5-Chloro-3-(3,5-difluorophenyl)isoxazole
- CAS No.
- 359424-44-5
- Chemical Name:
- 5-Chloro-3-(3,5-difluorophenyl)isoxazole
- Synonyms
- 5-Chloro-3-(3,5-difluorophenyl)isoxazole;Isoxazole, 5-chloro-3-(3,5-difluorophenyl)-;5-Chloro-3-(3,5-Difluorophenyl)-1,2-Oxazole
- CBNumber:
- CB02457974
- Molecular Formula:
- C9H4ClF2NO
- Molecular Weight:
- 215.58
- MDL Number:
- MFCD11217005
- MOL File:
- 359424-44-5.mol
5-Chloro-3-(3,5-difluorophenyl)isoxazole price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 126732 | 5-Chloro-3-(3,5-difluorophenyl)isoxazole | 359424-44-5 | 1.00g | $990 | 2026-05-18 | Buy |
| aablocks | AA00CLD4 | 5-Chloro-3-(3,5-difluorophenyl)isoxazole 95% | 359424-44-5 | 100mg | $19 | 2026-05-28 | Buy |
| aablocks | AA00CLD4 | 5-Chloro-3-(3,5-difluorophenyl)isoxazole 95% | 359424-44-5 | 250mg | $23 | 2026-05-28 | Buy |
| aablocks | AA00CLD4 | 5-Chloro-3-(3,5-difluorophenyl)isoxazole 95% | 359424-44-5 | 1g | $63 | 2026-05-28 | Buy |
| Crysdot | CD11136083 | 5-Chloro-3-(3,5-difluorophenyl)isoxazole 96% | 359424-44-5 | 1g | $278 | 2026-05-26 | Buy |
5-Chloro-3-(3,5-difluorophenyl)isoxazole Chemical Properties,Uses,Production
Synthesis
359424-42-3
359424-44-5
Step B. Synthesis of 3-(3,5-difluorophenyl)-5-chloroisoxazole Ethyl 3,5-difluorobenzoylacetate (1.87 g, 8.19 mmol) and hydroxylamine hydrochloride (626 mg, 9.01 mmol) were dissolved in acetic acid (24 mL) and stirred at reflux for 1 hour. Upon completion of the reaction, the crude reaction mixture was concentrated under vacuum and azeotropized with toluene twice to remove residual water. Subsequently, the crude product was suspended in phosphoryl chloride (37 mL) and triethylamine (2.37 mL, 17.1 mmol) was slowly added. The reaction mixture was stirred at reflux for 2 days, after which it was concentrated under vacuum and azeotropized with toluene three times to completely remove the phosphoryl chloride. The residue was dissolved in dichloromethane and initially purified by passing through a silica gel column (eluting with dichloromethane). After vacuum concentration, the crude product was further purified by fast chromatography (silica gel, dry on sample, eluent 5% hexane solution of ether) to give 3-(3,5-difluorophenyl)-5-chloroisoxazole (600 mg, 35% yield) as an off-white solid. 1H NMR (CDCl3, 300 MHz): δ 7.34-7.24 (m, 2H); 6.98-6.88 (m, 1H); 6.46 (s, 1H).
References
[1] Patent: US6544982, 2003, B1
[2] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 3, p. 319 - 323
5-Chloro-3-(3,5-difluorophenyl)isoxazole Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
5-Chloro-3-(3,5-difluorophenyl)isoxazole Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. | +86-28-85122536 85324413 | market@astatech.cn | China | 8016 | 55 |
| Shanghai HuanChuan Industry Co.,Ltd. | 021-61478794 | sales@hcshhai.com | China | 9781 | 50 |
| ShangHai Angti Biotechnology Co., Ltd. | 13764913901 | info@angtibio.com | China | 4975 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Hangzhou Molcore Biopharmatech Co.,Ltd | 400-711-5280 86-571-81025280 | sales@molcore.com | China | 9957 | 58 |
| Aikon International Limited | 025-58859352 13913916777 | dt3@aikonchem.com | China | 15490 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52693 | 58 |
| Shanghai Lanle Bird Industrial Co., Ltd. | 15021845385 | 765325601@qq.com | China | 3607 | 58 |
| Zhejiang Lianshuo Biotechnology Co., Ltd. | 18616526224 | lianshuo@vip.126.com | China | 9605 | 58 |
