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4-[(Methylamino)methyl]piperidine-1-carboxylic acid tert-butyl ester

4-[(Methylamino)methyl]piperidine-1-carboxylic acid tert-butyl ester Structure
4-[(Methylamino)methyl]piperidine-1-carboxylic acid tert-butyl ester structure
CAS No.
138022-02-3
Chemical Name:
4-[(Methylamino)methyl]piperidine-1-carboxylic acid tert-butyl ester
Synonyms
1-Boc-4-[(Methylamino)methyl]piperidine;1-N-BOC-4-[(METHYLAMINO)METHYL]PIPERIDINE;tert-butyl 4-((MethylaMino)Methyl)piperidin-1-carboxylate;TERT-BUTYL 4-[(METHYLAMINO)METHYL]PIPERIDINE-1-CARBOXYLATE;1-piperidinecarboxylic acid, 4-[(methylamino)methyl]-, 1,1;tert-Butyl 4-[(methylamino)methyl]-1-piperidinecarboxylate;tert-butyl 2-methyl-4-(methylamino)piperidine-1-carboxylate;1,1-Dimethylethyl 4-[(methylamino)methyl]-1-piperidinecarboxylate;4-(methylaminomethyl)-1-piperidinecarboxylic acid tert-butyl ester;4-[(Methylamino)methyl]piperidine-1-carboxylic acid tert-butyl ester
CBNumber:
CB0204152
Molecular Formula:
C12H24N2O2
Molecular Weight:
228.33
MDL Number:
MFCD06656629
MOL File:
138022-02-3.mol
MSDS File:
SDS
Last updated:2026-09-12 18:47:38
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4-[(Methylamino)methyl]piperidine-1-carboxylic acid tert-butyl ester Properties

Boiling point 301.0±15.0 °C(Predicted)
Density 0.988
storage temp. 2-8°C(protect from light)
pka 10.41±0.10(Predicted)
Appearance Colorless to light yellow Liquid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338
Risk Statements  36737/38
Safety Statements  26-36
HS Code  29333990

4-[(Methylamino)methyl]piperidine-1-carboxylic acid tert-butyl ester price More Price(49)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR321451 tert-Butyl 4-((methylamino)methyl)piperidine-1-carboxylate >98% 138022-02-3 1g $21 2026-06-04 Buy
Apolloscientific OR321451 tert-Butyl 4-((methylamino)methyl)piperidine-1-carboxylate >98% 138022-02-3 5g $51 2026-06-04 Buy
Apolloscientific OR321451 tert-Butyl 4-((methylamino)methyl)piperidine-1-carboxylate >98% 138022-02-3 25g $166 2026-06-04 Buy
Apolloscientific OR321451 tert-Butyl 4-((methylamino)methyl)piperidine-1-carboxylate >98% 138022-02-3 100g $644 2026-06-04 Buy
Synthonix B56336 tert-Butyl 4-((methylamino)methyl)piperidine-1-carboxylate 95+% 138022-02-3 1g $35 2026-05-06 Buy
Product number Packaging Price Buy
OR321451 1g $21 Buy
OR321451 5g $51 Buy
OR321451 25g $166 Buy
OR321451 100g $644 Buy
B56336 1g $35 Buy

4-[(Methylamino)methyl]piperidine-1-carboxylic acid tert-butyl ester Chemical Properties,Uses,Production

