1,1-dimethylethylester;1h-Pyrazole-1-Carboxylic Acid, 3-Amino-5-Methyl-, 1,1-Dimethylethyl Este
- CBNumber:
- CB01281817
- Molecular Formula:
- C9H15N3O2
- Molecular Weight:
- 197.23
- MDL Number:
- MFCD13252375
- MOL File:
- 578008-32-9.mol
| Boiling point | 322.7±34.0 °C(Predicted) |
|---|---|
| Density | 1.18±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C, protect from light |
| pka | 2.89±0.11(Predicted) |
| Appearance | White to yellow Solid |
| InChI | InChI=1S/C9H15N3O2/c1-6-5-7(10)11-12(6)8(13)14-9(2,3)4/h5H,1-4H3,(H2,10,11) |
| InChIKey | GJDCNROAKOCYIQ-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)C(C)=CC(N)=N1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
1H-Pyrazole-1-carboxylicacid,3-amino-5-methyl-,1,1-dimethylethylester price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | DYA00832 | tert-Butyl 3-amino-5-methyl-1H-pyrazole-1-carboxylate | 578008-32-9 | 5g | $584.1 | 2026-06-04 | Buy |
| Biosynth | DYA00832 | tert-Butyl 3-amino-5-methyl-1H-pyrazole-1-carboxylate | 578008-32-9 | 10g | $778.8 | 2026-06-04 | Buy |
| Biosynth | DYA00832 | tert-Butyl 3-amino-5-methyl-1H-pyrazole-1-carboxylate | 578008-32-9 | 25g | $1168.25 | 2026-06-04 | Buy |
| Synthonix | B87012 | tert-butyl 3-amino-5-methyl-pyrazole-1-carboxylate 97% | 578008-32-9 | 1g | $40 | 2026-05-06 | Buy |
| Synthonix | B87012 | tert-butyl 3-amino-5-methyl-pyrazole-1-carboxylate 97% | 578008-32-9 | 5g | $170 | 2026-05-06 | Buy |
1H-Pyrazole-1-carboxylicacid,3-amino-5-methyl-,1,1-dimethylethylester Chemical Properties, Uses, Production
Synthesis
31230-17-8
24424-99-5
1065204-79-6
578008-32-9
GENERAL STEPS: 3-Amino-5-methyl-1H-pyrazole (2.0 g, 20.6 mmol) was dissolved in THF (40 ml) and cooled to 0 °C. NaH (95%, 0.57 g, 22.7 mmol) was added slowly with stirring. after 30 min, di-tert-butyl dicarbonate (Boc2O, 4.94 g, 22.7 mmol) was added and then the mixture was gradually warmed up to room temperature. The reaction mixture continued to be stirred at room temperature for 2 hours. After completion of the reaction, the mixture was poured into saturated aqueous NaHCO3 solution. The aqueous phase was extracted with CHCl3, the organic phases were combined and dried over Na2SO4. The solvent was removed by concentration under reduced pressure to give a crude mixture of 1-Boc-3-amino-5-methylpyrazole and its tert-butyl 2-carboxylate isomer. The separation and purification was carried out by silica gel column chromatography using ethyl acetate/heptane (2:1) as eluent. The target products 5-amino-3-methyl-1H-pyrazole-1-carboxylic acid tert-butyl ester and 1-Boc-3-amino-5-methylpyrazole were obtained in a yield of 2.4 g and 59%.1H-NMR (400 MHz, D6-DMSO): δ 5.60 (1H, s), 5.27 (2H, s), 2.34 (3H, s), 1.51 (9H, s); MS (ESI+): m/z = 198.26 ([M-H]+).
References
[1] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 9, p. 2114 - 2124
[2] Patent: WO2006/32518, 2006, A1. Location in patent: Page/Page column 200
[3] Patent: WO2012/30944, 2012, A2. Location in patent: Page/Page column 81-82
[4] Nucleosides, Nucleotides and Nucleic Acids, 2014, vol. 33, # 8, p. 552 - 582
1H-Pyrazole-1-carboxylicacid,3-amino-5-methyl-,1,1-dimethylethylester Preparation Products And Raw materials
Raw materials
Preparation Products
1H-Pyrazole-1-carboxylicacid,3-amino-5-methyl-,1,1-dimethylethylester Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Cool Pharm, Ltd | 021-58581007 18019463053 | sales@coolpharm.com | China | 9999 | 58 |
| Jiaxing Hengrui Biotechnology Co. LTD | 0573-0573-82672231 13757365595 | regen_chemical1@163.com | China | 4858 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9513 | 58 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| Record Tech (Shanghai) Co., LTD | 13761627472 | 183009664@qq.com | China | 660 | 62 |
| Anhui Shite Pharmaceutical Technology Co., LTD | 086-21-50829787 13621628489 | sales1@stepuppharm.com | China | 253 | 55 |
| AstaTech (Chengdu) Pharma. Co., Ltd. | 15928766785 15928766785 | wupengcheng@astatech.cn | China | 1995 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai ChuangYan Chemical Technology Co., Ltd. | 021-11111111 11111111111 | 546919421@qq.com | China | 3770 | 55 |
View Latest Price from 1H-Pyrazole-1-carboxylicacid,3-amino-5-methyl-,1,1-dimethylethylester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-07-20 | tert-butyl3-amino-5-methyl-pyrazole-1-carboxylate
578008-32-9
|
1KG | 98% | 1000kgs | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2020-01-10 | 1H-Pyrazole-1-carboxylicacid,3-amino-5-methyl-,1,1-dimethylethylester
578008-32-9
|
$6.00 | 1KG | 98% | 1kg, 5kg, 50kg | Career Henan Chemical Co |
-
- tert-butyl3-amino-5-methyl-pyrazole-1-carboxylate
578008-32-9
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 1H-Pyrazole-1-carboxylicacid,3-amino-5-methyl-,1,1-dimethylethylester
578008-32-9
- $6.00
- 98%
- Career Henan Chemical Co
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