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ChemicalBook >> CAS DataBase List >>3-Oxabicyclo[3.1.0]hexane-6-carboxylicacid,ethylester(9CI)

3-Oxabicyclo[3.1.0]hexane-6-carboxylicacid,ethylester(9CI)

3-Oxabicyclo[3.1.0]hexane-6-carboxylicacid,ethylester(9CI) Structure
3-Oxabicyclo[3.1.0]hexane-6-carboxylicacid,ethylester(9CI) structure
CAS No.
335599-07-0
Chemical Name:
3-Oxabicyclo[3.1.0]hexane-6-carboxylicacid,ethylester(9CI)
Synonyms
Ethyl 3-oxa-bicyclo[3.1.0]hexane-6-carboxylate;ethyl (exo)-3-oxabicyclo[3.1.0]hexane-6-carboxylate;3-Oxabicyclo<3.1.0>hexan-exo-6-carbonsaeure-ethylester;3-Oxabicyclo[3.1.0]hexane-6-carboxylic acid, ethyl ester;3-Oxabicyclo[3.1.0]hexane-6-carboxylicacid,ethylester(9CI)
CBNumber:
CB01295984
Molecular Formula:
C8H12O3
Molecular Weight:
156.18
MDL Number:
MFCD01606212
MOL File:
335599-07-0.mol
MSDS File:
SDS
Last updated:2026-05-27 22:29:35
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3-Oxabicyclo[3.1.0]hexane-6-carboxylicacid,ethylester(9CI) Properties

storage temp. Sealed in dry,Room Temperature
Appearance Colorless to light yellow Liquid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  warning
Hazard statements  H302-H313-H315-H319-H335
Precautionary statements  P264-P270-P301+P312-P330-P501-P312-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P403+P233-P405

3-Oxabicyclo[3.1.0]hexane-6-carboxylicacid,ethylester(9CI) price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
aablocks AA00CLVV Ethyl 3-Oxa-Bicyclo[3.1.0]Hexane-6-Carboxylate 95% 335599-07-0 100mg $216 2026-05-28 Buy
aablocks AA00CLVV Ethyl 3-Oxa-Bicyclo[3.1.0]Hexane-6-Carboxylate 95% 335599-07-0 250mg $278 2026-05-28 Buy
ACHEMBLOCK F-4897 Ethyl 3-oxa-bicyclo[3.1.0]hexane-6-carboxylate 95% 335599-07-0 250MG $165 2026-05-27 Buy
ACHEMBLOCK F-4897 Ethyl 3-oxa-bicyclo[3.1.0]hexane-6-carboxylate 95% 335599-07-0 1G $435 2026-05-27 Buy
ACHEMBLOCK F-4897 Ethyl 3-oxa-bicyclo[3.1.0]hexane-6-carboxylate 95% 335599-07-0 5G $1610 2026-05-27 Buy
Product number Packaging Price Buy
AA00CLVV 100mg $216 Buy
AA00CLVV 250mg $278 Buy
F-4897 250MG $165 Buy
F-4897 1G $435 Buy
F-4897 5G $1610 Buy

3-Oxabicyclo[3.1.0]hexane-6-carboxylicacid,ethylester(9CI) Chemical Properties, Uses, Production

Synthesis

2,5-Dihydrofuran

1708-29-8

Ethyl diazoacetate

623-73-4

3-Oxabicyclo[3.1.0]hexane-6-carboxylicacid,ethylester(9CI)

335599-07-0

The suspension was heated and stirred at 90-100 °C with 2,5-dihydrofuran (14 g, 200 mmol) and Cu(II)(acac)2 (1.05 g, 4 mmol). Subsequently, a benzene (PhH, 240 mL) solution of ethyl azidoacetate (27.3 g, 240 mmol) was slowly added dropwise to the reaction system over a period of 3 hours. After completion of the dropwise addition, the reaction mixture was cooled to room temperature and the solvent was removed by evaporation. The residue was dissolved in petroleum ether and purified by adsorption through a neutral alumina column (240 g of alumina per 10 mmol of diazoxide), eluting sequentially with 500 mL of petroleum ether and 500 mL of ether (Et2O). Removal of the solvent from the eluent gave the crude product ester, which was subjected to reduced pressure distillation at about 105°C (18-19 mmHg). The fractions were further purified by silica gel (SiO2) column chromatography using gradient elution with ethyl acetate (EtOAc)/hexane (0 to 30% EtOAc), resulting in 15.39 g (45.8% yield) of ethyl 3-oxo-bicyclo[3.1.0]hexane-6-carboxylate as the target product (Ref: I. Reichelt and H. J. Reissig , Chem. Ber. 1983, 116, 3895).

