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2-HYDROXY-3-NITROACETOPHENONE

2-HYDROXY-3-NITROACETOPHENONE structure

CAS No.: 28177-69-7

Chemical Name:: 2-HYDROXY-3-NITROACETOPHENONE

Synonyms: 2-HYDROXY-3-NITROACETOPHENONE;2’-hydroxy-3-nltroacetophenone;2’-Hydroxy-3’-nitroacetophenone;1-(2-HYDROXY-3-NITRO-PHENYL)-ETHANONE;Ethanone, 1-(2-hydroxy-3-nitrophenyl)-;1-(2-hydroxy-3-nitrophenyl)ethan-1-one;2-hydroxy-1-(3-nitrophenyl)ethan-1-one

CBNumber:: CB0186207

Molecular Formula:: C8H7NO4

Molecular Weight:: 181.15

MDL Number:: MFCD02683784

MOL File:: 28177-69-7.mol

MSDS File:: SDS

Last updated:2026-05-27 17:21:24

Product description	Number	Pack Size	Price
2-HYDROXY-3-NITROACETOPHENONE 97%	55014	1G	$55
2-HYDROXY-3-NITROACETOPHENONE 97%	55014	5G	$149
2-HYDROXY-3-NITROACETOPHENONE 97%	55014	25G	$535
1-(2-Hydroxy-3-nitrophenyl)ethanone 98%	H48520	1g	$25
1-(2-Hydroxy-3-nitrophenyl)ethanone 98%	H48520	5g	$31
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2-HYDROXY-3-NITROACETOPHENONE Properties

Melting point	98.5-99.5 °C
Boiling point	223.5±20.0 °C(Predicted)
Density	1.380±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	7.31±0.24(Predicted)
Appearance	Yellow to brown Solid
InChI	InChI=1S/C8H7NO4/c1-5(10)6-3-2-4-7(8(6)11)9(12)13/h2-4,11H,1H3
InChIKey	XQZGSPSZLMKODN-UHFFFAOYSA-N
SMILES	C(=O)(C1=CC=CC([N+]([O-])=O)=C1O)C
CAS DataBase Reference	28177-69-7(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319
Precautionary statements	P261-P305+P351+P338

2-HYDROXY-3-NITROACETOPHENONE price More Price(33)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
AstaTech	55014	2-HYDROXY-3-NITROACETOPHENONE 97%	28177-69-7	1G	$55	2026-04-30	Buy
AstaTech	55014	2-HYDROXY-3-NITROACETOPHENONE 97%	28177-69-7	5G	$149	2026-04-30	Buy
AstaTech	55014	2-HYDROXY-3-NITROACETOPHENONE 97%	28177-69-7	25G	$535	2026-04-30	Buy
Synthonix	H48520	1-(2-Hydroxy-3-nitrophenyl)ethanone 98%	28177-69-7	1g	$25	2026-05-06	Buy
Synthonix	H48520	1-(2-Hydroxy-3-nitrophenyl)ethanone 98%	28177-69-7	5g	$31	2026-05-06	Buy

Product number	Packaging	Price	Buy
55014	1G	$55	Buy
55014	5G	$149	Buy
55014	25G	$535	Buy
H48520	1g	$25	Buy
H48520	5g	$31	Buy

2-HYDROXY-3-NITROACETOPHENONE Chemical Properties,Uses,Production

Preparation

Preparation by reaction of boiling 5% aqueous potassium hydroxide on 8-nitrochromone (78%).

Synthesis

118-93-4

1450-76-6

28177-69-7

General procedure for the synthesis of 2-hydroxy-5-nitroacetophenone and 2-hydroxy-3-nitroacetophenone from 2'-hydroxyacetophenone: In a four-necked flask, 2'-hydroxyacetophenone (175 g), acetic acid (183 g), and dichloromethane (800 mL) were added sequentially, and the mixture was heated to 40 °C. Subsequently, 63% concentrated nitric acid (165 g) was slowly added dropwise, and the reaction temperature was controlled to be maintained at 40 °C for 4-6 hours. After completion of the dropwise addition, the reaction was continued at 40 °C for 4-6 hours. At the end of the reaction, water (500 g) was added and stirred for 30 minutes for extraction and layering. The organic layer was concentrated to about 200 g of crude product. The above crude product (200 g) was added to a four-necked flask with toluene (900 g), heated to 60-70 °C and reacted at 70-80 °C for 2-4 hours. The reaction mixture was cooled to 30-50 °C and filtered and the filter cake was dried. The dried filter cake was transferred to a four-necked flask, methanol (100 g) and water (800 g) were added and heated to 50-60°C. The reaction mixture was cooled to 30-50°C and filtered. Acetic acid (150 g) was added slowly dropwise and controlled to be added dropwise within 2 hours at 60-70 °C. The reaction mixture was cooled to room temperature and filtered, and the filter cake was dried to give the product A-2 (80 g).

