Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Structure
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride structure
CAS No.
23007-85-4
Chemical Name:
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
Synonyms
MPTP;MPTP HYDROCHLORIDE;MPTP HCl;0MPTP hydrochloride;Methyl Hydrochloride;23007-85-4/28289-54-5;NSC 139654 Hydrochloride;Pethidine EP Impurity B HCl;MPTP hydrochloride, 10 mM in DMSO;1-METHYL-4-PHENYL-1 2 3 6-TETRAHYDROPYR&
CBNumber:
CB0133791
Molecular Formula:
C12H16ClN
Molecular Weight:
209.72
MDL Number:
MFCD00012790
MOL File:
23007-85-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-30 11:39:11
Request For Quotation

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Properties

Melting point 249.0 to 254.0 °C
storage temp. Inert atmosphere,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form White solid
color white to off-white
Water Solubility water: 100mg/mL
BRN 3707312
Stability Light Sensitive
InChI InChI=1S/C12H15N.ClH/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-7H,8-10H2,1H3;1H
InChIKey KOWJANGMTAZWDT-UHFFFAOYSA-N
SMILES C1(=CCN(C)CC1)C1C=CC=CC=1.Cl
CAS DataBase Reference 23007-85-4
FDA UNII 5O1K9K2EZM
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)Health Hazard (GHS08)
GHS06,GHS08
Signal word  Danger
Hazard statements  H301-H370
Precautionary statements  P260-P264-P270-P301+P310-P405-P501
target organs Nervous system
Hazard Codes  T
Risk Statements  25-39/23/24/25-36/37/38
Safety Statements  45-39-26
RIDADR  2811
WGK Germany  3
RTECS  UT8358950
HS Code  2933.39.9200
HazardClass  6.1(b)
PackingGroup  III
Storage Class 6.1C - Combustible, acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Oral
STOT SE 1

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride price More Price(48)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M0896 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride powder 23007-85-4 10mg $145 2026-04-30 Buy
Sigma-Aldrich M0896 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride powder 23007-85-4 100mg $434 2026-04-30 Buy
Sigma-Aldrich 5.06382 MPTP Hydrochloride - CAS 23007-85-4 - Calbiochem 23007-85-4 10mg $200 2026-04-30 Buy
TCI Chemical M2690 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Hydrochloride >98.0%(HPLC) 23007-85-4 25mg $74 2026-04-30 Buy
TCI Chemical M2690 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Hydrochloride >98.0%(HPLC) 23007-85-4 100mg $217 2026-04-30 Buy
Product number Packaging Price Buy
M0896 10mg $145 Buy
M0896 100mg $434 Buy
5.06382 10mg $200 Buy
M2690 25mg $74 Buy
M2690 100mg $217 Buy

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Chemical Properties, Uses, Production

Chemical Properties

White Solid

Uses

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride is a dopaminergic neurotoxin that reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys.

Uses

MPTP is a neurotoxin used to cause selective destruction of dopaminergic neurons in animal models of parkinsonism. MPTP is metabolized by monoamine oxidase B to produce MPDP+ and MPP+, with MP+ being the active toxic agent. MPP+ induces neurotoxicity primarily by inhibiting complex I of the mitochondrial electron transport chain, resulting in ATP depletion and increased oxidative stress. The key features of different neurotoxic models of Parkinson’s disease, including the MPTP model, have been detailed.[Cayman Chemical]

Biochem/physiol Actions

Dopaminergic neurotoxin.

in vivo

MPTP hydrochloride can be used in animal modeling to create Parkinson's disease models. MPTP replicates naturally occurring neurodegeneration and is useful for studying dopaminergic neuronal degeneration, mitochondrial dysfunction, and neuroinflammation. After injection, MPTP is rapidly metabolized to MPP+, which has a serum half-life of approximately 6 days in sheep.

