Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>1,6-Naphthyridine-6(5H)-ethanamine, 2-[[4-(1-cyclopropyl-4-fluoro-2-methyl-1H-benzimidazol-6-yl)-5-fluoro-2-pyrimidinyl]amino]-7,8-dihydro-N,N-dimethyl-, (2Z)-2-butenedioate (1:1)

1,6-Naphthyridine-6(5H)-ethanamine, 2-[[4-(1-cyclopropyl-4-fluoro-2-methyl-1H-benzimidazol-6-yl)-5-fluoro-2-pyrimidinyl]amino]-7,8-dihydro-N,N-dimethyl-, (2Z)-2-butenedioate (1:1)

1,6-Naphthyridine-6(5H)-ethanamine, 2-[[4-(1-cyclopropyl-4-fluoro-2-methyl-1H-benzimidazol-6-yl)-5-fluoro-2-pyrimidinyl]amino]-7,8-dihydro-N,N-dimethyl-, (2Z)-2-butenedioate (1:1) Structure
1,6-Naphthyridine-6(5H)-ethanamine, 2-[[4-(1-cyclopropyl-4-fluoro-2-methyl-1H-benzimidazol-6-yl)-5-fluoro-2-pyrimidinyl]amino]-7,8-dihydro-N,N-dimethyl-, (2Z)-2-butenedioate (1:1) structure
CAS No.
2765997-88-2
Chemical Name:
1,6-Naphthyridine-6(5H)-ethanamine, 2-[[4-(1-cyclopropyl-4-fluoro-2-methyl-1H-benzimidazol-6-yl)-5-fluoro-2-pyrimidinyl]amino]-7,8-dihydro-N,N-dimethyl-, (2Z)-2-butenedioate (1:1)
Synonyms
SPH4336;CDK4/6-IN-21 maleate;1,6-Naphthyridine-6(5H)-ethanamine, 2-[[4-(1-cyclopropyl-4-fluoro-2-methyl-1H-benzimidazol-6-yl)-5-fluoro-2-pyrimidinyl]amino]-7,8-dihydro-N,N-dimethyl-, (2Z)-2-butenedioate (1:1)
CBNumber:
CB014685716
Molecular Formula:
C27H30F2N8.C4H4O4
Molecular Weight:
620.65
MDL Number:
MOL File:
2765997-88-2.mol
MSDS File:
SDS
Last updated:2025-04-17 18:22:24
Request For Quotation

1,6-Naphthyridine-6(5H)-ethanamine, 2-[[4-(1-cyclopropyl-4-fluoro-2-methyl-1H-benzimidazol-6-yl)-5-fluoro-2-pyrimidinyl]amino]-7,8-dihydro-N,N-dimethyl-, (2Z)-2-butenedioate (1:1) Chemical Properties, Uses, Production

Uses

CDK4/6-IN-21 maleate (compound I-52) is a CDK4/6 inhibitor with IC50 values of 3.88 and 3.31 nM for CDK4 and CDK6, respectively. CDK4/6-IN-21 maleate has antitumor activity[1].

IC 50

CDK4: 3.88 nM (IC50); CDK6: 3.31 nM (IC50)

References

[1] Guangxin Xia J, et al. Nitrogen-containing fused heterocyclic compound, as well as preparation method, intermediate, composition and application thereof. WO2017114512A1. 2017-07-06.

1,6-Naphthyridine-6(5H)-ethanamine, 2-[[4-(1-cyclopropyl-4-fluoro-2-methyl-1H-benzimidazol-6-yl)-5-fluoro-2-pyrimidinyl]amino]-7,8-dihydro-N,N-dimethyl-, (2Z)-2-butenedioate (1:1) Preparation Products And Raw materials

Raw materials

Preparation Products

1,6-Naphthyridine-6(5H)-ethanamine, 2-[[4-(1-cyclopropyl-4-fluoro-2-methyl-1H-benzimidazol-6-yl)-5-fluoro-2-pyrimidinyl]amino]-7,8-dihydro-N,N-dimethyl-, (2Z)-2-butenedioate (1:1) Suppliers

Global Suppliers ( 3)
Supplier Tel Email Country ProdList Advantage
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9729 58
Shanghai Star Pharmaceutical Chemical Technology Co., Ltd. 021-58521787 17701827760 starpharmsh@gmail.com China 301 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Supplier Advantage
Shanghai Chaolan Chemical Technology Center 58
Shanghai Star Pharmaceutical Chemical Technology Co., Ltd. 58
TargetMol Chemicals Inc. 58

2765997-88-2 (1,6-Naphthyridine-6(5H)-ethanamine, 2-[[4-(1-cyclopropyl-4-fluoro-2-methyl-1H-benzimidazol-6-yl)-5-fluoro-2-pyrimidinyl]amino]-7,8-dihydro-N,N-dimethyl-, (2Z)-2-butenedioate (1:1)) Related Search:

N-(5-(difluoromethoxy)-1H-pyrazol-3-yl)-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-pyrazolo[3,4-b]pyrazin-6-amine CDK12-CCNK HETERODIMER Protein, HUMAN (SF9) CDK3-CCNE1 HETERODIMER Protein, HUMAN (SF9) THZ1 OTS964 hydrochloride
GSK-3326595

1of2

1,6-Naphthyridine-6(5H)-ethanamine, 2-[[4-(1-cyclopropyl-4-fluoro-2-methyl-1H-benzimidazol-6-yl)-5-fluoro-2-pyrimidinyl]amino]-7,8-dihydro-N,N-dimethyl-, (2Z)-2-butenedioate (1:1) CDK4/6-IN-21 maleate SPH4336 2765997-88-2