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D-Homoserine

D-Homoserine structure

CAS No.: 6027-21-0

Chemical Name:: D-Homoserine

Synonyms: H-D-HSE-OH;D-Homoserin;D-HOMOSERINE;H-D-HOSER-OH;(R) HOMOSERINE;H-D-Homoser-OH;D-Beta-Homo-Ser;D-Homoserine>D-Homoserine,97%;dextro-homoserine

CBNumber:: CB0168533

Molecular Formula:: C4H9NO3

Molecular Weight:: 119.12

MDL Number:: MFCD00077786

MOL File:: 6027-21-0.mol

MSDS File:: SDS

Last updated:2026-01-13 11:12:08

Product description	Number	Pack Size	Price
D-Homoserine	H4021	250mg	$96
D-Homoserine	H4021	1g	$667
D-Homoserine >96.0%(T)	H1224	1g	$86
D-Homoserine >96.0%(T)	H1224	5g	$254
D-Homoserine	H615123	250mg	$55
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D-Homoserine Properties

Melting point	205 °C (dec.) (lit.)
alpha	9 º ((c=5, H2O))
Boiling point	368.7±32.0 °C(Predicted)
Density	1.312±0.06 g/cm3(Predicted)
refractive index	8.0 ° (C=2, H2O)
storage temp.	Sealed in dry,Room Temperature
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka	2.21±0.10(Predicted)
form	powder to crystal
color	White to Orange to Green
Water Solubility	Soluble
BRN	1721680
InChI	InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m1/s1
InChIKey	UKAUYVFTDYCKQA-GSVOUGTGSA-N
SMILES	C(O)(=O)[C@@H](CCO)N
LogP	-1.289 (est)
CAS DataBase Reference	6027-21-0(CAS DataBase Reference)
FDA UNII	5VK5MQ3TVS
UNSPSC Code	12352209
NACRES	NA.26

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H319-H335-H315
Precautionary statements	P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
Safety Statements	22-24/25
WGK Germany	3
F	10
HS Code	29225090
Storage Class	11 - Combustible Solids

D-Homoserine price More Price(31)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	H4021	D-Homoserine	6027-21-0	250mg	$96	2025-07-31	Buy
Sigma-Aldrich	H4021	D-Homoserine	6027-21-0	1g	$667	2025-07-31	Buy
TCI Chemical	H1224	D-Homoserine >96.0%(T)	6027-21-0	1g	$86	2025-07-31	Buy
TCI Chemical	H1224	D-Homoserine >96.0%(T)	6027-21-0	5g	$254	2025-07-31	Buy
TRC	H615123	D-Homoserine	6027-21-0	250mg	$55	2021-12-16	Buy

Product number	Packaging	Price	Buy
H4021	250mg	$96	Buy
H4021	1g	$667	Buy
H1224	1g	$86	Buy
H1224	5g	$254	Buy
H615123	250mg	$55	Buy

D-Homoserine Chemical Properties,Uses,Production

Chemical Properties

White to lightbyellow crystalline powder

Uses

peptide synthesis

Definition

ChEBI: The D-enantiomer of homoserine.

Biochem/physiol Actions

D-Homoserine is used for the synthesis of bacterial polysaccharids such as the O-antigen of Acinetobacter lwoffii EK30A. D-Homoserine is used to produce atypical serine protease(s) for mechanism studies.

