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2,4-DICHLORO-5-NITROPYRIDINE

2,4-DICHLORO-5-NITROPYRIDINE structure

CAS No.: 4487-56-3

Chemical Name:: 2,4-DICHLORO-5-NITROPYRIDINE

Synonyms: oro-5-nitropyridine;4-DICHLORO-5-NITROPYRIDINE;2,4-DICHLORO-5-NITROPYRIDINE;5-nitro-2,4-dichloro pyridine;2,4-DIHYDROXY-5-NITROPYRIDINE;Pyridine, 2,4-dichloro-5-nitro-;2,4-Dichloro-5-nitropyridine >2,4-Dichloro-5-nitropyridine ,95%;2,4-Dichloro-5-Nitropyridine(WXC02234);4-chloro-5-methyl-3-nitropyridin-2-amine

CBNumber:: CB0231226

Molecular Formula:: C5H2Cl2N2O2

Molecular Weight:: 192.99

MDL Number:: MFCD07368834

MOL File:: 4487-56-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 17:23:41

Product description	Number	Pack Size	Price
2,4-Dichloro-5-nitropyridine >98.0%(GC)	D4752	1g	$97
2,4-Dichloro-5-nitropyridine Asreported	274226	250mg	$347
2,4-Dichloro-5-nitropyridine Asreported	274226	500mg	$475
2,4-Dichloro-5-nitropyridine Asreported	274226	1g	$758
2,4-Dichloro-5-nitropyridine Asreported	274226	2g	$1050
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2,4-DICHLORO-5-NITROPYRIDINE Properties

Melting point	42.0 to 46.0 °C
Boiling point	282.3±35.0 °C(Predicted)
Density	1.629±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	soluble in Methanol
form	powder to crystal
pka	-2.49±0.10(Predicted)
color	Light orange to Yellow to Green
InChI	InChI=1S/C5H2Cl2N2O2/c6-3-1-5(7)8-2-4(3)9(10)11/h1-2H
InChIKey	RZVJQUMDJUUBBF-UHFFFAOYSA-N
SMILES	C1(Cl)=NC=C([N+]([O-])=O)C(Cl)=C1
CAS DataBase Reference	4487-56-3

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H301
Precautionary statements	P301+P310
Hazard Codes	Xi,T
Risk Statements	25
Safety Statements	45
RIDADR	2811
HazardClass	6.1
PackingGroup	Ⅲ
HS Code	2933399990

2,4-DICHLORO-5-NITROPYRIDINE price More Price(74)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	D4752	2,4-Dichloro-5-nitropyridine >98.0%(GC)	4487-56-3	1g	$97	2026-04-30	Buy
Usbiological	274226	2,4-Dichloro-5-nitropyridine Asreported	4487-56-3	250mg	$347	2026-06-03	Buy
Usbiological	274226	2,4-Dichloro-5-nitropyridine Asreported	4487-56-3	500mg	$475	2026-06-03	Buy
Usbiological	274226	2,4-Dichloro-5-nitropyridine Asreported	4487-56-3	1g	$758	2026-06-03	Buy
Usbiological	274226	2,4-Dichloro-5-nitropyridine Asreported	4487-56-3	2g	$1050	2026-06-03	Buy

Product number	Packaging	Price	Buy
D4752	1g	$97	Buy
274226	250mg	$347	Buy
274226	500mg	$475	Buy
274226	1g	$758	Buy
274226	2g	$1050	Buy

2,4-DICHLORO-5-NITROPYRIDINE Chemical Properties,Uses,Production

Chemical Properties

Light yellow needles

Uses

2,4-Dichloro-5-nitropyridine is used in the synthesis of potent and selective stearoyl-CoA desaturase (SCD) inhibitors. Also used in preparation of Rho-Kinase inhibitors displaying antihypertensive activity.

Synthesis

850663-54-6

4487-56-3

Step 3. Synthesis of 2,4-dichloro-5-nitropyridine: The product of step 2, 2-hydroxy-4-chloro-5-nitropyridine (40.0 g, 229 mmol), was suspended in toluene (300 mL), and phosphorus oxychloride (POCl3, 65 mL, 697 mmol) was added dropwise over a period of 10 min. Subsequently, the reaction mixture was heated to reflux and maintained for 6 hours. Upon completion of the reaction, the mixture was cooled to 60 °C and stirred continuously at this temperature overnight. The non-homogeneous reaction mixture was cooled to room temperature and subsequently concentrated under reduced pressure to remove the solvent. The residue was carefully adjusted to an alkaline pH with saturated aqueous potassium carbonate (K2CO3). extraction was carried out with ethyl acetate (EtOAc), the organic phases were combined and washed sequentially with water and saturated brine. The organic layer was dried over anhydrous sodium sulfate (Na2SO4), filtered and the filtrate was concentrated to give the crude product as an oil. Purification by silica gel column chromatography (eluent: hexane solution of 50% ethyl acetate) afforded the title compound 2,4-dichloro-5-nitropyridine (32.5 g, 74% yield) as an orange oil, which solidified to a solid on standing. Mass spectrometry (electrospray positive ion mode, ES+) showed the molecular ion peak m/e 194 [M+H]+.

