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Elvitegravir

Elvitegravir Structure
Elvitegravir structure
CAS No.
697761-98-1
Chemical Name:
Elvitegravir
Synonyms
EVG;CS-456;CS-789;D06677;JTK 303;GS 9137;Vitekta;For Mr Wei;Elvitegravi;Elvitegravir
CBNumber:
CB02464875
Molecular Formula:
C23H23ClFNO5
Molecular Weight:
447.88
MDL Number:
MFCD11846134
MOL File:
697761-98-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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Elvitegravir Properties

Melting point 93-96°C
Boiling point 623.6±55.0 °C(Predicted)
Density 1.357±0.06 g/cm3(Predicted)
storage temp. Refrigerator
solubility DMSO (Slightly), Methanol (Slightly)
pka 0.44±0.20(Predicted)
form Solid
color Off-White to Pale Yellow
optical activity [α]/D -26 to -34°, c =0.5 in methanol
InChIKey JUZYLCPPVHEVSV-LJQANCHMSA-N
SMILES N1([C@H](CO)C(C)C)C2=C(C=C(CC3=CC=CC(Cl)=C3F)C(OC)=C2)C(=O)C(C(O)=O)=C1
CAS DataBase Reference 697761-98-1
FDA UNII 4GDQ854U53
ATC code J05AJ02
UNSPSC Code 12352200
NACRES NA.25

SAFETY

Risk and Safety Statements

Symbol(GHS)  Environment (GHS09)
GHS09
Signal word  Warning
Hazard statements  H412
Precautionary statements  P273-P501
WGK Germany  WGK 3
Storage Class 11 - Combustible Solids
Hazard Classifications Aquatic Acute 1
Aquatic Chronic 2

Elvitegravir price More Price(73)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical E1589 Elvitegravir 697761-98-1 250MG $175 2026-04-30 Buy
Cayman Chemical 17798 Elvitegravir ≥98% 697761-98-1 5mg $80 2026-04-30 Buy
Cayman Chemical 17798 Elvitegravir ≥98% 697761-98-1 10mg $149 2026-04-30 Buy
Cayman Chemical 17798 Elvitegravir ≥98% 697761-98-1 50mg $583 2026-04-30 Buy
Cayman Chemical 17798 Elvitegravir ≥98% 697761-98-1 100mg $1007 2026-04-30 Buy
Product number Packaging Price Buy
E1589 250MG $175 Buy
17798 5mg $80 Buy
17798 10mg $149 Buy
17798 50mg $583 Buy
17798 100mg $1007 Buy

Elvitegravir Chemical Properties, Uses, Production

Description

In November 2013, the European Medicines Agency (EMA) approved elvitegravir (also known as GS 9137 and JTK 303) as a single agent to be used as part of an antiviral regimen that includes a ritonavir-boosted protease inhibitor for the treatment of HIV-1 in adults without mutations indicative of elvitegravir resistance. Elvitegravir is the second of three marketed HIV integrase strand transfer inhibitors (INSTIs) including raltegravir and dolutegravir (this volume of ARMC). Elvitegravir was discovered by modification of a literature naphthyridine HIV integrase inhibitor in which the naphthyridine core served as a bioisostere for the diketo acid moiety in an original series. Serendipitously, a 4-quinolone-3-carboxylic acid precursor en route to the desired bioisosteric glyoxylic acid demonstrated modest integrase inhibition (IC50=1600 nM). Further derivatization led to elvitegravir with enhanced inhibition of integrase strand transfer (IC50=7.2 nM) and significant antiviral activity (EC50=0.9 nM). Elvitegravir was prepared in seven synthetic steps from 2,4-difluoro-5-iodobenzoic acid. The corresponding acid chloride was coupled to ethyl 3-(dimethylamino) acrylate and further substituted with S-valinol. Base promoted cyclization afforded the quinolone which was protected as silyl ether. Negishi coupling installed the 2-fluoro-3-chlorobenzyl moiety. Subsequent hydrolysis and methoxylation afforded elvitegravir.

