Quin 2-am
- CAS No.
- 83104-85-2
- Chemical Name:
- Quin 2-am
- Synonyms
- Quin 2-am;Quin 2 Am Ester;Acetoxymethyl ester;quin2-acetoxymethylester;Quin-2, AM *CAS 83104-85-2*;QUIN-2 TETRAACETOXYMETHYL ESTER;8-Amino-2-[(2-amino-5-methylphenoxy)-methyl]-6-methoxyquinoline-N,N,N',N'-tetraacetic acid;Tetrakis(acetoxymethyl) 8-amino-2-[(2-amino-5-methylphenoxy)methyl]-6-methoxyquinoline-N,N,N′,N′-tetraacetate;2-[(2-amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n',n'-tetraacetic acid tetrakis(acetoxymethyl ester);2-[(2-amino-5-methylphenoxy)methyl]- 6-methoxy-8-aminoquinoline-n,n,n0,n0-tetraacetic acid Tetrakis(acetoxymethyl Ester)
- CBNumber:
- CB0158606
- Molecular Formula:
- C38H43N3O18
- Molecular Weight:
- 829.76
- MDL Number:
- MFCD00010285
- MOL File:
- 83104-85-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Density | 1.360 |
|---|---|
| Flash point | 113 °C |
| storage temp. | −20°C |
| solubility | DMSO: soluble |
| form | A solid |
| Appearance | Solid Powder |
| λmax | 348 nm |
| Biological Applications | Calcium indicator |
| FDA UNII | 8EF0C5H59D |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H335-H319 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 1-8-10 | |||||||||
| NFPA 704 |
|
Quin 2-am price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 20422 | Quin-2 AM ≥90% | 83104-85-2 | 1mg | $259 | 2026-04-30 | Buy |
| Cayman Chemical | 20422 | Quin-2 AM ≥90% | 83104-85-2 | 500μg | $110 | 2024-03-01 | Buy |
| ChemScene | CS-7702 | Quin-2AM | 83104-85-2 | 1mg | $563 | 2026-06-04 | Buy |
| aablocks | AA01E6DR | Quin-2 AM ≥95% | 83104-85-2 | 1mg | $594 | 2026-05-30 | Buy |
| TRC | Q796703 | Quin2-AM | 83104-85-2 | 1mg | $120 | 2021-12-16 | Buy |
Quin 2-am Chemical Properties, Uses, Production
Description
Quin-2 AM is a cell-permeant acetoxymethyl ester of the high affinity fluorescent calcium indicator quin-2 . As quin-2 AM enters cells, it is hydrolyzed by intracellular esterases to produce quin-2. Quin-2 binds calcium with a Kd value of 115 nM. It displays high selectivity for calcium, as it is not affected by sodium gradients, membrane potential, or intracellular pH. High affinity probes like quin-2 are ideal for monitoring low levels of calcium, as are found in resting cells. Loadings of up to 2 mM quin-2 are without serious toxic effects, so quin-2 may be used to buffer intracellular calcium transients. Excitation and emission maxima for quin-2 are 339 and 492 nm, respectively.
Uses
2-[(2-Amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-N,N,N',N'-tetraacetic acid tetrakis(acetoxymethyl ester)
Uses
Fluorescent probe for measurement of calcium in biological systems and for selected divalent cations.
Uses
Quin 2-AM is a cell permeable fluorescent probe for Ca2+ that gives a large shift in the UV absorption spectrum and a 20-fold increase in fluorescence upon Ca2+ binding.
References
[1] R Y TSIEN T J R T Pozzan. Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator.[J]. Journal of Cell Biology, 1982, 94 2: 325-334. DOI: 10.1083/jcb.94.2.325
[2] A. MINTA R T J Kao. Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores.[J]. The Journal of Biological Chemistry, 1989, 13 1: 8171-8178. DOI: 10.1016/s0021-9258(18)83165-9
Excitation / Emission Maximum
339 nm/492 nm
Quin 2-am Preparation Products And Raw materials
Raw materials
Preparation Products
Quin 2-am Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
| Shanghai kadel chemical technology co., LTD | 021-4007787-550 400-7787-550 | 2850202386@qq.com | China | 10569 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
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