Synthesis

348-67-4

6027-21-0

The general procedure for the synthesis of D-homoserine from D-methionine was as follows: D-methionine (1) (25.0 g, 167.5 mmol, 1 eq.) was suspended in a mixed H2O/MeOH solvent (466 mL/66 mL) according to the literature method, followed by the addition of methyl iodide (25.2 mL, 405.4 mmol, 2.4 eq.). The resulting suspension was stirred vigorously at room temperature for 48 hours. Upon completion of the reaction, the volume of the reaction mixture was concentrated to one-third of the original volume by vacuum evaporation, while the excess methyl iodide was removed. To the remaining reaction mixture was added water (155 mL) followed by NaHCO3 (14.07 g, 167.5 mmol, 1 equiv). The resulting solution was refluxed for 15 hours and then cooled to room temperature. The solvent was removed under vacuum to give a thick syrupy substance. The syrupy substance was dissolved in water (45 mL) under heating, followed by sequential addition of acetone (90 mL) and ethanol (1000 mL), and a white solid precipitate was observed. The precipitate was filtered and dried under vacuum to give a white solid of the target product D-homoserine (2). Yield: 9.9 g (83 mmol, 50% yield). Melting point: 202°C. 1H NMR (300 MHz, D2O): δ = 1.92-1.78 (m, 1H, 3-CH), 2.09-2.92 (m, 1H, 3-CH), 3.65-3.58 (m, 2H, 4-CH2), 3.68 (dd, 3JH,H = 4.8, 3JH,H = 7.5 Hz, 1H, 2-CH ).13C NMR (75 MHz, D2O): δ = 32.1 (s, 3-C), 53.3 (s, 2-C), 58.5 (s, 4-C), 174.5 (s, 1-C).HRMS (ESI+, MeOH): m/z = 142.0468 [M + Na]+ with a calculated value of 142.0475 for C4H9NO3Na.

References

[1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 19, p. 5168 - 5181
[2] Tetrahedron, 1988, vol. 44, # 2, p. 637 - 642

D-Homoserine Preparation Products And Raw materials

Raw materials

D-fucosylamine D-Galactose D-Methionine Methanol Iodomethane

Water

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Preparation Products

D-Homoserine, N-[(1,1-dimethylethoxy)carbonyl]- (9CI)

D-Homoserine Suppliers

Global( 264)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8749	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
AB PharmaTech,LLC	323-480-4688	sales@acrospharmatech.com	United States	989	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29830	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
AB PharmaTech,LLC	55
career henan chemical co	58
Accela ChemBio Inc.	58
BOC Sciences	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
SIMAGCHEM CORP	58
Hefei TNJ Chemical Industry Co.,Ltd.	58

View Lastest Price from D-Homoserine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-13	D-Homoserine 6027-21-0	US $0.00 / KG	1KG	98.0%	5000kg/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-03-06	D-Homoserine 6027-21-0	US $9.90 / KG	1KG	99%	5tons	Hebei Chuanghai Biotechnology Co., Ltd
2025-05-26	D-Homoserine 6027-21-0	US $6.00 / kg	1kg	0.99	10000	Hebei Fengjia New Material Co., Ltd

D-Homoserine
6027-21-0
US $0.00 / KG
98.0%
WUHAN FORTUNA CHEMICAL CO., LTD

D-Homoserine
6027-21-0
US $9.90 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

D-Homoserine
6027-21-0
US $6.00 / kg
0.99
Hebei Fengjia New Material Co., Ltd

D-Homoserine Spectrum

D-Homoserine(6027-21-0)¹HNMR D-Homoserine(6027-21-0)Raman D-Homoserine(6027-21-0)IR

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D-HOMOSERINE, 98% (97% EE/GLC) Boc-(S)-Homoserine (R) HOMOSERINE (R)-(+)-2-AMINO-4-HYDROXYBUTYRIC ACID (R)-2-AMINO-4-HYDROXYBUTYRIC ACID D-2-Amino-4-hydroxybutanoic acid D-2-AMINO-4-HYDROXYBUTYRIC ACID D-HOMOSERINE H-D-HSE-OH H-D-HOSER-OH H-D-Β-HOSER-OH ;D-Β-HOMOSERINE (R)-2-aMino-4-hydroxybutanoic acid D-Homoserine, (R)-2-Amino-4-hydroxybutyric acid D-Homoserine,97% D-Beta-Homo-Ser D-Homoserine Vetec(TM) reagent grade, 98% H-D-Homoser-OH D-HOMOSERINE, VETEC D-Homoserine≥ 99% (TLC) (2R)-2-amino-4-hydroxybutanoic acid D-Homoserine, 96%, for bio D-Homoserine> D-Homoserine USP/EP/BP dextro-homoserine (2R)-2-azaniumyl-4-hydroxybutanoate D-Homoserin D-Homoserine (9CI, ACI) D-Homoserine H-D-HSer-OH, D-Hse, D-HoSer 6027-21-0 6027-15-1 6067-21-0 121-08-0 Homo-Amino Acids Peptide Synthesis Specialty Synthesis Unnatural Amino Acid Derivatives amino acids Pyridines