References

[1] Journal of Medicinal Chemistry, 1994, vol. 37, # 20, p. 3353 - 3362
[2] Asian Journal of Chemistry, 2015, vol. 27, # 6, p. 2117 - 2124
[3] Patent: WO2009/85256, 2009, A1. Location in patent: Page/Page column 55
[4] Patent: CN103980257, 2016, B. Location in patent: Paragraph 0033; 0034; 0035

2-HYDROXY-3-NITROACETOPHENONE Preparation Products And Raw materials

Raw materials

2'-Hydroxyacetophenone Nitric acid Dichloromethane

Preparation Products

2-HYDROXY-3-NITROACETOPHENONE Suppliers

Global( 120)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
RongNa Biotechnology Co.,Ltd	+86-86-13583358881 +8618560316533	Brad@rongnabiotech.com	China	3366	58
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29640	60
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52705	58
Henan Alfa Chemical Co., Ltd	+8615838112936	sale03@alfachem.cn	China	9798	58
Aromsyn Co., Ltd.	+86-0571-85585865 +8613336024896	CB@aromsyn.com	China	19183	58

Supplier	Advantage
RongNa Biotechnology Co.,Ltd	58
Capot Chemical Co.,Ltd.	60
Jinan Carbotang Biotech Co.,Ltd.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Henan Alfa Chemical Co., Ltd	58
Aromsyn Co., Ltd.	58

View Lastest Price from 2-HYDROXY-3-NITROACETOPHENONE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-31	2-HYDROXY-3-NITROACETOPHENONE 28177-69-7	$10.00	1ASSAYS	99%	1 ton	RongNa Biotechnology Co.,Ltd
2025-12-01	2-HYDROXY-3-NITROACETOPHENONE 28177-69-7		1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2021-08-12	2-HYDROXY-3-NITROACETOPHENONE 28177-69-7	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd

2-HYDROXY-3-NITROACETOPHENONE
28177-69-7
$10.00
99%
RongNa Biotechnology Co.,Ltd

2-HYDROXY-3-NITROACETOPHENONE
28177-69-7
98.0%
Shaanxi Dideu New Materials Co. Ltd

2-HYDROXY-3-NITROACETOPHENONE
28177-69-7
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

2-HYDROXY-3-NITROACETOPHENONE Spectrum

2-HYDROXY-3-NITROACETOPHENONE(28177-69-7)¹HNMR

28177-69-7(2-HYDROXY-3-NITROACETOPHENONE)Related Search:

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2-BROMO-4'-HYDROXY-3'-NITROACETOPHENONE 1-(2-HYDROXY-5-METHYL-3-NITROPHENYL)PROPAN-1-ONE 5'-FLUORO-2'-HYDROXY-3'-NITRO- 5'-CHLORO-2'-HYDROXY-4'-METHYL-3'-NITROACETOPHENONE 6-FLUORO-8-NITROCHROMONE-3-CARBOXALDEHY&

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5'-ETHYL-2'-HYDROXY-3'-NITROACETOPHENONE 5'-BROMO-2'-HYDROXY-3'-NITROPROPIOPHENONE 4'-HYDROXY-2'-NITROACETOPHENONE

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1-(2-HYDROXY-3-NITRO-PHENYL)-ETHANONE 2-HYDROXY-3-NITROACETOPHENONE 2’-hydroxy-3-nltroacetophenone 2-hydroxy-1-(3-nitrophenyl)ethan-1-one 1-(2-hydroxy-3-nitrophenyl)ethan-1-one Ethanone, 1-(2-hydroxy-3-nitrophenyl)- 2’-Hydroxy-3’-nitroacetophenone 28177-69-7 28177-59-7 Aromatic Acetophenones & Derivatives (substituted)