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rhapontigenin

rhapontigenin structure

CAS No.: 500-65-2

Chemical Name:: rhapontigenin

Synonyms: Protigenin;rhapontigenin;3-benzenediol;Rhapontigenin-RM;Rhapontigenin >rhapontigenin USP/EP/BP;Rhapontigenin (Standard);-5-(3-Hydroxy-4-methoxystyryl);COc2ccc(/C=C/c1cc(O)cc(O)c1)cc2O;(E)-4'-Methoxy-3,3',5-stilbenetriol

CBNumber:: CB01309681

Molecular Formula:: C15H14O4

Molecular Weight:: 258.27

MDL Number:: MFCD00017718

MOL File:: 500-65-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-14 16:49:18

Product description	Number	Pack Size	Price
Rhapontigenin >98.0%(GC)	R0089	100mg	$216
Rhapontigenin ≥98%	13293	1mg	$61
Rhapontigenin ≥98%	13293	5mg	$137
Rhapontigenin ≥98%	13293	10mg	$242
Rhapontigenin ≥98%	13293	25mg	$379
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rhapontigenin Properties

Melting point	189.0 to 193.0 °C
Boiling point	503.6±38.0 °C(Predicted)
Density	1.345±0.06 g/cm3(Predicted)
storage temp.	4°C, protect from light
solubility	≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
form	powder to crystal
pka	9.17±0.10(Predicted)
color	White to Light yellow
Major Application	food and beverages
InChI	InChI=1S/C15H14O4/c1-19-15-5-4-10(8-14(15)18)2-3-11-6-12(16)9-13(17)7-11/h2-9,16-18H,1H3/b3-2+
InChIKey	PHMHDRYYFAYWEG-NSCUHMNNSA-N
SMILES	C1(O)=CC(/C=C/C2=CC=C(OC)C(O)=C2)=CC(O)=C1
CAS DataBase Reference	500-65-2
FDA UNII	22BG4NNH6W
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

WGK Germany	WGK 3
HS Code	2914.50.3000
Storage Class	11 - Combustible Solids

rhapontigenin price More Price(77)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	R0089	Rhapontigenin >98.0%(GC)	500-65-2	100mg	$216	2026-04-30	Buy
Cayman Chemical	13293	Rhapontigenin ≥98%	500-65-2	1mg	$61	2026-04-30	Buy
Cayman Chemical	13293	Rhapontigenin ≥98%	500-65-2	5mg	$137	2026-04-30	Buy
Cayman Chemical	13293	Rhapontigenin ≥98%	500-65-2	10mg	$242	2026-04-30	Buy
Cayman Chemical	13293	Rhapontigenin ≥98%	500-65-2	25mg	$379	2026-04-30	Buy

Product number	Packaging	Price	Buy
R0089	100mg	$216	Buy
13293	1mg	$61	Buy
13293	5mg	$137	Buy
13293	10mg	$242	Buy
13293	25mg	$379	Buy

rhapontigenin Chemical Properties,Uses,Production

Description

Rhapontigenin is a natural analog of resveratrol and an inhibitor of CYP1A1.

Description

Rhapontigenin is a natural analog of resveratrol with antioxidant and anti-cancer activity. It is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC₅₀ = 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens. At higher concentrations, rhapontigenin inhibits the proliferation of HepG2 and HL-60R cancer cell lines (IC₅₀ = 48 μM).

Chemical Properties

Yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from Rheum officinale.

Uses

Rhapontigenin is a natural analog of resveratrol with antioxidant and anti-cancer activity. It is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50 = 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens. At higher concentrations, rhapontigenin inhibits the proliferation of HepG2 and HL-60R cancer cell lines (IC50 = 48 μM).[Cayman Chemical]

Uses

Rhapontigenin is a natural analog of resveratrol and an inhibitor of CYP1A1.

Definition

ChEBI: Rhapontigenin is a stilbenoid.

in vivo

Rhapontigenin (intraperitoneal injection; 25mg/kg) shows significant protection from death due to pulmonary thrombosis in mice, those samples are orally administered 90 min before tail vein injection of epinephrine and collagen^[3].

Animal Model:	ICR mice^[3]
Dosage:	25mg/kg
Administration:	25mg/kg; intraperitoneal injection
Result:	Showed anti-thrombosis activity with 60% protection.

