Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>3-Bromo-2,4-dimethylpyridine

3-Bromo-2,4-dimethylpyridine

3-Bromo-2,4-dimethylpyridine Structure
3-Bromo-2,4-dimethylpyridine structure
CAS No.
27063-93-0
Chemical Name:
3-Bromo-2,4-dimethylpyridine
Synonyms
3-BroMo-2,4-lutidine;3-Bromo-2,4-dimethylpyridine;3-Bromo-2,4-Dimethylpiperidine;PYRIDINE, 3-BROMO-2,4-DIMETHYL
CBNumber:
CB02451679
Molecular Formula:
C7H8BrN
Molecular Weight:
186.05
MDL Number:
MFCD09842453
MOL File:
27063-93-0.mol
MSDS File:
SDS
Last updated:2026-09-12 18:48:00
Request For Quotation

3-Bromo-2,4-dimethylpyridine Properties

Boiling point 28-29 °C(Press: 40 Torr)
Density 1.415±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
pka 4.25±0.18(Predicted)
Appearance Off-white to light brown Solid-Liquid Mixture
CAS DataBase Reference 27063-93-0

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338

3-Bromo-2,4-dimethylpyridine price More Price(54)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR938365 3-Bromo-2,4-dimethylpyridine 96% 27063-93-0 100mg $43 2026-06-04 Buy
Apolloscientific OR938365 3-Bromo-2,4-dimethylpyridine 96% 27063-93-0 250mg $51 2026-06-04 Buy
Apolloscientific OR938365 3-Bromo-2,4-dimethylpyridine 96% 27063-93-0 1g $175 2026-06-04 Buy
Apolloscientific OR938365 3-Bromo-2,4-dimethylpyridine 96% 27063-93-0 5g $755 2026-06-04 Buy
Activate Scientific AS36336 3-Bromo-2,4-dimethylpyridine 96% 27063-93-0 1g $218 2026-06-04 Buy
Product number Packaging Price Buy
OR938365 100mg $43 Buy
OR938365 250mg $51 Buy
OR938365 1g $175 Buy
OR938365 5g $755 Buy
AS36336 1g $218 Buy

3-Bromo-2,4-dimethylpyridine Chemical Properties, Uses, Production

Application

3-Bromo-2,4-dimethylpiperidine is a heterocyclic organic compound that can be used as a pharmaceutical intermediate.

Synthesis

2,4-Lutidine

108-47-4

5-BROMO-2,4-DIMETHYLPYRIDINE

27063-92-9

3,5 - DibroMo - 2,4 - diMethylpyridine

29976-20-3

3-BROMO-2,4-DIMETHYLPYRIDINE

27063-93-0

Under stirring, 2,4-dimethylpyridine (5.39 mL, 46.7 mmol, 1 equiv.) was dissolved in bromide (50 mL) containing 20% free SO3, keeping the reaction temperature at 0 °C. An efficient reflux condenser was installed and the reaction mixture was heated to 165 °C in an oil bath. Bromine (4.30 mL, 83.4 mmol, 0.9 eq.) was added slowly in 0.5 mL portions over a period of 5 hours and stirring was continued at 155-175 °C for 20 hours. After completion of the reaction, the solution was cooled to room temperature, poured onto crushed ice (200 g) and stirred for 1 hour. The resulting orange solution was neutralized by careful addition of solid Na2CO3, diluted with water and extracted with EtOAc (2 x 250 mL). The organic layers were combined, dried with Na2SO4 and concentrated in vacuum. The crude product was purified by automated fast column chromatography (Biotage KP-Sil.TM.SNAP 340g column, 0-15% EtOAc/hexane) and dried under vacuum to give three bromo products: 3,5-dibromo-2,4-dimethylpyridine (8), 5-bromo-2,4-dimethylpyridine (9) and 3-bromo-2,4-dimethylpyridine (10). 3,5-Dibromo-2,4-dimethylpyridine (8) is a white solid (1.48 g, 12%) with a melting point of 28-30 °C; 1H NMR (400 MHz, CDCl3) δ 2.54 (s, 3H, CH3), 2.61 (s, 3H, CH3), 8.41 (s, 1H, pyHortho); 13C NMR (100 MHz, CDCl3) δ 23.8 (CH3), 25.7 (CH3), 120.3 (ArC), 124.4 (ArC), 146.4 (ArC), 148.5 (ArCH), 156.5 (ArC); IR νmax (film)/cm1 3045, 2998, 2956, 2921, 1558, 1433, 1376, 1349, 1232, 1376, 1349, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232, 1232 1376, 1349, 1232, 1049, 993, 928, 783; HRMS (ESI+) m/z calcd for C7H8Br2N [M+H]+ 263.9018, found 263.9027. 5-Bromo-2,4-dimethylpyridine (9) was a colorless oil (1.89 g, 22%); 1H NMR (400 MHz, CDCl3) δ 2.32 (s, 3H, CH3), 2.44 (s, 3H, CH3), 7.00 (s, 1H, pyHortho), 8.47 (s, 1H, pyHmeta); 13C NMR ( 100 MHz, CDCl3) δ 22.1 (CH3), 23.6 (CH3), 120.4 (ArC), 125.5 (ArCH), 146.7 (ArC), 150.5 (ArCH), 157.0 (ArC); IR νmax (film)/cm1 2985, 2957, 2924, 2854, 1592, 1461, 1377 1592, 1461, 1377, 1353, 1289, 1177, 1032; HRMS (ESI+) m/z calcd for C7H9BrN [M+H]+ 185.9913, found 185.9918. 3-Bromo-2,4-dimethylpyridine (10) was a colorless oil (3.04 g, 35%); 1H NMR (400 MHz, CDCl3) δ 2.33 (s, 3H, CH3), 2.61 (s, 3H, CH3), 6.91 (d, J = 5.0 Hz, 1H, pyHmeta), 8.18 (d, J = 5.0 Hz, 1H, 2995, 2958, 2922, 1585, 1437, 1389, 1123, 1024, 916, 825; HRMS (ESI+) m/z calcd for C7H9BrN [M+H]+ 185.9913, found 185.9917.

