4-Chloro-2-hydroxybenzaldehyde
- CAS No.
- 2420-26-0
- Chemical Name:
- 4-Chloro-2-hydroxybenzaldehyde
- Synonyms
- 4-Chlorosalicylaldehy;4-chlorosalicylaldehyde;4-Chlorosalicylaldehyde >4-chloro-2-hydoxybenzaldehye;4-chloro-2-hydoxybenzaldehyde;2-hydroxy-4-chlorobenzaldehyde;4-CHLORO-2-HYDROXY-BENZALDEHYDE;Benzaldehyde, 4-chloro-2-hydroxy-;4-Chloro-2-hydroxybenzaldehyde 98%;4-Chloro-2-hydroxy-benzaldehyde ,97%
- CBNumber:
- CB0132552
- Molecular Formula:
- C7H5ClO2
- Molecular Weight:
- 156.57
- MDL Number:
- MFCD06252499
- MOL File:
- 2420-26-0.mol
- MSDS File:
- SDS
| Melting point | 45.0 to 49.0 °C |
|---|---|
| Boiling point | 229.1±20.0 °C(Predicted) |
| Density | 1.404±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Sparingly), Methanol (Slightly) |
| form | Solid |
| pka | 7.21±0.10(Predicted) |
| color | Off-White to Pale Brown |
| InChI | InChI=1S/C7H5ClO2/c8-6-2-1-5(4-9)7(10)3-6/h1-4,10H |
| InChIKey | QNZWAJZEJAOVPN-UHFFFAOYSA-N |
| SMILES | C(=O)C1=CC=C(Cl)C=C1O |
| CAS DataBase Reference | 2420-26-0 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| HS Code | 2913000090 | |||||||||
| NFPA 704 |
|
4-Chloro-2-hydroxybenzaldehyde price More Price(70)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C2653 | 4-Chlorosalicylaldehyde >95.0%(GC)(T) | 2420-26-0 | 1g | $88 | 2026-04-30 | Buy |
| TCI Chemical | C2653 | 4-Chlorosalicylaldehyde >95.0%(GC)(T) | 2420-26-0 | 5g | $350 | 2026-04-30 | Buy |
| Usbiological | 431510 | 4-Chloro-2-hydroxybenzaldehyde | 2420-26-0 | 250mg | $319 | 2026-06-03 | Buy |
| Usbiological | 431510 | 4-Chloro-2-hydroxybenzaldehyde | 2420-26-0 | 500mg | $453 | 2026-06-03 | Buy |
| Usbiological | 267602 | 4-Chloro-2-hydroxybenzaldehyde Asreported | 2420-26-0 | 100mg | $337 | 2026-06-03 | Buy |
4-Chloro-2-hydroxybenzaldehyde Chemical Properties, Uses, Production
Uses
4-Chloro-2-hydroxybenzaldehyde is an intermediate used to prepare benzodiazepine diones as Hdm2 antagonists. It is also used to synthesize hydroxy-dimethyl-oxo-cyclohexenyl-dimethyl-tetrahydro-xanthenone as oral neuropeptide Y5 receptor antagonist.
Synthesis
50-00-0
108-43-0
2420-26-0
To a 1L three-necked round-bottomed flask was added 3-chlorophenol (33.6 g, 0.3 mol), anhydrous MgCl2 (85.7 g, 0.9 mmol), triethylamine (75.9 g, 0.75 mol) and anhydrous acetone (340 mL). The resulting solution was stirred at 25 °C for 30 min, followed by the addition of paraformaldehyde (45 g, 1.5 mol). The reaction mixture was heated to reflux for 5 h under nitrogen protection. When TLC monitoring showed complete consumption of the feedstock, the acetone was evaporated under reduced pressure. The residue was acidified to pH 3 with 10% hydrochloric acid solution and extracted with ethyl acetate (3 x 150 mL). The organic layers were combined, washed with water, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give a brownish-red oil (18.1 g, 43.1% yield), which can be used directly in subsequent reactions without further purification (Byun et al., 2008; Uini and Lars, 1999).
References
[1] Applied Organometallic Chemistry, 2018, vol. 32, # 2,
[2] Drug Metabolism and Disposition, 2017, vol. 45, # 12, p. 1354 - 1363
[3] Organic and Biomolecular Chemistry, 2017, vol. 15, # 6, p. 1530 - 1536
[4] Organic Letters, 2015, vol. 17, # 23, p. 5824 - 5827
[5] Organic and Biomolecular Chemistry, 2016, vol. 14, # 30, p. 7268 - 7274
4-Chloro-2-hydroxybenzaldehyde Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Carman Chemical Co., ltd | 0519-0519-83534936 18151214939 | 1521178147@qq.com | China | 501 | 58 |
| Changzhou Jiezhan Chemical Technology Co., Ltd | 15861130028 | 956912955@qq.com | China | 300 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
View Latest Price from 4-Chloro-2-hydroxybenzaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 4-Chloro-2-hydroxybenzaldehyde
2420-26-0
|
20kg | 99% | 20 tons | Qingdao RENAS Polymer Material Co., Ltd. | ||
 |
2026-03-20 | 4-Chloro-2-hydroxybenzaldehyde
2420-26-0
|
$1.00 | 1kg | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-05-26 | 4-Chloro-2-hydroxybenzaldehyde
2420-26-0
|
$5.00 | 1kg | 0.99 | 10000 | Hebei Fengjia New Material Co., Ltd |
-
- 4-Chloro-2-hydroxybenzaldehyde
2420-26-0
- $0.00
- 99%
- Qingdao RENAS Polymer Material Co., Ltd.
-
- 4-Chloro-2-hydroxybenzaldehyde
2420-26-0
- $1.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 4-Chloro-2-hydroxybenzaldehyde
2420-26-0
- $5.00
- 0.99
- Hebei Fengjia New Material Co., Ltd
