3-hydroxy-2,2-dimethylpropanenitrile
- CAS No.
- 19295-57-9
- Chemical Name:
- 3-hydroxy-2,2-dimethylpropanenitrile
- Synonyms
- 3-hydroxy-2,2-dimethylpropanenitrile;3-hydroxy-2,2-dimethyl-propionitrile;propanenitrile, 3-hydroxy-2,2-dimethyl-
- CBNumber:
- CB02133418
- Molecular Formula:
- C5H9NO
- Molecular Weight:
- 99.13
- MDL Number:
- MFCD12028479
- MOL File:
- 19295-57-9.mol
| Product description | Number | Pack Size | Price |
| 3-Hydroxy-2,2-dimethylpropanenitrile | H295570 | 50mg | $90 |
| 3-Hydroxy-2,2-dimethylpropanenitrile | H295570 | 100mg | $155 |
| 3-Hydroxy-2,2-dimethylpropanenitrile | 041011 | 500mg | $165 |
| 3-HYDROXY-2,2-DIMETHYLPROPANENITRILE 95.00% | CHM0085746 | 0.5G | $682 |
| 3-HYDROXY-2,2-DIMETHYLPROPANENITRILE 95.00% | CHM0085746 | 1G | $750.75 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H312-H315-H335-H302-H332 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501-P261-P271-P304+P340-P312-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
| HazardClass | IRRITANT |
3-hydroxy-2,2-dimethylpropanenitrile price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | H295570 | 3-Hydroxy-2,2-dimethylpropanenitrile | 19295-57-9 | 50mg | $90 | 2021-12-16 | Buy |
| TRC | H295570 | 3-Hydroxy-2,2-dimethylpropanenitrile | 19295-57-9 | 100mg | $155 | 2021-12-16 | Buy |
| Matrix Scientific | 041011 | 3-Hydroxy-2,2-dimethylpropanenitrile | 19295-57-9 | 500mg | $165 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0085746 | 3-HYDROXY-2,2-DIMETHYLPROPANENITRILE 95.00% | 19295-57-9 | 0.5G | $682 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0085746 | 3-HYDROXY-2,2-DIMETHYLPROPANENITRILE 95.00% | 19295-57-9 | 1G | $750.75 | 2021-12-16 | Buy |
3-hydroxy-2,2-dimethylpropanenitrile Chemical Properties,Uses,Production
Synthesis
1572-98-1
19295-57-9
The general procedure for the synthesis of 3-hydroxy-2,2-dimethylpropionitrile from ethyl 2-cyano-2-methylpropionate was as follows: 1) Dissolve ethyl 2-cyano-2-methylpropionate (5.0 g, 35.4 mmol) in a solvent mixture of tetrahydrofuran (40 mL) and water (100 mL). 2) Sodium borohydride (4.47 g, 106 mmol) was added slowly and the reaction mixture was stirred at room temperature for 3 hours. 3) Upon completion of the reaction, 6N hydrochloric acid was slowly added to the mixture to quench the reaction. 4) The reaction mixture was extracted with ethyl acetate and the organic phases were combined. 5) The organic phase was washed with water, dried over anhydrous magnesium sulfate, filtered and passed through a small amount of silica gel column. 6) The filtrate was concentrated under pressure to give the title compound 3-hydroxy-2,2-dimethylpropionitrile (3.4 g, 97% yield) as an oil. The product was characterized by 1H-NMR (CDCl3): δ 1.36 (6H, s), 3.58 (2H, s).
References
[1] Patent: US2009/156582, 2009, A1. Location in patent: Page/Page column 35
[2] Patent: EP1847531, 2007, A1. Location in patent: Page/Page column 51
[3] Patent: EP1717238, 2006, A1. Location in patent: Page/Page column 61
[4] Patent: WO2017/48675, 2017, A1. Location in patent: Paragraph 0434
[5] Patent: CN106478651, 2017, A. Location in patent: Paragraph 0900; 0901; 0902
3-hydroxy-2,2-dimethylpropanenitrile Preparation Products And Raw materials
Raw materials
Preparation Products
3-hydroxy-2,2-dimethylpropanenitrile Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
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| Nanjing Hengbei Chemicals Co., Ltd. | +86-25-58393656 | sales@hengbeichem.cn | China | 6854 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 24727 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Qingdao Dexin Chemical Co., Ltd | +86-15553333686 | 15553333686@qq.com | China | 3113 | 58 |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323658 +86-18168183658 | sales1@artkmedchem.com | China | 39002 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Chengdu Feibo Pharm Technology Co., Ltd | +86 028-84641798 15982321820 | abby@arkpharm.com | China | 9993 | 58 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
