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4-Chloro-2-hydroxybenzaldehyde

4-Chloro-2-hydroxybenzaldehyde structure

CAS No.: 2420-26-0

Chemical Name:: 4-Chloro-2-hydroxybenzaldehyde

Synonyms: 4-Chlorosalicylaldehy;4-chlorosalicylaldehyde;4-Chlorosalicylaldehyde >4-chloro-2-hydoxybenzaldehye;4-chloro-2-hydoxybenzaldehyde;2-hydroxy-4-chlorobenzaldehyde;4-CHLORO-2-HYDROXY-BENZALDEHYDE;Benzaldehyde, 4-chloro-2-hydroxy-;4-Chloro-2-hydroxybenzaldehyde 98%;4-Chloro-2-hydroxy-benzaldehyde ,97%

CBNumber:: CB0132552

Molecular Formula:: C7H5ClO2

Molecular Weight:: 156.57

MDL Number:: MFCD06252499

MOL File:: 2420-26-0.mol

MSDS File:: SDS

Last updated:2026-05-27 17:18:25

Product description	Number	Pack Size	Price
4-Chlorosalicylaldehyde >95.0%(GC)(T)	C2653	1g	$88
4-Chlorosalicylaldehyde >95.0%(GC)(T)	C2653	5g	$350
4-Chloro-2-hydroxybenzaldehyde	431510	250mg	$319
4-Chloro-2-hydroxybenzaldehyde	431510	500mg	$453
4-Chloro-2-hydroxybenzaldehyde Asreported	267602	100mg	$337
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4-Chloro-2-hydroxybenzaldehyde Properties

Melting point	45.0 to 49.0 °C
Boiling point	229.1±20.0 °C(Predicted)
Density	1.404±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Chloroform (Sparingly), Methanol (Slightly)
form	Solid
pka	7.21±0.10(Predicted)
color	Off-White to Pale Brown
InChI	InChI=1S/C7H5ClO2/c8-6-2-1-5(4-9)7(10)3-6/h1-4,10H
InChIKey	QNZWAJZEJAOVPN-UHFFFAOYSA-N
SMILES	C(=O)C1=CC=C(Cl)C=C1O
CAS DataBase Reference	2420-26-0

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

Hazard Codes

Risk Statements

HS Code

2913000090

NFPA 704

	0
2		0

4-Chloro-2-hydroxybenzaldehyde price More Price(76)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	C2653	4-Chlorosalicylaldehyde >95.0%(GC)(T)	2420-26-0	1g	$88	2026-04-30	Buy
TCI Chemical	C2653	4-Chlorosalicylaldehyde >95.0%(GC)(T)	2420-26-0	5g	$350	2026-04-30	Buy
Usbiological	431510	4-Chloro-2-hydroxybenzaldehyde	2420-26-0	250mg	$319	2026-06-03	Buy
Usbiological	431510	4-Chloro-2-hydroxybenzaldehyde	2420-26-0	500mg	$453	2026-06-03	Buy
Usbiological	267602	4-Chloro-2-hydroxybenzaldehyde Asreported	2420-26-0	100mg	$337	2026-06-03	Buy

Product number	Packaging	Price	Buy
C2653	1g	$88	Buy
C2653	5g	$350	Buy
431510	250mg	$319	Buy
431510	500mg	$453	Buy
267602	100mg	$337	Buy

4-Chloro-2-hydroxybenzaldehyde Chemical Properties,Uses,Production

Uses

4-Chloro-2-hydroxybenzaldehyde is an intermediate used to prepare benzodiazepine diones as Hdm2 antagonists. It is also used to synthesize hydroxy-dimethyl-oxo-cyclohexenyl-dimethyl-tetrahydro-xanthenone as oral neuropeptide Y5 receptor antagonist.

Synthesis

50-00-0

108-43-0

2420-26-0

To a 1L three-necked round-bottomed flask was added 3-chlorophenol (33.6 g, 0.3 mol), anhydrous MgCl2 (85.7 g, 0.9 mmol), triethylamine (75.9 g, 0.75 mol) and anhydrous acetone (340 mL). The resulting solution was stirred at 25 °C for 30 min, followed by the addition of paraformaldehyde (45 g, 1.5 mol). The reaction mixture was heated to reflux for 5 h under nitrogen protection. When TLC monitoring showed complete consumption of the feedstock, the acetone was evaporated under reduced pressure. The residue was acidified to pH 3 with 10% hydrochloric acid solution and extracted with ethyl acetate (3 x 150 mL). The organic layers were combined, washed with water, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give a brownish-red oil (18.1 g, 43.1% yield), which can be used directly in subsequent reactions without further purification (Byun et al., 2008; Uini and Lars, 1999).