Chemical Properties

Off-White to Pale Yellow Solid

Originator

Torii Pharmaceuticals (subsidiary of Japan Tobacco) (Japan)

Uses

Elvitegravir (EVG, JTK-303/GS-9137) is an HIV integrase inhibitor for HIV-1 IIIB, HIV-2 EHO and HIV-2 ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively.

Uses

A novel inhibitor of human immunodeficiency virus type 1 integrase.

Uses

Elvitegravir is a quinolone antibiotic that inhibits the integrase of HIV-1 (IC50 = 7.2 nM). It blocks the integration of HIV-1 cDNA through the inhibition of DNA strand transfer. Elvitegravir is used in combination with a pharmacoenhancer and nucleoside/nucleotide reverse transcriptase inhibitors to block HIV-1 replication in vivo.[Cayman Chemical]

Definition

ChEBI: A quinolinemonocarboxylic acid that is 7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid substited at position 1 by a 1-hydroxy-3-methylbutan-2-yl group and at position 6 by a 3-chloro-2-fluorobenzyl group (the S-enantiomer). It is us d in combination therapy for the treatment of HIV-1 infection.

brand name

Vitekta (Europe), Stribild (as combo in the United States and Japan)

Synthesis

Commercial 2,4-dimethoxy-5-bromo benzoic acid (61) was reacted with 0.5 equiv of butylethylmagnesium to generate the dimagnesium salt in THF, which was then lithiated at 20 to give the aryl lithium species. The aryl lithium species was then reacted with the 2-fluoro-3-chloro benzaldehyde (62) to give alcohol 63. Treatment with triethylsilane in TFA resulted in removal of the hydroxyl functionality to provide benzoic acid 64. This acid was then reacted with carbonyldiimidazole and subsequently magnesium malonate 65 to give ketoester 66 after workup. Next, condensation with DMF¨CDMA converted ketoester 66 to the vinylogous amide 67, and this material was immediately subjected to an addition¨Celimination reaction involving (S)-valinol (68) in toluene at ambient temperature to provide intermediate 69. Warming the resulting intermediate 69 in the presence of N,Obistrimethylsilyl acetamide (BSA) and potassium chloride in DMF furnished the ring-closed quinolone 70. The ester 70 was saponified with potassium hydroxide in aqueous isopropanol and then acidified and crystallized with the use of seed crystals. Upon cooling, the crystalline product elvitegravir (IX) was collected by filtration.

Synthesis_697761-98-1

target

HIV-I integrase

Elvitegravir Preparation Products And Raw materials

Raw materials

Preparation Products

Elvitegravir Suppliers

Global Suppliers ( 270)
Supplier Tel Email Country ProdList Advantage
Hangzhou Benoy Chemical Co., Ltd. 17342059697 sales@benoychem.com China 209 58
Hubei Xingcheng Biotechnology Co., Ltd 19171210221 3371991952@qq.com China 954 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9419 66
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. 17702719238 sales@sun-shinechem.com China 1204 64
LGM Pharma 1-(800)-881-8210 inquiries@lgmpharma.com United States 2110 70
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Supplier Advantage
Hangzhou Benoy Chemical Co., Ltd. 58
Hubei Xingcheng Biotechnology Co., Ltd 58
Shanghai Boyle Chemical Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
Chembest Research Laboratories Limited 61
Capot Chemical Co., Ltd 66
Jia Xing Isenchem Co.,Ltd 66
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. 64
LGM Pharma 70
Chemsky（shanghai）International Co.,Ltd. 50