Induction of Parkinsonism model[4][5][6][7]
Background
MPTP is free to cross the blood-brain barrier and enter the brain, where it is metabolized by monoamine oxidase B (MAO-B) in astrocytes into MPP+, its active & toxic form. MPP+ is taken up by dopamine neurons via a dopamine transporter (DAT), blocking Complex I in the electron transport chain of mitochondria, triggering oxidative stress and mitochondrial breakdown, and finally leading to neuron apoptosis. In Parkinson's disease, it is the loss of neurons in the substantia nigra, the dopamine-producing part of the substantia nigrostriatum system, that causes the disease. Due to the toxic effects of MPTP, it will cause the death of dopamine neurons in the substantia nigra, causing symptoms similar to Parkinson's disease.
Specific Modeling Methods
Mice: C57BL/6 male 8-12 week-old (period: 2 weeks), older mice may be more sensitive
Administration:
Acute model: 14-20 mg/kg ip 4 times a day, two hours apart
Sub-acute model: 20-30 mg/kg ip once daily for 5 days
Note
1. MPTP Hcl is dissolved in normal saline and configured when used.
2. After administration, we can observe whether the mice have symptoms such as reduced activity, staggering walking, twitching, fried hair, increased urination, etc. This behavior may last for 24-48 hours, after which the mice behave basically normally.
3. MPTP is usually sold as MPTP hydrochloride. The molecular weight of MPTP hydrochloride is 209.7. Therefore, it is recommended to take into account the presence of hydrochloride (HCl) when preparing injectable solutions. HCl has a molecular weight of 35.4 and accounts for 17% of MPTP. Thus, if a 20 mg/kg dose of MPTP is to be prepared, the MPTP hydrochloride dose administered is 20 mg kg* 1.17% = 23.4 mg/kg.
4. If multiple injections are given within 1 day, it is best to alternate the injections on both sides. If injected every day, it should be done at the same time. Before each injection, the mice need to be weighed and the dosage volume should be adjusted.
5. Modeling mice may not show behavioral defects of Parkinson's disease. Mice may show individual differences, and the success rate of modeling is generally difficult to reach 100%. Therefore nigrostriatal damage associated with gliosis should be mainly monitored in MPTP mouse studies.
6. High drug dosage/mice weighing less than 22 g/mixing of drugs from different batches/mice not adapting in advance/animal room being too cold may result in a number of deaths. It is recommended that the number of animals in each group be increased, and adjust to the optimal dose according to experimental conditions.
Modeling Indicators
Nigrostriatal injury: Tyrosine hydroxylase in the substantia nigra and striatum is reduced after successful modeling (IHC, IF, WB, etc.);
Other markers: reduction of brain neurotransmitters (DA, DOPAC, 5-HT, HVA, etc.) (detected by HPLC);
Nigrostriatal microglia (IBA1+ cells) and astrocytes (GFAP+ cells) are activated, and the number of α-syn aggregates in the substantia nigra .
Correlated Product(s): /
Opposite Product(s): HY-W013494

Purification Methods

Purify MPTP by recrystallisation from pKEst ~ Me2CO/isoPrOH. The free base has m 40-42o(from heptane), b 99-100o/1.3mm, 128-132o/12mm, (137-142o/0.8mm), n 25 1.5347. The hydrochloride has m 251-252o(from Me2CO/isoPrOH) [Schmidle & Mansfield J Am Chem Soc 78 425 1956, Defeudis Drug Dev Res 15 1 1988, Beilstein 20 III/IV 3240, 20/7 V 121.]

References

[1] Lun-Yi Zang, Hara P Misra. “Inactivation of acetylcholinesterase by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride.” Molecular and Cellular Biochemistry 254 1–2 (2003): 131–6.
[2] Gregory L. Willis, Alan D. Robertson. “Recovery from experimental Parkinson’s disease in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride treated marmoset with the melatonin analogue ML-23.” Pharmacology Biochemistry and Behavior 80 1 (2005): Pages 9-26.
[3] Atsushi Fujita. “Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson’s disease animal model.” Journal of Neuroinflammation (2018): 227.

