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RXFP2 agonist 2

RXFP2 agonist 2 Structure
RXFP2 agonist 2 structure
CAS No.
2971704-85-3
Chemical Name:
RXFP2 agonist 2
Synonyms
RXFP2 agonist 2;Pyrazino[2,1-c][1,4]benzodiazepine-6,12(2H,11H)-dione, 8-[3,5-bis(trifluoromethyl)phenyl]-1,3,4,12a-tetrahydro-2-[2-[2-iodo-4-(trifluoromethoxy)phenoxy]acetyl]-, (12aS)-
CBNumber:
CB014289662
Molecular Formula:
C29H19F9IN3O5
Molecular Weight:
787.37
MDL Number:
MOL File:
2971704-85-3.mol
Last updated:2025-05-19 13:47:35
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RXFP2 agonist 2 Properties

Boiling point 781.085±60.00 °C(Press: 760.00 Torr)(predicted)
Density 1.807±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka 12.434±0.20(predicted)

RXFP2 agonist 2 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0620407 RXFP2 agonist 2 2971704-85-3 5mg $617 2026-06-04 Buy
ChemScene CS-0620407 RXFP2 agonist 2 2971704-85-3 10mg $997 2026-06-04 Buy
ChemScene CS-0620407 RXFP2 agonist 2 2971704-85-3 25mg $2004 2026-06-04 Buy
ChemScene CS-0620407 RXFP2 agonist 2 2971704-85-3 50mg $3250 2026-06-04 Buy
ChemScene CS-0620407 RXFP2 agonist 2 2971704-85-3 100mg $5200 2026-06-04 Buy
Product number Packaging Price Buy
CS-0620407 5mg $617 Buy
CS-0620407 10mg $997 Buy
CS-0620407 25mg $2004 Buy
CS-0620407 50mg $3250 Buy
CS-0620407 100mg $5200 Buy

RXFP2 agonist 2 Chemical Properties, Uses, Production

Uses

RXFP2 agonist 2 is a selective, orally active and allosteric RXFP2 agonist with an EC50 value of 0.38 μM. RXFP2 agonist 2 induces osteoblast mineralization. RXFP2 agonist 2 increases bone formation in female mice. RXFP2 agonist 2 has the potential for the research of osteoporosis[1].

in vivo

RXFP2 agonist 2 (10 mg/kg; p.o.; 3 times per week for 8 weeks) promotes bone formation in female mice[1].

Animal Model:8-week-old WT C57BL/6J female mice[1]
Dosage:3 mg/kg for i.v.; 10 mg/kg for p.o.
Administration:I.v. or p.o.
Result:Exhibited a half-life of between 4-6.5h depending on the route of administration, with no accumulation at 10mg/kg, and oral bioavailability around 25-31%.
Animal Model:8-week-old WT C57BL/6J female mice[1]
Dosage:10 mg/kg
Administration:P.o.; 3 times per week for 8 weeks
Result:Increased bone formation in mouse with significantly increased in Tb.N and Tb.Th, and increased BV/TV and decreased Tb.Sp.

References

[1] Esteban-Lopez M, et al. Discovery of small molecule agonists of the Relaxin Family Peptide Receptor 2. Commun Biol. 2022 Nov 4;5(1):1183. DOI:10.1038/s42003-022-04143-9

RXFP2 agonist 2 Preparation Products And Raw materials

Raw materials

Preparation Products

2971704-85-3 (RXFP2 agonist 2) Related Search:

RXFP1 receptor agonist-5 RXFP3/4 agonist 1 Cyclohexanecarboxylic acid, 4-[2-fluoro-4-methoxy-5-[[[(1S,2R,3S,4R)-3-[[[(1-methylcyclobutyl)methyl]amino]carbonyl]bicyclo[2.2.1]hept-2-yl]amino]carbonyl]phenoxy]-1-methyl-, cis- AZ7976 RXFP1 receptor agonist-2
NA

1of2

RXFP2 agonist 2 Pyrazino[2,1-c][1,4]benzodiazepine-6,12(2H,11H)-dione, 8-[3,5-bis(trifluoromethyl)phenyl]-1,3,4,12a-tetrahydro-2-[2-[2-iodo-4-(trifluoromethoxy)phenoxy]acetyl]-, (12aS)- 2971704-85-3