Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Thiamine chloride

Thiamine chloride

Thiamine chloride Structure
Thiamine chloride structure
CAS No.
59-43-8
Chemical Name:
Thiamine chloride
Synonyms
Vitamin B1;thiamin;VITAMIN B1(THIAMINE)(BASF)(SH);aneurine;ViatmineB1;THIAMIMEMONOCHLORIDE;VITAMIN B1(THIAMINE)(SH);Thiamine chloride vitamin B1;Vitamin B1 Mononitrate (Mono);b-amin
CBNumber:
CB0154385
Molecular Formula:
C12H17ClN4OS
Molecular Weight:
300.81
MDL Number:
MFCD00044586
MOL File:
59-43-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-24 18:39:39
Request For Quotation

Thiamine chloride Properties

Melting point 248 °C (decomp)
Density 1.3175 (rough estimate)
refractive index 1.5630 (estimate)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMSO : 6 mg/mL (19.95 mM)
form Solid
color White to off-white
InChI InChI=1S/C12H17N4OS.ClH/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);1H/q+1;/p-1
InChIKey MYVIATVLJGTBFV-UHFFFAOYSA-M
SMILES O([H])CCC1=C(C)[N+](=CS1)CC1C=NC(=NC=1N)C.[Cl-]
LogP -3.930 (est)
CAS DataBase Reference 59-43-8(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS) THIAMINE
FDA 21 CFR 101.9; 104.20; 104.47
EWG's Food Scores 1
NCI Dictionary of Cancer Terms vitamin B1
FDA UNII X66NSO3N35
EPA Substance Registry System Thiamine (59-43-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H312-H332
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501
RTECS  XI7350000
TSCA  TSCA listed
Hazardous Substances Data 59-43-8(Hazardous Substances Data)

Thiamine chloride price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-7793 Thiamine monochloride 99.96% 59-43-8 500mg $27 2026-06-04 Buy
ChemScene CS-7793 Thiamine monochloride 99.96% 59-43-8 1g $32 2026-06-04 Buy
ChemScene CS-7793 Thiamine monochloride 99.96% 59-43-8 5g $54 2026-06-04 Buy
ChemScene CS-7793 Thiamine monochloride 99.96% 59-43-8 10g $76 2026-06-04 Buy
AK Scientific R436 Vitamin B1 98% 59-43-8 1g $101 2026-06-04 Buy
Product number Packaging Price Buy
CS-7793 500mg $27 Buy
CS-7793 1g $32 Buy
CS-7793 5g $54 Buy
CS-7793 10g $76 Buy
R436 1g $101 Buy

Thiamine chloride Chemical Properties,Uses,Production

Originator

Thiamine chloride,Sopharma

Uses

Vitamin B1 is used in method for cultivating tremella strain. Also, it is protein compound liquid comprising collagen and Rhodiola rosea extract or preparing injection to remove skin wrinkle.

Definition

ChEBI: Thiamine(1+) chloride is a vitamin B1 and an organic chloride salt. It contains a thiamine(1+).

Manufacturing Process

2 Methods of preparation of thiamine:
1. 3-Ethoxypropionitrile reacted with diethoxymethoxy-ethane and 3-ethoxy- 2-methoxymethylenpropionitrile was obtained.
Then to the 3-ethoxy-2-methoxymethylenpropionitrile acetamidine was added and reaction mixture was stirred to give 4-amino-5-ethoxy-methyl-2- methylpyrimidine.
The 4-amino-5-ethoxy-methyl-2-methylpyrimidine was treated by hydrobromic acid to afford 4-amino-5-bromomethyl-2-methylpyrimidine hydrobromide.
The 4-amino-5-bromomethyl-2-methylpyrimidine hydrobromide reacted with 5-(2-hydroxyethyl)-4-methylthiazole in the presence of hydrobromic acid and as the result thiaminbromide was produced. For changing of the thiaminbromide to the thiamincloride the thiaminbromide was treated by AgCl.
2. To diethoxymethoxy-ethane malononitrile was added and ethoxymethylenmalononitrile was obtained. The ethoxymethylen-malononitrile reacted with acetamidine as a result 4-amino-5-cyano-2-methylpyrimidine was produced, which was reduced by H2/Raney-Ni to 4-amino-5-aminomethyl-2- methylpyrimidine.
To the 4-amino-5-aminomethyl-2-methylpyrimidine 1-acetoxy-3-chloropentan- 4-one was added in the presence CS2 and NH3, and reaction mixture was stirred, then to this mixture hydrochloric acid was added and thiamin (base) was obtained.
To thiamin (base) H2O2 and hydrocloricum acid are added, in the result reaction the thiamine chloride was obtained.