References

[1] Journal of Medicinal Chemistry, 2007, vol. 50, # 1, p. 2 - 5
[2] Patent: WO2005/37197, 2005, A2. Location in patent: Page/Page column 84
[3] Journal of Heterocyclic Chemistry, 2014, vol. 51, # 2, p. 404 - 410
[4] Patent: EP2818472, 2014, A1. Location in patent: Paragraph 0126; 0128

2,4-DICHLORO-5-NITROPYRIDINE synthesis

Synthesis of 2,4-DICHLORO-5-NITROPYRIDINE from 4,6-DICHLORO-PYRIDIN-3-YLAMINE

2,4-DICHLORO-5-NITROPYRIDINE Preparation Products And Raw materials

Raw materials

Potassium tert-butoxide tert-Butyl hydroperoxide Phosphorus oxitrichloride 4-Hydroxypyridine Tetrahydrofuran

Nitric acid Sulfuric acid 4-Ethoxy-3-nitropyridine 4,6-DICHLORO-PYRIDIN-3-YLAMINE 2-AMINO-4-CHLORO-5-NITROPYRIDINE

4-Chloro-5-nitro-2-hydroxypyridine 4-Chloro-3-nitropyridine 4-Hydroxy-3-nitropyridine

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Preparation Products

2-chloro-5-nitro-4-(propan-2-yloxy)pyridine

2,4-DICHLORO-5-NITROPYRIDINE Suppliers

Global( 335)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20122	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	880	50
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Hi-Tech Chemistry Corp	0519-86626038	yuhh@hitechem.com	CHINA	810	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21587	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
Fluoropharm Co., Ltd.	+86-0571-85586753 +86-13336034509	sales@fluoropharm.com	China	1445	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10403	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58

Supplier	Advantage
Henan Fengda Chemical Co., Ltd	58
Frapp's ChemicalNFTZ Co., Ltd.	50
Capot Chemical Co.,Ltd.	60
Hi-Tech Chemistry Corp	58
Henan Tianfu Chemical Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
Fluoropharm Co., Ltd.	60
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Accela ChemBio Inc.	58

View Lastest Price from 2,4-DICHLORO-5-NITROPYRIDINE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-11-18	2,4-DICHLORO-5-NITROPYRIDINE 4487-56-3	$1.10	1g	99.00%	100 Tons min	Dideu Industries Group Limited
2025-09-25	2,4-Dichloro-5-nitropyridine 4487-56-3	$1.00-200.00	1KG	99%, 99.5% Sublimated		Henan Fengda Chemical Co., Ltd
2025-04-04	2,4-DICHLORO-5-NITROPYRIDINE 4487-56-3		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

2,4-DICHLORO-5-NITROPYRIDINE
4487-56-3
$1.10
99.00%
Dideu Industries Group Limited

2,4-Dichloro-5-nitropyridine
4487-56-3
$1.00-200.00
99%, 99.5% Sublimated
Henan Fengda Chemical Co., Ltd

2,4-DICHLORO-5-NITROPYRIDINE
4487-56-3
98%
Henan Aochuang Chemical Co.,Ltd.

2,4-DICHLORO-5-NITROPYRIDINE Spectrum

2,4-DICHLORO-5-NITROPYRIDINE(4487-56-3)¹HNMR 2,4-DICHLORO-5-NITROPYRIDINE(4487-56-3)FT-IR

4487-56-3(2,4-DICHLORO-5-NITROPYRIDINE)Related Search:

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2,3-DICHLORO-5-NITROPYRIDINE 3,5-DICHLORO-4-NITROPYRIDINE 3-Amino-4-chloropyridine 4,6-DICHLORO-PYRIDIN-3-YLAMINE 2,4-DICHLORO-5-NITROPYRIDINE

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2,4-DICHLORO-5-NITROPYRIDINE 4-chloro-5-methyl-3-nitropyridin-2-amine 2,4-DIHYDROXY-5-NITROPYRIDINE Pyridine, 2,4-dichloro-5-nitro- 2,4-Dichloro-5-nitropyridine ,95% 5-nitro-2,4-dichloro pyridine 2,4-Dichloro-5-Nitropyridine(WXC02234) 2,4-Dichloro-5-nitropyridine > oro-5-nitropyridine 2,4-DICHLORO-5-NITROPYRIDINE ISO 9001：2015 REACH 4-DICHLORO-5-NITROPYRIDINE 4487-56-3