Chemical Properties

Colorless liquid

Synthesis

1-TERT-BUTOXYCARBONYLPIPERIDINE-4-CARBOXYLIC ACIDMETHYL AMIDE

544696-01-7

4-[(METHYLAMINO)METHYL]PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

138022-02-3

General procedure for the synthesis of tert-butyl 4-[(methylamino)methyl]piperidine-1-carboxylate from 1-Boc-4-piperidinyl-N-methylamide: 5.76 g (16.64 mmol) of tert-butyl 4-methylcarbamoyl-piperidine-1-carboxylate was dissolved in 60 mL of anhydrous THF. The solution was slowly added to a 60 mL THF suspension containing 1.4 g (37 mmol) of sodium borohydride at 0 °C and stirred for 30 min. Subsequently, 4.2 g (16.54 mmol) of iodine was added to the 60 mL THF solution. The reaction mixture was heated to reflux and maintained for 18 hours. After completion of the reaction, the mixture was cooled to room temperature and 150 mL of methanol was added slowly and dropwise. The reaction mixture was concentrated and sodium hydroxide solution was added. The reaction mixture was extracted with tert-butyl methyl ether. The organic phases were combined and dried over anhydrous sodium sulfate. A final product of 5 g was obtained in 60% yield of the theoretical value and EI mass spectrum showed m/z = 229 [M + H]+.

References

[1] Patent: WO2008/71646, 2008, A1. Location in patent: Page/Page column 80
[2] Patent: WO2005/7658, 2005, A2. Location in patent: Page 230

4-[(Methylamino)methyl]piperidine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

1-tert-Butoxycarbonylpiperidine-4-carboxylic acidmethyl amide Tetrahydrofuran iodine Sodium borohydride Sodium hydroxide

Preparation Products

4-[(Methylamino)methyl]piperidine-1-carboxylic acid tert-butyl ester Suppliers

Global( 101)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Sichuan Guanghan Bio-Tech Co., Ltd +86-28-86127071 info@sino-produce.com China 400 66
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Santai Labs, Inc. 519-85601385 marketing@santailabs.com China 891 62
Shanghai AmasPharm Co., Ltd. 021-54540637 18621091017 sales@amaspharm.com China 787 62
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Capot Chemical Co., Ltd 66
Sichuan Guanghan Bio-Tech Co., Ltd 66
Pure Chemistry Scientific Inc. 62
Accela ChemBio Co.,Ltd. 64
Nanjing Chemlin Chemical Co., Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Santai Labs, Inc. 62
Shanghai AmasPharm Co., Ltd. 62

View Lastest Price from 4-[(Methylamino)methyl]piperidine-1-carboxylic acid tert-butyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-[(METHYLAMINO)METHYL]PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER pictures 2020-01-05 4-[(METHYLAMINO)METHYL]PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
138022-02-3
 $9.80 1g ≥99% 100kg Career Henan Chemical Co

4-[(Methylamino)methyl]piperidine-1-carboxylic acid tert-butyl ester Spectrum

4-[(METHYLAMINO)METHYL]PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(138022-02-3)1HNMR

138022-02-3(4-[(Methylamino)methyl]piperidine-1-carboxylic acid tert-butyl ester)Related Search:

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TERT-BUTYL 4-[(METHYLAMINO)METHYL]PIPERIDINE-1-CARBOXYLATE 1-N-BOC-4-[(METHYLAMINO)METHYL]PIPERIDINE 1-Piperidinecarboxylic acid, 4-[(methylamino)methyl]-, 1,1-dimethylethyl ester 1-piperidinecarboxylic acid, 4-[(methylamino)methyl]-, 1,1 tert-butyl 4-[(methylamino)methyl]piperidine-1-carboxylate - oxalate (2:1) 1-Boc-4-[(Methylamino)methyl]piperidine tert-butyl 4-[(methylamino)methyl]-1-piperidinecarboxylate(SALTDATA: FREE) 4-[(Methylamino)methyl]-1-piperidinecarboxylicacid 1,1-dimethylethyl ester tert-butyl 4-((MethylaMino)Methyl)piperidin-1-carboxylate 4-(methylaminomethyl)-1-piperidinecarboxylic acid tert-butyl ester tert-butyl 2-methyl-4-(methylamino)piperidine-1-carboxylate TIANFU CHEM---4-[(METHYLAMINO)METHYL]PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1,1-Dimethylethyl 4-[(methylamino)methyl]-1-piperidinecarboxylate tert-Butyl 4-[(methylamino)methyl]-1-piperidinecarboxylate 4-[(Methylamino)methyl]piperidine-1-carboxylic acid tert-butyl ester 138022-02-3 Aminomethyl's Pyrans, Piperidines &Piperazines Pyrans, Piperidines & Piperazines