3-BROMO-4-METHOXY-BENZENESULFONYL CHLORIDE
- CAS No.
- 23094-96-4
- Chemical Name:
- 3-BROMO-4-METHOXY-BENZENESULFONYL CHLORIDE
- Synonyms
- 3-broMo-4-Methoxybenzene-1-sulfonyl chloride;3-Bromo-4-methoxybenzenesulfonylchloride,97%;Benzenesulfonyl chloride, 3-bromo-4-methoxy-;3-Bromo-4-methoxybenzenesulfonyl chloride 97%;3-bromo-4-methoxybenzenesulfonyl chloride(SALTDATA: FREE)
- CBNumber:
- CB01492572
- Molecular Formula:
- C7H6BrClO3S
- Molecular Weight:
- 285.54
- MDL Number:
- MFCD03989643
- MOL File:
- 23094-96-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3-Bromo-4-methoxybenzenesulfonyl chloride 97% | 749346 | 1g | $34 |
| 3-Bromo-4-methoxy-benzenesulfonyl chloride >96% | OR480728 | 250mg | $21 |
| 3-Bromo-4-methoxy-benzenesulfonyl chloride >96% | OR480728 | 1g | $24 |
| 3-Bromo-4-methoxy-benzenesulfonyl chloride >96% | OR480728 | 5g | $89 |
| 3-Bromo-4-methoxy-benzenesulfonyl chloride >96% | OR480728 | 25g | $437 |
| Melting point | 83-88°C |
|---|---|
| Boiling point | 366.0±27.0 °C(Predicted) |
| Density | 1.717±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | solid |
| Appearance | Off-white to pink Solid |
| Sensitive | Moisture Sensitive |
| InChI | 1S/C7H6BrClO3S/c1-12-7-3-2-5(4-6(7)8)13(9,10)11/h2-4H,1H3 |
| InChIKey | LTVLATJRJIBHDR-UHFFFAOYSA-N |
| SMILES | COc1ccc(cc1Br)S(Cl)(=O)=O |
| CAS DataBase Reference | 23094-96-4 |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H314 | |||||||||
| Precautionary statements | P260-P270-P280-P301+P312-P303+P361+P353-P305+P351+P338 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 22-34 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | UN 3261 8 / PGII | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 8 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2930909899 | |||||||||
| Storage Class | 8A - Combustible corrosive hazardous materials | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Skin Corr. 1B |
|||||||||
| Limited Quantities | 1 Kg (2.2 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
3-BROMO-4-METHOXY-BENZENESULFONYL CHLORIDE price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 749346 | 3-Bromo-4-methoxybenzenesulfonyl chloride 97% | 23094-96-4 | 1g | $34 | 2023-06-20 | Buy |
| Apolloscientific | OR480728 | 3-Bromo-4-methoxy-benzenesulfonyl chloride >96% | 23094-96-4 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR480728 | 3-Bromo-4-methoxy-benzenesulfonyl chloride >96% | 23094-96-4 | 1g | $24 | 2026-06-04 | Buy |
| Apolloscientific | OR480728 | 3-Bromo-4-methoxy-benzenesulfonyl chloride >96% | 23094-96-4 | 5g | $89 | 2026-06-04 | Buy |
| Apolloscientific | OR480728 | 3-Bromo-4-methoxy-benzenesulfonyl chloride >96% | 23094-96-4 | 25g | $437 | 2026-06-04 | Buy |
3-BROMO-4-METHOXY-BENZENESULFONYL CHLORIDE Chemical Properties,Uses,Production
Synthesis
578-57-4
23094-96-4
General procedure for the synthesis of 3-bromo-4-methoxybenzene-1-sulfonyl chloride from 2-bromoanisole: 2-bromo-1-methoxybenzene (1.87 g, 10.0 mmol) was dissolved in chloroform (5 mL), and the solution was cooled in an iced salt bath to -5 °C to 0 °C. Chlorosulfonic acid (2.0 mL, 30.0 mmol) was slowly added dropwise over 30 minutes, and after completion of the dropwise addition, the reaction mixture was gradually warmed to room temperature over 1 hour. Subsequently, the reaction mixture was poured onto crushed ice and transferred to a dispensing funnel. The aqueous layer was separated and extracted twice with chloroform. The organic layers were combined, dried and concentrated to give 3-bromo-4-methoxybenzenesulfonyl chloride (2.80 g, 98%). 3-Bromo-4-methoxybenzenesulfonyl chloride (2.80 g, 9.8 mmol) was dissolved in dichloromethane (30 mL), triethylamine (1.76 mL, 12.6 mmol) was added to the solution, followed by slow dropwise addition of tert-butylamine (1.33 mL, 12.6 mmol). The reaction mixture was allowed to stand for 2 hours and then poured into a mixture of 5% citric acid solution and dichloromethane. The organic layer was separated and the aqueous layer was extracted twice with dichloromethane. The organic layers were combined, dried and concentrated. The crude product was recrystallized by ethyl acetate/hexane mixed solvent to give 3-bromo-N-tert-butyl-4-methoxybenzenesulfonamide (2.43 g, 77%).
References
[1] Patent: WO2004/50637, 2004, A2. Location in patent: Page 68-69
[2] Patent: WO2004/62661, 2004, A1. Location in patent: Page/Page column 24-25; 37-38
[3] Patent: US2015/25068, 2015, A1. Location in patent: Paragraph 0794
[4] Journal of the Chemical Society [Section] C: Organic, 1969, p. 1341 - 1345
[5] Bioorganic and Medicinal Chemistry Letters, 1997, vol. 7, # 4, p. 485 - 488
3-BROMO-4-METHOXY-BENZENESULFONYL CHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
3-BROMO-4-METHOXY-BENZENESULFONYL CHLORIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
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| SUZHOU SENFEIDA CHEMICAL CO.,LTD | +86-0512-83500002 +8618662433356 | 3899766280@qq.com | China | 26362 | 58 |
| Lianhe Aigen Pharmatech Co.,Ltd. | +86-18918657159; +undefined+undefined18918657159 | sales@lianhe-aigen.com | China | 300 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
