Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>IDO/Tubulin-IN-2

IDO/Tubulin-IN-2

IDO/Tubulin-IN-2 Structure
IDO/Tubulin-IN-2 structure
CAS No.
2409479-24-7
Chemical Name:
IDO/Tubulin-IN-2
Synonyms
IDO/Tubulin-IN-2;Benzoic acid, 3-[(4,9-dihydro-4,9-dioxo-1H-naphtho[2,3-d]triazol-1-yl)methyl]-, 2-[1-[[3-[[2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenoxy]carbonyl]phenyl]methyl]-1H-1,2,3-triazol-4-yl]ethyl ester
CBNumber:
CB014133606
Molecular Formula:
C48H40N6O10
Molecular Weight:
860.87
MDL Number:
MOL File:
2409479-24-7.mol
Last updated:2025-05-19 13:47:32
Request For Quotation

IDO/Tubulin-IN-2 Properties

Boiling point 1056.388±75.00 °C(Press: 760.00 Torr)(predicted)
Density 1.347±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka 0.780±0.12(predicted)

IDO/Tubulin-IN-2 Chemical Properties,Uses,Production

Uses

IDO/Tubulin-IN-2 (HT2) is a potent TDO and tubulin inhibitor. IDO/Tubulin-IN-2 also shows potent activity against U87, HepG2, A549, HCT-116, and LO2 cancer cell lines, with IC50 values of 0.43, 0.036, 0.041, 0.095 and 1.04 μM, respectively. IDO/Tubulin-IN-2 remarkably promotes the antitumor activity[1].

in vivo

IDO/Tubulin-IN-2 (HT2) (30 mg/kg; IV; daily, for 21 days) significantly inhibits tumor growth[1].
IDO/Tubulin-IN-2 (30 mg/kg; IV; 29 days) has effective antitumor immunity ability to promote the tumor therapeutic efficacy[1].

Animal Model:ICR mice (mouse liver cancer xenograft models, established by subcutaneous inoculation of H22 cells)[1]
Dosage:30 mg/kg
Administration:Intravenously injected via a tail vein; daily, for 21 days
Result:Significantly inhibited tumor growth.
Animal Model:Male A549 tumor xenograft BALB/c nude mice (5 weeks, 18-22 g)[1]
Dosage:30 mg/kg
Administration:IV, daily, for 29 days
Result:Had effective antitumor immunity ability to promote the tumor therapeutic efficacy.

References

[1] Hua S, Chen F, Gou S. Microtubule inhibitors containing immunostimulatory agents promote cancer immunochemotherapy by inhibiting tubulin polymerization and tryptophan-2,3-dioxygenase. Eur J Med Chem. 2020;187:111949. DOI:10.1016/j.ejmech.2019.111949

IDO/Tubulin-IN-2 Preparation Products And Raw materials

Raw materials

Preparation Products

IDO/Tubulin-IN-2 Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19939 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 26070 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 58

View Lastest Price from IDO/Tubulin-IN-2 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
IDO/Tubulin-IN-2 pictures 2025-04-29 IDO/Tubulin-IN-2
2409479-24-7
 US $2800.00-2180.00 / mg 10g TargetMol Chemicals Inc.
IDO/Tubulin-IN-2 Benzoic acid, 3-[(4,9-dihydro-4,9-dioxo-1H-naphtho[2,3-d]triazol-1-yl)methyl]-, 2-[1-[[3-[[2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenoxy]carbonyl]phenyl]methyl]-1H-1,2,3-triazol-4-yl]ethyl ester 2409479-24-7