Chloromethyl isopropyl carbonate
- CAS No.
- 35180-01-9
- Chemical Name:
- Chloromethyl isopropyl carbonate
- Synonyms
- CMIC;Chloromethy Isopropyl carbonate;ALSTint-A08;Chloromethyl isoprop;Tenofovir Impurity 56;Tenofovir CMIC Impurity;Tenofovir Impurity 41 CRS;Tenofovir intermediate(CMIC);L-Propylchloromethylcarbonate;Chloromethyl isopropyl carbote
- CBNumber:
- CB0223267
- Molecular Formula:
- C5H9ClO3
- Molecular Weight:
- 152.58
- MDL Number:
- MFCD07375443
- MOL File:
- 35180-01-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Chloromethyl isopropyl carbonate United States Pharmacopeia (USP) Reference Standard | 1115705 | 100MG | $1460 |
| Chloromethyl Isopropyl Carbonate >98.0%(GC) | C2626 | 25g | $54 |
| Chloromethyl Isopropyl Carbonate >98.0%(GC) | C2626 | 100g | $162 |
| Chloromethyl isopropyl carbonate | 268404 | 5g | $360 |
| Chloromethyl isopropyl carbonate | 268404 | 10g | $489 |
| More product size | |||
| Boiling point | 66 °C(Press: 16 Torr) |
|---|---|
| Density | 1.14 |
| refractive index | 1.4110-1.4150 |
| Flash point | 50° |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Chloroform (Slightly), DMSO, Ethyl Acetate (Slightly) |
| form | clear liquid |
| color | Colorless to Almost colorless |
| Stability | Moisture sensitive |
| Major Application | pharmaceutical (small molecule) |
| InChI | InChI=1S/C5H9ClO3/c1-4(2)9-5(7)8-3-6/h4H,3H2,1-2H3 |
| InChIKey | JHYNXXBAHWPABC-UHFFFAOYSA-N |
| SMILES | C(OC(C)C)(=O)OCCl |
| CAS DataBase Reference | 35180-01-9(CAS DataBase Reference) |
| FDA UNII | 6S8MF45ZHW |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H317-H411 | |||||||||
| Precautionary statements | P280 | |||||||||
| Safety Statements | 24/25 | |||||||||
| RIDADR | 2924 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HazardClass | 3/8 | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 29189900 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Aquatic Chronic 2 Skin Irrit. 2 Skin Sens. 1 |
|||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
Chloromethyl isopropyl carbonate price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 1115705 | Chloromethyl isopropyl carbonate United States Pharmacopeia (USP) Reference Standard | 35180-01-9 | 100MG | $1460 | 2026-04-30 | Buy |
| TCI Chemical | C2626 | Chloromethyl Isopropyl Carbonate >98.0%(GC) | 35180-01-9 | 25g | $54 | 2026-04-30 | Buy |
| TCI Chemical | C2626 | Chloromethyl Isopropyl Carbonate >98.0%(GC) | 35180-01-9 | 100g | $162 | 2026-04-30 | Buy |
| Usbiological | 268404 | Chloromethyl isopropyl carbonate | 35180-01-9 | 5g | $360 | 2026-06-03 | Buy |
| Usbiological | 268404 | Chloromethyl isopropyl carbonate | 35180-01-9 | 10g | $489 | 2026-06-03 | Buy |
Chloromethyl isopropyl carbonate Chemical Properties,Uses,Production
Chemical Properties
Clear Colourless Liquid
Uses
Chloromethyl Isopropyl Carbonate is an antiviral agent and a Tenofovir (T018500) intermediate. Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor used as an anti-HIV agent.
Synthesis
At 0-5°C, a photoinitiator is added, and dimethyl carbonate and chlorine are subjected to light reaction. The reaction is stopped, and the product is distilled and separated to obtain dimethyl monochlorocarbonate. At 70-100°C, a catalyst is added, and dimethyl monochlorocarbonate and isopropanol are added to a distillation tower capable of controlling the reflux ratio. Methanol is distilled and separated under normal pressure while reacting. After the reaction is completed, excess isopropanol is distilled off under reduced pressure, and finally chloromethyl isopropyl carbonate is distilled under reduced pressure.
References
[1] Tetrahedron, 2011, vol. 67, # 29, p. 5319 - 5328
[2] Patent: JP2015/164934, 2015, A. Location in patent: Paragraph 0195
[3] Journal of Medicinal Chemistry, 2009, vol. 52, # 3, p. 771 - 778
[4] Patent: WO2004/92189, 2004, A1. Location in patent: Page 29
[5] Journal of Medicinal Chemistry, 2015, vol. 58, # 23, p. 9133 - 9153
Chloromethyl isopropyl carbonate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiangsu Vcan Advanced Material Co., Ltd. | +86-17306299870 +86-18652789875 | vcanam@vcanam.com | China | 49 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-173 9270 1263 | 1057@dideu.com | China | 3997 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5228 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
| Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 | sales@fine-chemtech.com | CHINA | 885 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 | info@tnjchem.com | China | 2988 | 55 |
View Lastest Price from Chloromethyl isopropyl carbonate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-05 | Chloromethyl isopropyl carbonate
35180-01-9
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-05-28 | Chloromethyl Isopropyl Carbonate
35180-01-9
|
$2.00-5.00 | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2026-05-21 | Chloromethyl isopropyl carbonate
35180-01-9
|
1KG | ≥99% | 200mt/year | Jinan Finer Chemical Co., Ltd |
-
- Chloromethyl isopropyl carbonate
35180-01-9
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Chloromethyl Isopropyl Carbonate
35180-01-9
- $2.00-5.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- Chloromethyl isopropyl carbonate
35180-01-9
- $0.00
- ≥99%
- Jinan Finer Chemical Co., Ltd
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