Therapeutic Function

Enzyme cofactor vitamin, Antineuritic

General Description

Thiamine, the preferred name for vitamin B1, holds a prominent place in the history of vitamin discovery because beriberi, the disease resulting from insufficient thiamine intake, was one of the earliest recognized deficiency diseases.

Biological Activity

Some earlier designations for this substance included aneurin, antineuritic factor, antiberiberi factor, and oryzamin. Thiamine is metabolically active as thiamine pyrophosphate (TPP).
TPP functions as a coenzyme which participates in decarboxylation of α-keto acids. Dehydrogenation and decarboxylation must precede the formation of “active acetate” in the initial reaction of the TCA cycle (citric acid cycle):
reaction of Thiamine chloride
This reaction is a good example of the interrelationship of vitamin B coenzymes. Four vitamin coenzymes are necessary for this one reaction: (1) thiamine (in TPP) for decarboxylation; (2) nicotinic acid in nicotinamide adenine dinucleotide (NAD); (3) riboflavin in flavin adenine dinucleotide (FAD); and (4) pantothenic acid in coenzyme A (CoA) for activation of the acetate fragment.

Clinical Use

Thiamine chloride, as the base or as the hydrochloride salt, is indicatedin the treatment or prophylaxis of known or suspected thiaminedeficiencies. Severe thiamine deficiency is calledberiberi, which is very rare in developed countries. The mostlikely cause of thiamine deficiency in the United States is theresult of chronic alcoholism, which leads to multiple vitamindeficiencies as a result of poor dietary intake. The major organsaffected are the nervous system (dry beriberi), whichmanifests as neurological damage, the cardiovascular system(wet beriberi), which manifests as heart failure and edema, andthe gastrointestinal tract. Thiamine administration reverses thegastrointestinal, cardiovascular, and neurological symptoms;however, if the deficiency has been severe or of prolonged duration, the neurological damage may be permanent.

Safety Profile

Poison by subcutaneous and intravenous routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NOx, SOx, and Cl-.

Thiamine chloride synthesis

67-03-8
59-43-8
Synthesis of Thiamine chloride from Thiamine hydrochloride

Thiamine chloride Preparation Products And Raw materials

Raw materials

Ethanol Ethyl formate Hydrogen peroxide Chlorosulfonic acid 2-Acetylbutyrolactone
Acrylonitrile Dimethyl sulfate

1of2

Preparation Products

Sulfadiazine 5-Pyrimidinecarboxaldehyde, 4-amino-2-methyl- (6CI,7CI,8CI,9CI) 2-Methyltetrahydrofuran-3-one Furfural 5-(2-Hydroxyethyl)-4-methylthiazole
Thiamine thiocyanate