References

[1] Applied Organometallic Chemistry, 2018, vol. 32, # 2,
[2] Drug Metabolism and Disposition, 2017, vol. 45, # 12, p. 1354 - 1363
[3] Organic and Biomolecular Chemistry, 2017, vol. 15, # 6, p. 1530 - 1536
[4] Organic Letters, 2015, vol. 17, # 23, p. 5824 - 5827
[5] Organic and Biomolecular Chemistry, 2016, vol. 14, # 30, p. 7268 - 7274

4-Chloro-2-hydroxybenzaldehyde Preparation Products And Raw materials

Raw materials

Hexamethylphosphoramide Toluene Paraformaldehyde Chloroform Tetrahydrofuran

Diethyl ether Hydrochloric acid Dichloromethane 3-Chlorophenol Bromoethane

Petroleum ether Magnesium Calcium hydroxide Sodium carbonate

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Preparation Products

2-Benzofurancarboxylic acid, 6-chloro-, 1,1-dimethylethyl ester 2H-1-Benzopyran-3-carboxylic acid, 7-chloro-, ethyl ester 1-Benzoxepin-5-amine, 8-chloro-2,3,4,5-tetrahydro-

4-Chloro-2-hydroxybenzaldehyde Suppliers

Global( 262)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hubei Deli Pharmaceutical Technology Co., Ltd.	+8619237964946	dl@delipharm.com	China	97	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Hebei Fengjia New Material Co., Ltd	+86-0311-87836622 +86-18712993135	sales01@tairunfaz.com	China	8051	58
Qingdao RENAS Polymer Material Co., Ltd.	+86-0532-86867058 +86-18562606086	sales@qdrenas.com	China	1066	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	14026	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29812	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58

Supplier	Advantage
Hubei Deli Pharmaceutical Technology Co., Ltd.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Fengjia New Material Co., Ltd	58
Qingdao RENAS Polymer Material Co., Ltd.	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Changzhou Ansciep Chemical Co., Ltd.	58
Accela ChemBio Inc.	58

View Lastest Price from 4-Chloro-2-hydroxybenzaldehyde manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-01	4-Chloro-2-hydroxybenzaldehyde 2420-26-0		20kg	99%	20 tons	Qingdao RENAS Polymer Material Co., Ltd.
2026-03-20	4-Chloro-2-hydroxybenzaldehyde 2420-26-0	$1.00	1kg	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-05-26	4-Chloro-2-hydroxybenzaldehyde 2420-26-0	$5.00	1kg	0.99	10000	Hebei Fengjia New Material Co., Ltd

4-Chloro-2-hydroxybenzaldehyde
2420-26-0
$0.00
99%
Qingdao RENAS Polymer Material Co., Ltd.

4-Chloro-2-hydroxybenzaldehyde
2420-26-0
$1.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

4-Chloro-2-hydroxybenzaldehyde
2420-26-0
$5.00
0.99
Hebei Fengjia New Material Co., Ltd

4-Chloro-2-hydroxybenzaldehyde Spectrum

4-Chloro-2-hydroxybenzaldehyde(2420-26-0)¹HNMR

2420-26-0(4-Chloro-2-hydroxybenzaldehyde)Related Search:

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2-Chloro-3-hydroxypyridine 3-Hydroxybenzaldehyde Difluorochloromethane 1-AMINO-2-CHLORO-4-HYDROXY-9,10-ANTHRACENEDIONE Buclosamide

4'-CHLORO-2'-HYDROXYACETOPHENONE Xipamide 2,4-DICHLORO-6-HYDROXYBENZALDEHYDE 4-Chloro-2-methoxybenzoic acid Alloclamide

4-Chlorosalicylic acid 7-chloro-4-oxo-4H-chromene-2-carboxylic acid 1-(4-CHLORO-2-HYDROXYPHENYL)PROPAN-1-ONE

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4-CHLORO-2-HYDROXY-BENZALDEHYDE 4-Chloro-2-hydroxy-benzaldehyde ,97% 4-Chlorosalicylaldehy 4-chloro-2-hydoxybenzaldehyde 4-chloro-2-hydoxybenzaldehye 4-chlorosalicylaldehyde 2-hydroxy-4-chlorobenzaldehyde 4-Chlorosalicylaldehyde, 5-Chloro-2-formylphenol 4-Chloro-2-hydroxybenzaldehyde, 95+% 4-Chlorosalicylaldehyde > Benzaldehyde, 4-chloro-2-hydroxy- 4-Bromo-2-fluoro-7-hydroxyacetophenone 4-Chloro-2-hydroxybenzaldehyde 98% 2420-26-0 Aromatic Aldehydes & Derivatives (substituted) Aldehydes Phenyls & Phenyl-Het