akuammine
- CAS No.
- 3512-87-6
- Chemical Name:
- akuammine
- Synonyms
- akuammine;Vincamajoridine;(2S,3E,7aα,12aα,12bβ,15R)-3-Ethylidene-1,3,4,6,7,12b-hexahydro-9-hydroxy-12-methyl-2H,12H-12a,2,7a-(epoxyethanylidene)indolo[2,3-a]quinolizine-15-carboxylic acid methyl ester;2H,12H-12a,2,7a-(Epoxyethanylylidene)indolo[2,3-a]quinolizine-15-carboxylic acid, 3-ethylidene-1,3,4,6,7,12b-hexahydro-9-hydroxy-12-methyl-, methyl ester, (2S,3E,7aS,12aS,12bS,15R)-
- CBNumber:
- CB01334382
- Molecular Formula:
- C22H26N2O4
- Molecular Weight:
- 382.46
- MDL Number:
- MOL File:
- 3512-87-6.mol
| Product description | Number | Pack Size | Price |
| AKUAMMINE 95.00% | PXT0002162 | 5MG | $495.21 |
| Melting point | 316 °C |
|---|---|
| Boiling point | 564.0±50.0 °C(Predicted) |
| alpha | D16 -105.3° (c = 1.31 in pyridine) |
| Density | 1.40±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMF: 2 mg/ml,DMSO: 1 mg/ml,Ethanol: insol,PBS (pH 7.2): insol |
| form | A crystalline solid |
| pka | 7.5(at 25℃) |
| optical activity | -73.420 (c 0.8716, CHCl3) |
| FDA UNII | 0421AQV5W3 |
akuammine Chemical Properties,Uses,Production
Uses
Akuammine is an indole alkaloid that has been found in Picralima nitida and has analgesic activity. It selectively binds to the μ- and κ-opioid receptors over the δ-opioid receptor (Kis=0.3, 1.68, and 10.4 μM for the human receptors, respectively). Akuammine inhibits forskolin-induced cAMP production in HEK293 cells expressing human μ- or κ-opioid receptors (IC50s=2.6 and 0.073 μM, respectively). It increases the latency to withdrawal in the tail-flick or hot plate test in mice when administered at a dose of 60 mg/kg.
References
[1] Creed, et al. Isolation and pharmacological characterization of six opioidergic Picralima nitida alkaloids. J. Nat. Prod. 84(1), 71-80 (2021).
akuammine Preparation Products And Raw materials
Raw materials
Preparation Products
akuammine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32434 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29547 | 58 |
| Tanmo Quality Inspection Technology Co., Ltd. | 4008-099-669 | 23419001name@qq.com | CHINA | 6043 | 58 |
| Cayman Chemical Company | 800-364-9897 | sales@caymanchem.com | China | 6838 | 58 |
| Beijing Xiecheng Biotechnology Co., Ltd. | 18301438069 | CHINA | 153 | 58 |
