3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE
- CAS No.
- 130336-16-2
- Chemical Name:
- 3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE
- Synonyms
- 1-(3,5-dichlorophenyl)-2,2,2-trifluoroethan-1-one;1-(3,5-DICHLORO-PHENYL)-2,2,2-TRIFLUORO-ETHANONE;uoroethanone;1-(3,5-DichL;5-DICHLORO-2;)-2,2,2-trifL;Fluralaner-002;Fluralaner Impurity 28;2-TRIFLUOROACETOPHENONE;3,5-Dichloro-2,2,2-trifluorophenone
- CBNumber:
- CB0206550
- Molecular Formula:
- C8H3Cl2F3O
- Molecular Weight:
- 243.01
- MDL Number:
- MFCD01319996
- MOL File:
- 130336-16-2.mol
| Boiling point | 265℃ |
|---|---|
| Density | 1.506 |
| refractive index | 1.4980 to 1.5020 |
| Flash point | 114℃ |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly) |
| form | Oil |
| color | Colourless |
| InChI | InChI=1S/C8H3Cl2F3O/c9-5-1-4(2-6(10)3-5)7(14)8(11,12)13/h1-3H |
| InChIKey | DZDSQRPDUCSOQV-UHFFFAOYSA-N |
| SMILES | C(=O)(C1=CC(Cl)=CC(Cl)=C1)C(F)(F)F |
| CAS DataBase Reference | 130336-16-2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| HS Code | 2914790090 | |||||||||
| NFPA 704 |
|
3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D5113 | 3',5'-Dichloro-2,2,2-trifluoroacetophenone >96.0%(GC) | 130336-16-2 | 1g | $43 | 2025-07-31 | Buy |
| TCI Chemical | D5113 | 3',5'-Dichloro-2,2,2-trifluoroacetophenone >96.0%(GC) | 130336-16-2 | 5g | $169 | 2025-07-31 | Buy |
| TRC | D436405 | 3'',5''-Dichloro-2,2,2-trifluoroacetophenone | 130336-16-2 | 25g | $730 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0012118 | 3',5'-DICHLORO-2,2,2-TRIFLUORO ACETOPHENONE 95.00% | 130336-16-2 | 1G | $818.61 | 2021-12-16 | Buy |
| Rieke Metals | 6518-2 | 3',5'-Dichloro-2,2,2-trifluoroacetophenone 97% | 130336-16-2 | 5g | $1059 | 2021-12-16 | Buy |
3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE Chemical Properties,Uses,Production
Uses
3'',5''-Dichloro-2,2,2-trifluoroacetophenone is a reagent used for enantioselective preparation of benzazephinoindoles bearing trifluoromethylated quaternary stereocenters catalyzed by chiral spirocyclic phosphoric acids
Synthesis
19752-55-7
407-25-0
130336-16-2
Under nitrogen protection, tert-butyllithium (1.3 M in pentane, 17.8 mL, 23.2 mmol) was slowly added dropwise to a solution of 3,5-dichloro-1-bromobenzene (5.0 g, 22.1 mmol) in tetrahydrofuran (50 mL) over a period of 30 min, followed by continuing the reaction for 2 h at -78 °C. Upon completion of the reaction, trifluoroacetic anhydride (2.56 g, 12.2 mmol) was slowly added dropwise to the reaction mixture and stirring was continued for 2 hours at -78 °C. The cooling bath was removed and the reaction mixture was allowed to warm slowly to room temperature and stirring was continued at room temperature for 2.5 hours. When the reaction was terminated, saturated ammonium chloride solution (50 mL) was added. The reaction mixture was extracted with ether (3 x 50 mL) and the organic phases were combined and washed with saturated brine (20 mL x 2). The organic phase was separated, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure, and purified by distillation under reduced pressure to give the colorless transparent liquid 3',5'-dichloro-2,2,2-trifluoroacetophenone (2.58 g, 48% yield).
References
[1] Patent: CN107353189, 2017, A. Location in patent: Paragraph 0019; 0023
[2] Bulletin of the Chemical Society of Japan, 1997, vol. 70, # 12, p. 3081 - 3090
3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Mayue Longteng Technology Development Co., Ltd. | +undefined15171477138 | helen.yan@lantu-tech.com | China | 297 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9984 | 58 |
| SHANGHAI FLUORORING PHARMACEUTICAL CO LTD | 17501600223 | sales@fluororing.com | China | 75 | 58 |
| airuikechemical co., ltd. | +86-18353166132 | sales02@airuikechemical.com | China | 983 | 58 |
| Hebei Junhua Import and Export Co., LTD | +85259680964 | junhua1@hb-junhua.com | China | 933 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29734 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 12938 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21620 | 55 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
View Lastest Price from 3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-23 | 3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE
130336-16-2
|
US $0.00-0.00 / kg | 1kg | 99% | 1000 | Hebei Junhua Import and Export Co., LTD | |
 |
2025-09-22 | 3',5'-Dichloro-2,2,2-trifluoroacetophenone
130336-16-2
|
US $0.00 / kg | 1kg | 99% | 1000kg | Shanghai Joiny Pharmaceutical Co.,LTD | |
 |
2025-07-08 | 1-(3,5-Dichlorophenyl)-2,2,2-trifluoroethanone
130336-16-2
|
US $0.00-0.00 / kg | 1kg | 98.0% min | 1ton/month | Hangzhou ICH Biofarm Co., Ltd |
-
- 3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE
130336-16-2
- US $0.00-0.00 / kg
- 99%
- Hebei Junhua Import and Export Co., LTD
-
- 3',5'-Dichloro-2,2,2-trifluoroacetophenone
130336-16-2
- US $0.00 / kg
- 99%
- Shanghai Joiny Pharmaceutical Co.,LTD
-
- 1-(3,5-Dichlorophenyl)-2,2,2-trifluoroethanone
130336-16-2
- US $0.00-0.00 / kg
- 98.0% min
- Hangzhou ICH Biofarm Co., Ltd
130336-16-2(3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE)Related Search:
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