References

[1] Patent: US2008/249087, 2008, A1. Location in patent: Page/Page column 26-27

3-Oxabicyclo[3.1.0]hexane-6-carboxylicacid,ethylester(9CI) Preparation Products And Raw materials

Raw materials

2,5-Dihydrofuran Ethyl diazoacetate

Preparation Products

3-Oxabicyclo[3.1.0]hexane-6-carboxylicacid,ethylester(9CI) Suppliers

Global Suppliers ( 29)
Supplier Tel Email Country ProdList Advantage
Shanghai Xiannuo Biotechnology Co., Ltd. 021-50718719 13918719472 China 978 58
SynAsst Chemical. 021-60343070 China 12731 55
Shanghai Raise Chemical Technology Co.,Ltd 15026594951 rs@raise-chem.com China 4904 55
Shanghai KunRaise Chemical Technology Co., Ltd +86-021-50935922 China 715 55
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Aikon International Limited 025-58859352 19370895928 sales01@aikonchem.com China 15078 58
Nanjing SynTitan Pharmaceutical Co., Ltd. 025-57027686 17372956142 li_lan@syntitan.com China 9999 58
Hangzhou Huarong Pharm Co., Ltd. 571-86758373 +8613588754946 sales@huarongpharm.com CHINA 3147 58
Xi'an Minze Pharmaceutical Technology Co., Ltd 13981836672 2560370848@qq.com China 2807 58
Zhejiang Lianshuo Biotechnology Co., Ltd. 18616526224 lianshuo@vip.126.com China 9605 58
Supplier Advantage
Shanghai Xiannuo Biotechnology Co., Ltd. 58
SynAsst Chemical. 55
Shanghai Raise Chemical Technology Co.,Ltd 55
Shanghai KunRaise Chemical Technology Co., Ltd 55
Amadis Chemical Company Limited 58
Aikon International Limited 58
Nanjing SynTitan Pharmaceutical Co., Ltd. 58
Hangzhou Huarong Pharm Co., Ltd. 58
Xi'an Minze Pharmaceutical Technology Co., Ltd 58
Zhejiang Lianshuo Biotechnology Co., Ltd. 58

3-Oxabicyclo[3.1.0]hexane-6-carboxylicacid,ethylester(9CI) Spectrum

3-Oxabicyclo[3.1.0]hexane-6-carboxylicacid,ethylester(9CI)(335599-07-0)1HNMR

335599-07-0 (3-Oxabicyclo[3.1.0]hexane-6-carboxylicacid,ethylester(9CI)) Related Search:

ethyl trans-3-oxabicyclo[3.1.0]hexane-6-carboxylate trans-3-oxabicyclo[3.1.0]hexane-6-carboxylic acid (1R,5S,6s)-3-Oxabicyclo[3.1.0]hexane-6-carboxylic acid (1R,5S,6S)-Ethyl 3-oxabicyclo[3.1.0]hexane-6-carboxylate 3-Oxabicyclo[3.1.0]hexane-6-carboxylic acid
trans-3-Oxabicyclo[3.1.0]hexane-6-Methanol

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3-Oxabicyclo[3.1.0]hexane-6-carboxylicacid,ethylester(9CI) 3-Oxabicyclo<3.1.0>hexan-exo-6-carbonsaeure-ethylester Ethyl 3-oxa-bicyclo[3.1.0]hexane-6-carboxylate 3-Oxabicyclo[3.1.0]hexane-6-carboxylic acid, ethyl ester ethyl (exo)-3-oxabicyclo[3.1.0]hexane-6-carboxylate 335599-07-0 CARBOXYLICESTER