Related articles

View Latest Price from Elvitegravir manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Elvitegravir pictures 2026-07-27 Elvitegravir
697761-98-1
 $47.00-155.00 99.40% 10g TargetMol Chemicals Inc.
Elvitegravir pictures 2026-05-18 Elvitegravir
697761-98-1
 1kg 98% Hefei Lbao Physical & Chemical Science Co.,Ltd
Elvitegravir pictures 2021-07-13 Elvitegravir
697761-98-1
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
  • Elvitegravir pictures
  • Elvitegravir
    697761-98-1
  • $47.00-155.00
  • 99.40%
  • TargetMol Chemicals Inc.
  • Elvitegravir pictures
  • Elvitegravir
    697761-98-1
  • $0.00
  • 98%
  • Hefei Lbao Physical & Chemical Science Co.,Ltd
  • Elvitegravir pictures
  • Elvitegravir
    697761-98-1
  • $10.00-15.00
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd

Elvitegravir Spectrum

Elvitegravir(697761-98-1)1HNMR

697761-98-1 (Elvitegravir) Related Search:

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CS-789 CS-456 GS9137;GS-9137;GS 9137 Elvitegravir,EVG,GS-9137,JTK-303 (S)-6-(3-CHLORO-2-FLUOROBENZYL)-1-(1-HYDROXY-3-METHYLBUTAN-2-YL)-7-METHOXY-4-OXO 6-[(3-chloro-2-fluorophenyl)Methyl]-1-[(2S)-1-hydroxy-2,3-diMethylbutan-2-yl]-7-Methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid GS 9137 JTK 303 6-[(3-Chloro-2-fluorophenyl)Methyl]-1,4-dihydro-1-[(1S)-1-(hydroxyMethyl)-2-Methylpropyl]-7-Methoxy-4-oxo-3-quinolinecarboxylic Acid D06677 Elvitegravir (GS-9137) Vitekta 6-(3-Chloro-2-fluorobenzyl)-1-[1(S)-(hydroxymethyl)-2-methylpropyl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid Elvitegravir (GS-9137, JTK-303) (S)-6-(3-CHLORO-2-FLUOROBENZYL)-1-(1-HYDROXY-3-METHYLBUTAN-2-YL)-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID (S)-6-(3-Chloro-2-fluorobenzyl)-1-(1-hydroxy-3-methylBUTAN-2-YL)-7-methoxy-4-oxo-1,4-dihydroqu 1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid brand name: Stribild GS-9137; GS9137; GS 9137; JTK 303; JTK-303; JTK303; EVG; ELVITEGRAVIR; BRAND NAME: STRIBILD (S)-6-(3-CHLORO-2-FLUOROBENZYL)-1-(1-HYDROXY-2,3-DIMETHYLBUTAN-2-YL)-7-METHOXY-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID Elvitegravir(GS-9137,JTK-303) Elvitegravir 6-(3-Chloro-2-fluorobenzyl)-1-[1(S)-(hydroxymethyl)-2-methylpropyl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (S)-6-(3-CHLORO-2-FLUOROBENZYL)-1-(1-HYDROXY-3-METHYLBUTAN-2-YL)-7-METHOXY-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID 3-Quinolinecarboxylic acid, 6-[(3-chloro-2-fluorophenyl)methyl]-1,4-dihydro-1-[(1S)-1-(hydroxymethyl)-2-methylpropyl]-7-methoxy-4-oxo- Elvitegravi ELVITEGRAVIR CAS 697761-98-1 (S)-6-(3-CHLORO-2-FLUOROBENZYL)-1-(1-HYDROXY-3-METHYLBUTAN-2-YL)-7-METHOXY-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID USP/EP/BP 6-[(3-chloro-2-fluorophenyl)methyl]-1-[(2S)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxoquinoline-3-carboxylic acid ElvitegravirQ: What is Elvitegravir Q: What is the CAS Number of Elvitegravir Q: What is the storage condition of Elvitegravir Q: What are the applications of Elvitegravir Elvitegravir (JTK-303) For Mr Wei Elvitegravir, quinolone HIV integrase inhibitor Elvitegravir, 10 mM in DMSO EVG 697761-98-1 595037-20-2 C23H23ClFNO5 API Inhibitor Aromatics Heterocycles Inhibitors Intermediates & Fine Chemicals Pharmaceuticals 697761-98-1