1of2

Thiamine chloride Suppliers

Global( 567)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei chuangzhiyuan biotechnology co., LTD 13012111162 2792365312@qq.com China 919 58
Zhengzhou Yuhe Food Additive Co. LTD 13838386843 13838386843 2922109373@qq.com China 446 58
inhua City Baikang Biological Engineering Co., LTD 0573-15557365800 15557365800 78117547@qq.com China 509 58
Hebei Jijie Biotechnology Co., Ltd 15803101794 740313571@qq.com China 607 58
Shandong Aicai Biotechnology Co. , Ltd. 13573016375 13573016375 3358761976@qq.com China 585 58
Shanghai Boyle Chemical Co., Ltd. 021-50182298 021-50180596 sales@boylechem.com China 2202 55
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
XiaoGan ShenYuan ChemPharm co,ltd 15527621225; 15527621225 1791901229@qq.com China 6746 52
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
Supplier Advantage
Hebei chuangzhiyuan biotechnology co., LTD 58
Zhengzhou Yuhe Food Additive Co. LTD 58
inhua City Baikang Biological Engineering Co., LTD 58
Hebei Jijie Biotechnology Co., Ltd 58
Shandong Aicai Biotechnology Co. , Ltd. 58
Shanghai Boyle Chemical Co., Ltd. 55
Beijing HwrkChemical Technology Co., Ltd 55
Beijing Ouhe Technology Co., Ltd 60
XiaoGan ShenYuan ChemPharm co,ltd 52
Shandong Xiya Chemical Co., Ltd 57

View Lastest Price from Thiamine chloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Thiamine chloride pictures 2026-09-13 Thiamine chloride
59-43-8
 0.99 RongNa Biotechnology Co.,Ltd
Thiamine chloride Vitamin B1 pictures 2026-09-01 Thiamine chloride Vitamin B1
59-43-8
 1KG 99% 2000KG Shaanxi TNJONE Pharmaceutical Co., Ltd
Thiamine chloride pictures 2026-09-01 Thiamine chloride
59-43-8
 1kg 99% 20tons Shaanxi TNJONE Pharmaceutical Co., Ltd

Thiamine chloride Spectrum

Thiamine chloride(59-43-8)1HNMR

59-43-8(Thiamine chloride)Related Search:

Ammonium chloride Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) Methylparaben Thiamine hydrochloride 3-Diethylaminophenol
Vitamin B12 DL-α-Tocopherol Pyridoxine hydrochloride Riboflavin 5'-Monophosphate Sodium Salt Sodium chloride
Benfotiamine Folic acid Riboflavin Thiophanate-methyl Vitamin A
Vitamin D3 Potassium chloride Menadione Vitamin B1

1of4

THIAMIMEMONOCHLORIDE VITAMIN B1(THIAMINE)(BASF)(SH) VITAMIN B1(THIAMINE)(SH) Antiberiberi factor Betamin Beta-Sol Biamine Metatone Vitamin B1 Thiazolium, 3-(4-amino-2-methyl-5-pyrimidinyl)methyl-5-(2-hydroxyethyl)-4-methyl- chloride 2-[3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-1-thia-3-azoniacyclopenta-2,4-dien-5-yl]ethanol thiamine(1+) chloride Thiamine VB weissb1 THIAMINB-1 Thiamine (unspecified salts) 3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2- hydroxyethyl)-4-methylthiazolium chloride Thiamine chloride VITAMIN B1(MONO HCL: USP) (THIAMINE HCL) Vitamin B1 Mononitrate (Mono) Thiacoat Vitaneurin Vb1 VitaMin 3-((4-aMino-2-MethylpyriMidin-5-yl)Methyl)-5-(2-hydroxyethyl)-4-Methylthiazol-3-iuM chloride 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methylthiazoli aneurine apatatedrape b-amin beivon betabion bethiamin hyl-chloride oryzanin oryzanine thiaminemonochloride thiazolium,3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-met ViatmineB1 AURORA KA-7821 2-[3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-thiazol-3-iumyl]ethanol chloride Thiamine Chloride,>98% Thiamine chloride vitamin B1 Thiamine chloride USP/EP/BP Vitamin B1-13C3 7-Dehydro-7α-desthioacetylspironolactone VITAMIN B1 USP38 thiamin Vitamin B1 59-43-8 59-42-8 67-03-8;59-43-8 159-43-8 C12H17ClN4OS C12H18Cl2N4OS C12H17N4OS C12H18ClN4OS vitamin series Nutritional Supplements Vitamin Ingredients