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tert-Butyl N-[4-(aminomethyl)phenyl]carbamate

tert-Butyl N-[4-(aminomethyl)phenyl]carbamate structure

CAS No.: 220298-96-4

Chemical Name:: tert-Butyl N-[4-(aminomethyl)phenyl]carbamate

Synonyms: 4-(Boc-aMino)benzylaMine;4-(N-Boc-amino)benzylamine;4-AMinoMethyl-N-Boc-aniline;4-(Aminomethy)-1-N-Boc-aniline;4-(AMINOMETHYL)-1-N-BOC-ANILINE;2-(4-CHLOROPHENOXY)MALONDIALDEHYDE;4-Aminobenzylamine, 4-BOC protected;4-(TERT-BUTOXYCARBONYLAMINO)BENZYLAMINE;4-Aminobenzylamine, 4-BOC protected 95+%;TERT-BUTYL 4-(AMINOMETHYL)PHENYL CARBAMATE

CBNumber:: CB0148986

Molecular Formula:: C12H18N2O2

Molecular Weight:: 222.28

MDL Number:: MFCD02183573

MOL File:: 220298-96-4.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:46

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tert-Butyl N-[4-(aminomethyl)phenyl]carbamate Properties

Melting point	64-68 °C(lit.)
Boiling point	300.1±25.0 °C(Predicted)
Density	1.120±0.06 g/cm3(Predicted)
storage temp.	2-8°C, protect from light, stored under nitrogen
pka	13.68±0.70(Predicted)
form	solid
color	white
CAS DataBase Reference	220298-96-4(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H317

Precautionary statements

P280-P301+P312+P330-P302+P352

Hazard Codes

Xi,C,Xn

Risk Statements

36/37/38-34-22-43

Safety Statements

26-36-45-36/37/39-22-36/37

WGK Germany

HazardClass

IRRITANT

HS Code

2922290090

NFPA 704

	1
3		1

tert-Butyl N-[4-(aminomethyl)phenyl]carbamate price More Price(29)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	737283	4-(Boc-amino)benzylamine 95%	220298-96-4	500mg	$100	2023-06-20	Buy
TRC	B603058	4-(Boc-amino)benzylamine	220298-96-4	5g	$700	2021-12-16	Buy
AK Scientific	V0510	4-(Aminomethy)-1-N-Boc-aniline	220298-96-4	10g	$631	2021-12-16	Buy
American Custom Chemicals Corporation	CHM0015475	(4-AMINO METHYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER 95.00%	220298-96-4	1G	$679.37	2021-12-16	Buy
American Custom Chemicals Corporation	CHM0015475	(4-AMINO METHYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER 95.00%	220298-96-4	5G	$1143.68	2021-12-16	Buy

Product number	Packaging	Price	Buy
737283	500mg	$100	Buy
B603058	5g	$700	Buy
V0510	10g	$631	Buy
CHM0015475	1G	$679.37	Buy
CHM0015475	5G	$1143.68	Buy

tert-Butyl N-[4-(aminomethyl)phenyl]carbamate Chemical Properties,Uses,Production

Uses

4-(Boc-amino)benzylamine is used in preparation of degradation agents for Cyclin dependent kinase useful for the treatment of cancer.

Synthesis

143090-18-0

tert-Butyl N-[4-(aminomethyl)phenyl]carbamate

220298-96-4

General procedure for the synthesis of 4-aminomethyl-N-Boc-aniline from N-BOC-4-aminobenzonitrile: 4-(tert-butoxycarbonylamino)benzyl cyanide (1 g, 4.58 mmol) was dissolved in a solvent mixture of THF/isopropanol (1:1, 142 mL) and 10% Pd/C (Degussa type E101, 0.56 g, 0.26 mmol) was added . The reaction system was added via syringe under nitrogen protection. After purging the reaction mixture with nitrogen, it was hydrogenated overnight under 50 psi hydrogen pressure. Upon completion of the reaction, the catalyst was removed by Celite filtration. The filter cake was washed thoroughly with isopropanol (100 mL) and THF (100 mL). The filtrate was concentrated in vacuum and the resulting crude product was purified by silica gel column chromatography and separated using a methanol solution of DCM/2M ammonia (gradient elution procedure: 1:0 to 95:5 for 30 min; 95:5 for 3 min; 95:5 to 9:1 for 30 min; 9:1 for 30 min) to afford the target product, 4-aminomethyl-N-Boc-aniline (0.364 g, 36% yield) . Mass spectrum (ES-) m/z: 220.1 ([M-H]-).

References

[1] Patent: WO2007/28083, 2007, A2. Location in patent: Page/Page column 112

tert-Butyl N-[4-(aminomethyl)phenyl]carbamate Preparation Products And Raw materials

Raw materials

TERT-BUTYL 4-CYANOPHENYLCARBAMATE Tetrahydrofuran Isopropyl alcohol Hydrogen

Preparation Products

tert-Butyl N-[4-(aminomethyl)phenyl]carbamate Suppliers

Global( 132)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29734	60
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29800	58
Richest Group Ltd	18017061086	oled@richest-group.com	CHINA	5600	58
Win-Win chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	sales@win-winchemical.com	China	14360	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52846	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471	sales@sarms4muscle.com	China	10473	58
CD Chemical Group Limited	+8615986615575	info@codchem.com	China	20342	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Accela ChemBio Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Richest Group Ltd	58
Win-Win chemical CO., Limited	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Zhejiang J&C Biological Technology Co.,Limited	58
CD Chemical Group Limited	58

View Lastest Price from tert-Butyl N-[4-(aminomethyl)phenyl]carbamate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-08-11	tert-Butyl N-[4-(aminomethyl)phenyl]carbamate 220298-96-4	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
	2019-12-26	tert-Butyl N-[4-(aminomethyl)phenyl]carbamate 220298-96-4	US $1.00 / KG	1KG	99%	100KG	Career Henan Chemical Co

tert-Butyl N-[4-(aminomethyl)phenyl]carbamate
220298-96-4
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

tert-Butyl N-[4-(aminomethyl)phenyl]carbamate
220298-96-4
US $1.00 / KG
99%
Career Henan Chemical Co

tert-Butyl N-[4-(aminomethyl)phenyl]carbamate Spectrum

tert-Butyl N-[4-(aminomethyl)phenyl]carbamate(220298-96-4)¹HNMR

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2-(4-CHLOROPHENOXY)MALONDIALDEHYDE 4-(TERT-BUTOXYCARBONYLAMINO)BENZYLAMINE (4-AMINOMETHYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER (4-AMINOMETHYL-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER 4-(AMINOMETHYL)-1-N-BOC-ANILINE 4-Aminobenzylamine, 4-BOC protected 95+% TERT-BUTYL N-[4-(AMINOMETHYL)PHENYL]CARBAMATE TERT-BUTYL 4-(AMINOMETHYL)PHENYL CARBAMATE 4-(Aminomethy)-1-N-Boc-aniline 4-(N-Boc-amino)benzylamine 4-AMinoMethyl-N-Boc-aniline 4-Aminobenzylamine, 4-BOC protected tert-Butyl [4-(aminomethyl)phenyl]carbamate, 4-(Aminomethyl)aniline, 1-BOC protected 4-(Boc-aMino)benzylaMine Carbamic acid, N-[4-(aminomethyl)phenyl]-, 1,1-dimethylethyl ester 4-(Aminomethyl)-N-(tert-butoxycarbonyl)aniline tert-Butyl N-[4-(aminomethylphenyllcarbamate 220298-96-4