IC 50

CYP1A1: 400 nM (IC₅₀)

References

[1]. chun yj, ryu sy, jeong tc, et al. mechanism-based inhibition of human cytochrome p450 1a1 by rhapontigenin. drug metab dispos. 2001 apr;29(4 pt 1):389-93.
[2]. roberti m1, pizzirani d, simoni d, et al. synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents. j med chem. 2003 jul 31;46(16):3546-54.
[3]. roupe ka1, helms gl, halls sc, et al. preparative enzymatic synthesis and hplc analysis of rhapontigenin: applications to metabolism, pharmacokinetics and anti-cancer studies. j pharm pharm sci. 2005 aug 22;8(3):374-86.

rhapontigenin Preparation Products And Raw materials

Raw materials

Preparation Products

rhapontigenin Suppliers

Global( 209)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BINBO BIOLOGICAL CO.,LTD	+8618629063126	info@binbobiological.com	China	480	58
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3619	58
Chengdu Greenpure Biopharma CO.,Ltd	18283602253; +8618283602253	jancyzheng@gcgreenpure.com	China	954	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29812	58
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2994	58
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	scglp@glp-china.com	CHINA	1824	58
Chengdu Biopurify Phytochemicals Ltd.	+86-28-82633860; +8618080483897	sales@biopurify.com	China	4616	58
Shanghai Standard Technology Co., Ltd.	18502101150	ft-sales@nature-standard.com	CHINA	1923	58
Wuhan ChemNorm Biotech Co.,Ltd.	+86-27-8439 4403 18971486879	sales@chemnorm.com	CHINA	2935	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58

Supplier	Advantage
BINBO BIOLOGICAL CO.,LTD	58
Shanghai Zheyan Biotech Co., Ltd.	58
Chengdu Greenpure Biopharma CO.,Ltd	58
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Chengdu GLP biotechnology Co Ltd	58
Chengdu Biopurify Phytochemicals Ltd.	58
Shanghai Standard Technology Co., Ltd.	58
Wuhan ChemNorm Biotech Co.,Ltd.	58
TargetMol Chemicals Inc.	58

View Lastest Price from rhapontigenin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-14	Rhapontigenin 500-65-2	$51.00-184.00		99.72%	10g	TargetMol Chemicals Inc.
2026-05-22	Rhapontigenin 500-65-2		1kg	>98%	1000 kg	BINBO BIOLOGICAL CO.,LTD
2024-03-28	Rhapontigenin 500-65-2		25kg	98%		PNP Biotech Co. Ltd

Rhapontigenin
500-65-2
$51.00-184.00
99.72%
TargetMol Chemicals Inc.

Rhapontigenin
500-65-2
$0.00
>98%
BINBO BIOLOGICAL CO.,LTD

Rhapontigenin
500-65-2
$0.00
98%
PNP Biotech Co. Ltd

rhapontigenin Spectrum

rhapontigenin(500-65-2)¹HNMR

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1of4

3-benzenediol 5-[(1E)-2-(3-hydroxy-4-methoxyphenyl)ethenyl]-1 5-[(1E)-2-(3-HYDROXY-4-METHOXYPHENYL)ETHENYL]-1;3-BENZENEDIOL 5-[2-(3-hydroxy-4-methoxyphenyl)ethenyl]benzene-1,3-diol rhapontigenin (E)-5-[2-(3-Hydroxy-4-methoxyphenyl)ethenyl]-1,3-benzenediol 3,3',5-Trihydroxy-4'-methoxy-trans-stilbene trans-1-(3,5-Dihydroxyphenyl)-2-(3-hydroxy-4-methoxyphenyl)ethylene (E)-4'-Methoxy-3,3',5-stilbenetriol (E)-5-(3-Hydroxy-4-Methoxystyryl)benzene-1,3-diol -5-(3-Hydroxy-4-methoxystyryl) Rhapontigenin > Protigenin 1,3-Benzenediol,5-[(1E)-2-(3-hydroxy-4-methoxyphenyl)ethenyl]- 3,3',5-Trihydroxy-4'-methoxy-trans-stilbene trans-1-(3,5-Dihydroxyphenyl)-2-(3-hydroxy-4-methoxyphenyl)ethylene rhapontigenin USP/EP/BP COc2ccc(/C=C/c1cc(O)cc(O)c1)cc2O Rhapontigenin-RM Rhapontigenin (Standard) 500-65-2