References

[1] Zeitschrift fuer Chemie (Stuttgart, Germany), 1988, vol. 28, # 2, p. 59 - 60
[2] Patent: WO2010/43866, 2010, A2. Location in patent: Page/Page column 48; 87-88
[3] Organic and Biomolecular Chemistry, 2011, vol. 9, # 1, p. 127 - 135

3-Bromo-2,4-dimethylpyridine synthesis

108-47-4
27063-92-9
27063-93-0
Synthesis of 3-Bromo-2,4-dimethylpyridine from 2,4-Lutidine

3-Bromo-2,4-dimethylpyridine Preparation Products And Raw materials

Raw materials

2,4-Lutidine

Preparation Products

5-Bromo-2,4-dimethylpyridine 2,4-diMethyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine

3-Bromo-2,4-dimethylpyridine Suppliers

Global Suppliers ( 99)
Supplier Tel Email Country ProdList Advantage
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Shanghai Raise Chemical Technology Co.,Ltd +86-021-50935922 China 7854 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Modachem Shanghai Co., Ltd +86 (0)21 51320687 51371369 1744605818 China 1576 58
Hunan HuaTeng Pharmaceutical Co., Ltd., 400-8592883 15367835770 sales@huatengsci.com China 5869 58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66028182 17714375163 yftan@aikonchem.com China 16674 50
Shanghai Tombiopharma Chemical Co. Ltd. 13391076197 tombiopharma@163.com China 4986 55
Cool Pharm, Ltd 021-60455363 18019463053 sales@coolpharm.com China 8455 58
Supplier Advantage
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Pure Chemistry Scientific Inc. 62
Shanghai Hanhong Scientific Co.,Ltd. 64
Shanghai Raise Chemical Technology Co.,Ltd 55
Bide Pharmatech Ltd. 60
Modachem Shanghai Co., Ltd 58
Hunan HuaTeng Pharmaceutical Co., Ltd., 58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 50
Shanghai Tombiopharma Chemical Co. Ltd. 55
Cool Pharm, Ltd 58

View Latest Price from 3-Bromo-2,4-dimethylpyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-BROMO-2,4-DIMETHYLPYRIDINE pictures 2019-09-04 3-BROMO-2,4-DIMETHYLPYRIDINE
27063-93-0
 $6.00 2KG 98% 1KG,50KG,100KG Career Henan Chemical Co

3-Bromo-2,4-dimethylpyridine Spectrum

3-BROMO-2,4-DIMETHYLPYRIDINE(27063-93-0)1HNMR

27063-93-0 (3-Bromo-2,4-dimethylpyridine) Related Search:

2,4-Lutidine 2,4-Dimethylpiperidine 3-Bromo-2,4,6-trimethylpyridine 5-Bromo-2-chloro-4,6-dimethylnicotinonitrile 3,5-Dibromo-2,4,6-trimethylpyridine
2-Amino-5-bromo-4 6-dimethylpyridine 2-Amino-3,5-dibromo-4,6-dimethylpyridine 2-Amino-3-nitro-4,6-dimethyl-5-bromopyridine 5-Bromo-2-hydroxy-4,6-dimethyl-nicotinonitrile 5-Bromo-4,6-dimethyl-1H-pyrazolo[3,4-b]pyridin-3-amine
5-Bromo-4,6-dimethylnicotinic acid 5-Bromo-2-methoxy-4,6-dimethylnicotinonitrile OTAVA-BB BB7110952627 SPECS AO-801/41077573 1-(3-Bromo-2-methylpyridin-4-yl)ethanone
5-Bromo-4,6-dimethyl-2-(2-pyrimidinylsulfanyl)nicotinonitrile Iflab-bb F1957-0014 Iflab-bb F1957-0019

1of4

PYRIDINE, 3-BROMO-2,4-DIMETHYL 3-Bromo-2,4-Dimethylpiperidine 3-BroMo-2,4-lutidine 3-Bromo-2,4-dimethylpyridine 27063-93-0