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Suppliers

Global Suppliers ( 284)
Supplier Tel Email Country ProdList Advantage
UHN Shanghai Research & Development Co., Ltd. 021-58958002 18930822973 sales@uhnshanghai.com China 997 58
Cangzhou Enke Pharma-tech Co., Ltd. 0317-5296180 15533709196 enkepharma@126.com China 2494 55
Shanghai Yunpun industrial Co.,Ltd 21-61726900 15202122459; sales@yunpun.com China 494 58
Shanghai Hecheng Medical Technology Co., LTD 13564747822 669027880@qq.com China 1123 58
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 sales@meilune.com China 4765 58
SINO High Goal Chemical Technology Co., Ltd. 021-57646680 18306277365 guoxin@chembiobanksh.com China 2829 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
future industrial shanghai co., ltd 400-0066400 13621662912 sales@jonln.com China 1989 65
SelectLab Chemicals GmbH +49-(0)2383-919350 info@selectlab.de Germany 393 55
Supplier Advantage
UHN Shanghai Research & Development Co., Ltd. 58
Cangzhou Enke Pharma-tech Co., Ltd. 55
Shanghai Yunpun industrial Co.,Ltd 58
Shanghai Hecheng Medical Technology Co., LTD 58
Dalian Meilun Biotech Co., Ltd. 58
SINO High Goal Chemical Technology Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
3B Pharmachem (Wuhan) International Co.,Ltd. 69
future industrial shanghai co., ltd 65
SelectLab Chemicals GmbH 55

View Latest Price from 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
MPTP hydrochloride pictures 2026-08-30 MPTP hydrochloride
23007-85-4
 $30.00-77.00 99.63% 10g TargetMol Chemicals Inc.
China 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride pictures 2021-07-09 China 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
23007-85-4
 $7.00 1KG 98% 1000 Kilogram/Kilograms per Month Hebei Xibaijie Biotechnology Co., Ltd.
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride pictures 2021-07-09 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
23007-85-4
 $7.00 1KG 98% 1000 Kilogram/Kilograms per Month Hebei Xibaijie Biotechnology Co., Ltd.

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Spectrum

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride(23007-85-4)MS1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride(23007-85-4)1HNMR

23007-85-4 (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride) Related Search:

4-Pyridineacetic acid hydrochloride Topotecan hydrochloride 3-Pyridylacetic acid hydrochloride 2,6-Lutidine Pyridine hydrochloride
2,4,6-Collidine 2-Pyridylacetic acid hydrochloride Bensulfuron methyl 4-Methylpyridine Azamethiphos
Chlorodimethylphenylsilane 4-Phenylpyridine Kresoxim-methyl Methylparaben Thiophanate-methyl
Phenyl valerate Methyl Methyl bromide

1of4

1-methyl-4-phenyl-1,2,3,6-tetrahydro pyridine HCL 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride, >=99% Pyridine,1,2,3,6-tetrahydro-1-methyl-4-phenyl-, hydrochloride (1:1) 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE MPTP Hydrochloride - CAS 23007-85-4 - Calbiochem 1,2,3,6-tetrahydro-1-methyl-4-phenylpyridinehydrochloride 1,2,3,6-tetrahydro-1-methyl-4-phenyl-pyridinhydrochloride 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridinehydr 1-methyl-4-phenyl-1,2,3,6-tetra-*hydropyridine hy 1-METHYL-4-PHENYL-1 2 3 6-TETRAHYDROPYR& 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride,MPTP hydrochloride 1- Methyl-4-phenyl -1,2,3,6-four hydrogen pyridinehydrochloride NSC 139654 Hydrochloride Methyl Hydrochloride 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Hydrochloride > 23007-85-4/28289-54-5 1,2,3,6-tetrahydro-1-methyl-4-phenyl-Pyridine hydrochloride (1:1) Pethidine EP Impurity B HCl 0MPTP hydrochloride 1-methyl-4-phenyl-3,6-dihydro-2H-pyridine MPTP : 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride MPTP hydrochloride, 10 mM in DMSO MPTP Hydrochloride ≥98% (AgNO3), powder, dopaminergic neurotoxin 1,2,3,6-Tetrahydro-1-methyl-4-phenylpyridine HCl MPTP MPTP HCl MPTP HYDROCHLORIDE 23007-85-4 C12H15NHCl Heterocyclic Compounds Neurochemicals