Benzyl (2-oxo-2-phenylethyl)carbamate
- CAS No.
- 146553-06-2
- Chemical Name:
- Benzyl (2-oxo-2-phenylethyl)carbamate
- Synonyms
- Duvelisib Impurity 1;Metaraminol Impurity 43;D-Alanine-N'-Methoxy-N'-Methylamide;Benzyl (2-oxo-2-phenylethyl)carbamate;N-Boc-D-alanine N'-Methoxy-N'-MethylaMide;(tert-butoxycarbonyl)-N-methoxy-N-methyl-D-alaninamide;(R)-tert-butyl 1-(Methoxy(Methyl)aMino)-1-oxopropan-2-ylcarbaMat;(R)-tert-butyl 1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate;tert-butyl (R)-(1-(methoxy(methyl)amino)-1-oxopropan-2-yl)carbamate;(R)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxopropan-2-yl)carbamate - [B91279]
- CBNumber:
- CB02454665
- Molecular Formula:
- C10H20N2O4
- Molecular Weight:
- 232.28
- MDL Number:
- MFCD10698131
- MOL File:
- 146553-06-2.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H320-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| HazardClass | IRRITANT |
Benzyl (2-oxo-2-phenylethyl)carbamate price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 057765 | (R)-tert-Butyl 1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate | 146553-06-2 | 5.00g | $102 | 2026-05-18 | Buy |
| Matrix Scientific | 057765 | (R)-tert-Butyl 1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate | 146553-06-2 | 25.00g | $367 | 2026-05-18 | Buy |
| Matrix Scientific | 057765 | (R)-tert-Butyl 1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate | 146553-06-2 | 100.00g | $1178 | 2026-05-18 | Buy |
| Synthonix | B91279 | (R)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxopropan-2-yl)carbamate 98% | 146553-06-2 | 1g | $98 | 2026-05-06 | Buy |
| Synthonix | B91279 | (R)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxopropan-2-yl)carbamate 98% | 146553-06-2 | 5g | $110 | 2026-05-06 | Buy |
Benzyl (2-oxo-2-phenylethyl)carbamate Chemical Properties, Uses, Production
Synthesis
15761-38-3
6638-79-5
146553-06-2
To an oven-dried 100 mL round-bottomed flask were added N-tert-butoxycarbonyl-L-alanine (3.0 g, 15.8 mmol), anhydrous CH2Cl2 (60 mL), and N,N-diisopropylethylamine (DIPEA, 2.5 mL, 14.2 mmol), and the resulting solution was cooled to 0 °C. 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC, 3.7 g, 19.0 mmol) and 1-hydroxybenzotriazole (HOBt, 2.6 g, 19.0 mmol) were added in batches over a period of 10 min at 0 °C. The mixture was stirred at 0 °C for 10 min, then N,O-dimethylhydroxylamine hydrochloride (1.9 g, 19.0 mmol) and DIPEA (3.3 mL, 19.0 mmol) were added. The mixture was continued to be stirred at 0 °C for 1 h, followed by warming up to 25 °C and kept for 16 h. The reaction was carried out at 0 °C. Upon completion of the reaction, the reaction mixture was diluted with CH2Cl2 (300 mL) and the organic layer was washed sequentially with 2N HCl (3 × 180 mL), saturated NaHCO3 solution (2 × 180 mL) and brine (2 × 180 mL). The organic phase was dried over anhydrous Na2SO4 and concentrated under reduced pressure to give a white solid amide product (3.6 g, 99% yield), which did not require further purification. Product characterization data: mp(CHCl3) 138-140 °C; 1H NMR (300 MHz, DMSO) δ 1.11 (d, J = 6.9 Hz, 3H), 1.33 (s, 9H), 3.07 (s, 3H), 3.69 (s, 3H), 4.36 (t, J = 6.9 Hz, 1H), 7.03 (d, J = 6.9 Hz, 1H); ESI MS: 4.36 (t, J = 6.9 Hz, 1H), 7.03 (d, J = 6.9 Hz, 1H). 1H); ESI MS: m/z 255 (M + Na)+. The above amide product (3.7 g, 15.8 mmol) was dissolved in anhydrous THF (100 mL) and cooled to 0°C. Lithium aluminum hydride (LiAlH4, 660 mg, 17.4 mmol) was added to this solution and the reaction was stirred for 20 min. After the completion of the reaction was monitored by TLC, the reaction was quenched with 5% HCl solution. The organic layer was evaporated and the aqueous phase was extracted with EtOAc (3 x 30 mL). The organic phases were combined, dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford tert-butyl (R)-1-(methoxy(methyl)amino)-1-oxo-2-propylcarbamate as a white solid (2.6 g, 94% yield), which did not require further purification. Product characterization data: mp(CHCl3) 82-84 °C; 1H NMR (300 MHz, DMSO) δ 1.09 (d, J = 7.5 Hz, 3H), 1.36 (s, 9H), 3.83 (t, J = 9.9 Hz, 1H), 7.33 (d, J = 5.7 Hz, 1H), 9.39 (s, 1H); ESI MS: m/z 173 (M + H)+, 196 (M + Na)+.
References
[1] Angewandte Chemie - International Edition, 2013, vol. 52, # 34, p. 8957 - 8960
[2] Angew. Chem., 2013, vol. 125, # 34, p. 9126 - 9129,4
[3] Journal of Labelled Compounds and Radiopharmaceuticals, 2014, vol. 57, # 4, p. 275 - 278
[4] Organic Letters, 2002, vol. 4, # 16, p. 2665 - 2668
[5] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 15, p. 3582 - 3586
Benzyl (2-oxo-2-phenylethyl)carbamate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Sci General Material & Chemical Ltd | 021-58388037;21-58388037 13472507714 | 35177634@qq.com;1589045147@qq.com | China | 795 | 55 |
| Wuhan TCASChem Technology Co., Ltd. | 027-86697669 13986148687 | sales@tcaschem.com | China | 3989 | 55 |
| Nanjing JinruiJiuAn Biotechnology Co., Ltd. | 025-58196018 800028039 | sales@fartop.net | China | 2227 | 55 |
| Amatek Scientific Co. Ltd. | 0512-56316828 4008675858 | sales@amateksci.com | China | 9849 | 55 |
| Shanghai Kewel Chemical Co., Ltd. | 021-64609169 18901607656 | greensnown@163.com | China | 9883 | 50 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| DebyeTec.com Inc. | 18086626237 18086626237 | 2693528373@qq.com | China | 2936 | 56 |
| Zhengzhou Alfachem Co., Ltd. | 0371-53765687 18937137882 | 3969243885@qq.com | China | 7734 | 55 |
View Latest Price from Benzyl (2-oxo-2-phenylethyl)carbamate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-06-30 | BENZYL (2-OXO-2-PHENYLETHYL)CARBAMATE
146553-06-2
|
1kg | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd |
-
- BENZYL (2-OXO-2-PHENYLETHYL)CARBAMATE
146553-06-2
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
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